double-solid/shaded bond of cyclohexane and cyclopentane of LSD-pip as rendered in Marvin Beans, molecular comparison of LSD with LSD-pip (both rendered with same chemistry-molecular-drawing program)
'''LSD-Pip''' is a compound from the [[ergoline]] family, related to [[LSD]] but with the ''N,N''-diethyl substitution replaced by a [[piperidine]] group. It is more potent than the corresponding pyrrolidine and morpholine analogues ([[LPD-824]] and [[LSM-775]] respectively), but is still several times less potent than LSD as a [[5-HT2A receptor|5-HT<sub>2A</sub>]] [[agonist]].<ref>[http://proquest.umi.com/pqdlink?Ver=1&Exp=01-23-2014&FMT=7&DID=1417800971&RQT=309&attempt=1&cfc=1 Michael Robert Braden PhD. Towards a biophysical understanding of hallucinogen action. Purdue University 2007.]</ref> Early studies suggested this compound to be inactive as a [[Psychedelic_drug|psychedelic]] in humans,<ref name="pmid13502837">{{cite journal |author=CERLETTI A, DOEPFNER W |title=Comparative study on the serotonin antagonism of amide derivatives of lysergic acid and of ergot alkaloids |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=122 |issue=1 |pages=124–36 |date=January 1958 |pmid=13502837 |doi= |url=}}</ref> though this does not seem to have been confirmed by any more recent work.
'''LSD-Pip''' is a compound from the [[ergoline]] family, related to [[LSD]] but with the ''N,N''-diethyl substitution replaced by a [[piperidine]] group. It is more potent than the corresponding pyrrolidine and morpholine analogues ([[LPD-824]] and [[LSM-775]] respectively), but is still several times less potent than LSD as a [[5-HT2A receptor|5-HT<sub>2A</sub>]] [[agonist]].<ref>[http://proquest.umi.com/pqdlink?Ver=1&Exp=01-23-2014&FMT=7&DID=1417800971&RQT=309&attempt=1&cfc=1 Michael Robert Braden PhD. Towards a biophysical understanding of hallucinogen action. Purdue University 2007.]</ref> Early studies suggested this compound to be inactive as a [[Psychedelic_drug|psychedelic]] in humans,<ref name="pmid13502837">{{cite journal |author=CERLETTI A, DOEPFNER W |title=Comparative study on the serotonin antagonism of amide derivatives of lysergic acid and of ergot alkaloids |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=122 |issue=1 |pages=124–36 |date=January 1958 |pmid=13502837 |doi= |url=}}</ref> though this does not seem to have been confirmed by any more recent work.
LSD-Pip is a compound from the ergoline family, related to LSD but with the N,N-diethyl substitution replaced by a piperidine group. It is more potent than the corresponding pyrrolidine and morpholine analogues (LPD-824 and LSM-775 respectively), but is still several times less potent than LSD as a 5-HT2Aagonist.[1] Early studies suggested this compound to be inactive as a psychedelic in humans,[2] though this does not seem to have been confirmed by any more recent work.
^CERLETTI A, DOEPFNER W (January 1958). "Comparative study on the serotonin antagonism of amide derivatives of lysergic acid and of ergot alkaloids". The Journal of Pharmacology and Experimental Therapeutics. 122 (1): 124–36. PMID13502837.
