Formate C-acetyltransferase: Difference between revisions
m Bot: Migrating 1 interwiki links, now provided by Wikidata on d:q3748139 |
|||
| Line 25: | Line 25: | ||
{{reflist|1}} |
{{reflist|1}} |
||
* {{cite journal | author = Knappe J, Blaschkowski HP, Grobner P, Schmitt T | date = 1974 | title = Pyruvate formate-lyase of Escherichia coli: the acetyl-enzyme intermediate | journal = Eur. J. Biochem. | volume = 50 | pages = 253–63 | pmid = 4615902 | doi = 10.1111/j.1432-1033.1974.tb03894.x | issue = 1 }} |
* {{cite journal | author = Knappe J, Blaschkowski HP, Grobner P, Schmitt T | date = 1974 | title = Pyruvate formate-lyase of Escherichia coli: the acetyl-enzyme intermediate | journal = Eur. J. Biochem. | volume = 50 | pages = 253–63 | pmid = 4615902 | doi = 10.1111/j.1432-1033.1974.tb03894.x | issue = 1 }} |
||
{{Acyltransferases}} |
|||
{{transferase-stub}} |
{{transferase-stub}} |
||
Revision as of 06:49, 3 January 2016
 | It has been suggested that this article be merged with Pyruvate formate lyase. (Discuss) Proposed since February 2013. |
| formate C-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.54 | ||||||||
| CAS no. | 9068-08-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a formate C-acetyltransferase (EC 2.3.1.54) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + formate CoA + pyruvate
Thus, the two substrates of this enzyme are acetyl-CoA and formate, whereas its two products are CoA and pyruvate.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:formate C-acetyltransferase. Other names in common use include pyruvate formate-lyase, pyruvic formate-lyase, and formate acetyltransferase. This enzyme participates in 3 metabolic pathways: pyruvate metabolism, propanoate metabolism, and butanoate metabolism.
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1CM5, 1H16, 1H17, 1H18, 1MZO, 1QHM, 2PFL, and 3PFL.
References
- Knappe J, Blaschkowski HP, Grobner P, Schmitt T (1974). "Pyruvate formate-lyase of Escherichia coli: the acetyl-enzyme intermediate". Eur. J. Biochem. 50 (1): 253–63. doi:10.1111/j.1432-1033.1974.tb03894.x. PMID 4615902.
{{cite journal}}: CS1 maint: multiple names: authors list (link)