Immunophilins: Difference between revisions
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Revision as of 21:12, 7 February 2016
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In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases that interconvert [sic] between the cis and trans positions.
Immunophilins are targeted by immunosuppressive drugs such as Sirolimus (earlier rapamycin), cyclosporine, and tacrolimus. For these drugs in particular, known immunophilins such as cyclophilin catalyze the cis-trans isomerization of peptide bonds, particularly X-Pro peptide bonds. This prolyl isomerase activity can be inhibited by immunosuppressive drugs.
See also
External links
- Immunophilins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- "Plant immunophilins and signal transduction" at berkeley.edu
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