Adiponectin receptor 2: Difference between revisions
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==Structure== |
==Structure== |
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Similar to [[G protein-coupled receptor]]s (GPCRs), |
Similar to [[G protein-coupled receptor]]s (GPCRs), AdipoR2 also possesses 7 [[transmembrane domain]]s. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic [[N-terminus]], extracellular [[C-terminus]]) and does not associate with [[G protein]]s.<ref name="pmid12802337"/> |
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==Function== |
==Function== |
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The adiponectin |
The [[adiponectin receptor]]s, [[AdipoR1]] and AdipoR2, serve as receptors for globular and full-length [[adiponectin]] and mediate increased [[AMP-activated protein kinase|AMPK]] and [[Peroxisome proliferator-activated receptor alpha|PPAR-α]] ligand activities, as well as [[fatty acid]] oxidation and glucose uptake by adiponectin.<ref name="pmid12802337"/> |
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==Ligands== |
==Ligands== |
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==See also== |
==See also== |
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* [[Adiponectin receptor]] |
* [[Adiponectin receptor]] |
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* [[Adiponectin receptor 1]] |
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==References== |
==References== |
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Revision as of 12:19, 14 December 2015
Template:PBB Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene.[1]
Structure
Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.[1]
Function
The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[1]
Ligands
Agonists
Peptide
Non-peptide
Antagonists
Peptide
See also
References
- ^ a b c Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. doi:10.1038/nature01705. PMID 12802337.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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