TACSTD2: Difference between revisions
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'''Tumor-associated calcium signal transducer 2''' is a [[protein]] that in humans is encoded by the ''TACSTD2'' [[gene]].<ref name="pmid8382772">{{cite journal | author = Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K | title = Retroposition in a family of carcinoma-associated antigen genes | journal = Mol Cell Biol | volume = 13 | issue = 3 | pages = 1507–15 |date=Apr 1993 | pmid = 8382772 | pmc = 359462 | doi = }}</ref><ref name="pmid11306819">{{cite journal | author = Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S | title = Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 92 | issue = 1-2 | pages = 164–5 |date=Apr 2001 | pmid = 11306819 | pmc = | doi =10.1159/000056891 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4070| accessdate = }}</ref> |
'''Tumor-associated calcium signal transducer 2''' is a [[protein]] that in humans is encoded by the ''TACSTD2'' [[gene]].<ref name="pmid8382772">{{cite journal | author = Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K | title = Retroposition in a family of carcinoma-associated antigen genes | journal = Mol Cell Biol | volume = 13 | issue = 3 | pages = 1507–15 |date=Apr 1993 | pmid = 8382772 | pmc = 359462 | doi = }}</ref><ref name="pmid11306819">{{cite journal | author = Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S | title = Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 92 | issue = 1-2 | pages = 164–5 |date=Apr 2001 | pmid = 11306819 | pmc = | doi =10.1159/000056891 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4070| accessdate = }}</ref> |
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This [[intron]]less gene encodes a carcinoma-associated [[antigen]] defined by the monoclonal antibody [[GA733]]. This antigen is a member of a family including at least two type I [[membrane protein]]s. It transduces an intracellular [[calcium]] signal and acts as a [[cell surface receptor]]. Mutations of this gene result in [[gelatinous drop-like corneal dystrophy]], an [[autosomal recessive]] disorder characterized by severe corneal [[amyloidos]]is leading to [[blindness]].<ref name="entrez"/> |
This [[intron]]less gene encodes a carcinoma-associated [[antigen]] defined by the monoclonal antibody [[GA733]]. This antigen is a member of a family including at least two type I [[membrane protein]]s. It transduces an intracellular [[calcium]] signal and acts as a [[cell surface receptor]]. |
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Mutations of this gene result in [[gelatinous drop-like corneal dystrophy]], an [[autosomal recessive]] disorder characterized by severe corneal [[amyloidos]]is leading to [[blindness]].<ref name="entrez"/> |
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This antigen is the target of the [[antibody-drug conjugate]] [[Sacituzumab govitecan]]. |
This antigen is the target of the [[antibody-drug conjugate]] [[Sacituzumab govitecan]]. |
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Revision as of 00:04, 16 February 2016
Template:PBB Tumor-associated calcium signal transducer 2 is a protein that in humans is encoded by the TACSTD2 gene.[1][2][3]
This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor.
Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.[3]
This antigen is the target of the antibody-drug conjugate Sacituzumab govitecan.
References
- ^ Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K (Apr 1993). "Retroposition in a family of carcinoma-associated antigen genes". Mol Cell Biol. 13 (3): 1507–15. PMC 359462. PMID 8382772.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S (Apr 2001). "Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization". Cytogenet Cell Genet. 92 (1–2): 164–5. doi:10.1159/000056891. PMID 11306819.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b "Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2".
Further reading
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