Phosphatidylinositol-4,5-bisphosphate 4-phosphatase: Difference between revisions

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Phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Identifiers
EC no.	3.1.3.78
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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PubMed	articles
NCBI	proteins

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Revision as of 18:09, 30 March 2016

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, type I PtdIns-4,5-P2 4-Ptase, type II PtdIns-4,5-P2 4-Ptase, IpgD, PtdIns-4,5-P2 4-phosphatase type I, PtdIns-4,5-P2 4-phosphatase type II, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, type 1 4-phosphatase) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O

\rightleftharpoons

1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate

This enzyme participates in one of the mammalian pathways for degradation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2].

References

^ Niebuhr, K., Giuriato, S., Pedron, T., Philpott, D.J., Gaits, F., Sable, J., Sheetz, M.P., Parsot, C., Sansonetti, P.J. and Payrastre, B. (2002). "Conversion of PtdIns(4,5)P₂ into PtdIns(5)P by the S. flexneri effector IpgD reorganizes host cell morphology". EMBO J. 21 (19): 5069–5078. doi:10.1093/emboj/cdf522. PMC 129044. PMID 12356723.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Ungewickell, A., Hugge, C., Kisseleva, M., Chang, S.C., Zou, J., Feng, Y., Galyov, E.E., Wilson, M. and Majerus, P.W. (2005). "The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases". Proc. Natl. Acad. Sci. USA. 102 (52): 18854–18859. doi:10.1073/pnas.0509740102. PMID 16365287.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Zou, J., Marjanovic, J., Kisseleva, M.V., Wilson, M. and Majerus, P.W. (2007). "Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis". Proc. Natl. Acad. Sci. USA. 104 (43): 16834–16839. doi:10.1073/pnas.0708189104. PMID 17940011.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Mason, D., Mallo, G.V., Terebiznik, M.R., Payrastre, B., Finlay, B.B., Brumell, J.H., Rameh, L. and Grinstein, S. (2007). "Alteration of epithelial structure and function associated with PtdIns(4,5)P₂ degradation by a bacterial phosphatase". J. Gen. Physiol. 129 (4): 267–283. doi:10.1085/jgp.200609656. PMID 17389247.{{cite journal}}: CS1 maint: multiple names: authors list (link)

External links

Phosphatidylinositol-4,5-bisphosphate+4-phosphatase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[1] Niebuhr, K., Giuriato, S., Pedron, T., Philpott, D.J., Gaits, F., Sable, J., Sheetz, M.P., Parsot, C., Sansonetti, P.J. and Payrastre, B. (2002). "Conversion of PtdIns(4,5)P₂ into PtdIns(5)P by the S. flexneri effector IpgD reorganizes host cell morphology". EMBO J. 21 (19): 5069–5078. doi:10.1093/emboj/cdf522. PMC 129044. PMID 12356723.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[2] Ungewickell, A., Hugge, C., Kisseleva, M., Chang, S.C., Zou, J., Feng, Y., Galyov, E.E., Wilson, M. and Majerus, P.W. (2005). "The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases". Proc. Natl. Acad. Sci. USA. 102 (52): 18854–18859. doi:10.1073/pnas.0509740102. PMID 16365287.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[3] Zou, J., Marjanovic, J., Kisseleva, M.V., Wilson, M. and Majerus, P.W. (2007). "Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis". Proc. Natl. Acad. Sci. USA. 104 (43): 16834–16839. doi:10.1073/pnas.0708189104. PMID 17940011.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[4] Mason, D., Mallo, G.V., Terebiznik, M.R., Payrastre, B., Finlay, B.B., Brumell, J.H., Rameh, L. and Grinstein, S. (2007). "Alteration of epithelial structure and function associated with PtdIns(4,5)P₂ degradation by a bacterial phosphatase". J. Gen. Physiol. 129 (4): 267–283. doi:10.1085/jgp.200609656. PMID 17389247.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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 }}
-'''Phosphatidylinositol-4,5-bisphosphate 4-phosphatase''' ({{EC number|3.1.3.78}}, ''phosphatidylinositol-4,5-bisphosphate 4-phosphatase I'', ''phosphatidylinositol-4,5-bisphosphate 4-phosphatase II'', ''type I PtdIns-4,5-P2 4-Ptase'', ''type II PtdIns-4,5-P2 4-Ptase'', ''IpgD'', ''PtdIns-4,5-P2 4-phosphatase type I'', ''PtdIns-4,5-P2 4-phosphatase type II'', ''type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase'', ''type 1 4-phosphatase'') is an [[enzyme]] with system name ''1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase''.<ref>{{cite journal | title = Conversion of PtdIns(4,5)''P''<sub>2</sub> into PtdIns(5)P by the ''S. flexneri'' effector IpgD reorganizes host cell morphology |author = Niebuhr, K., Giuriato, S., Pedron, T., Philpott, D.J., Gaits, F., Sable, J., Sheetz, M.P., Parsot, C., Sansonetti, P.J. and Payrastre, B. |journal = EMBO J. |year = 2002 |volume = 21 |pages = 5069–5078 |pmid = 12356723 |issue=19 |pmc=129044 |doi=10.1093/emboj/cdf522}}</ref><ref>{{cite journal | title = The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases |author = Ungewickell, A., Hugge, C., Kisseleva, M., Chang, S.C., Zou, J., Feng, Y., Galyov, E.E., Wilson, M. and Majerus, P.W. |journal = Proc. Natl. Acad. Sci. USA |year = 2005 |volume = 102 |pages = 18854–18859 |pmid = 16365287 |doi=10.1073/pnas.0509740102 |issue=52}}</ref><ref>{{cite journal | title = Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis |author = Zou, J., Marjanovic, J., Kisseleva, M.V., Wilson, M. and Majerus, P.W. |journal = Proc. Natl. Acad. Sci. USA |year = 2007 |volume = 104 |pages = 16834–16839 |pmid = 17940011 |doi=10.1073/pnas.0708189104 |issue=43}}</ref><ref>{{cite journal | title = Alteration of epithelial structure and function associated with PtdIns(4,5)''P''<sub>2</sub> degradation by a bacterial phosphatase |author = Mason, D., Mallo, G.V., Terebiznik, M.R., Payrastre, B., Finlay, B.B., Brumell, J.H., Rameh, L. and Grinstein, S. |journal = J. Gen. Physiol. |year = 2007 |volume = 129 |pages = 267–283 |pmid = 17389247 |doi=10.1085/jgp.200609656 |issue=4}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
+'''Phosphatidylinositol-4,5-bisphosphate 4-phosphatase''' ({{EC number|3.1.3.78}}, ''phosphatidylinositol-4,5-bisphosphate 4-phosphatase I'', ''phosphatidylinositol-4,5-bisphosphate 4-phosphatase II'', ''type I PtdIns-4,5-P2 4-Ptase'', ''type II PtdIns-4,5-P2 4-Ptase'', ''IpgD'', ''PtdIns-4,5-P2 4-phosphatase type I'', ''PtdIns-4,5-P2 4-phosphatase type II'', ''type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase'', ''type 1 4-phosphatase'') is an [[enzyme]] with systematic name ''1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase''.<ref>{{cite journal | title = Conversion of PtdIns(4,5)''P''<sub>2</sub> into PtdIns(5)P by the ''S. flexneri'' effector IpgD reorganizes host cell morphology |author = Niebuhr, K., Giuriato, S., Pedron, T., Philpott, D.J., Gaits, F., Sable, J., Sheetz, M.P., Parsot, C., Sansonetti, P.J. and Payrastre, B. |journal = EMBO J. |year = 2002 |volume = 21 |pages = 5069–5078 |pmid = 12356723 |issue=19 |pmc=129044 |doi=10.1093/emboj/cdf522}}</ref><ref>{{cite journal | title = The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases |author = Ungewickell, A., Hugge, C., Kisseleva, M., Chang, S.C., Zou, J., Feng, Y., Galyov, E.E., Wilson, M. and Majerus, P.W. |journal = Proc. Natl. Acad. Sci. USA |year = 2005 |volume = 102 |pages = 18854–18859 |pmid = 16365287 |doi=10.1073/pnas.0509740102 |issue=52}}</ref><ref>{{cite journal | title = Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis |author = Zou, J., Marjanovic, J., Kisseleva, M.V., Wilson, M. and Majerus, P.W. |journal = Proc. Natl. Acad. Sci. USA |year = 2007 |volume = 104 |pages = 16834–16839 |pmid = 17940011 |doi=10.1073/pnas.0708189104 |issue=43}}</ref><ref>{{cite journal | title = Alteration of epithelial structure and function associated with PtdIns(4,5)''P''<sub>2</sub> degradation by a bacterial phosphatase |author = Mason, D., Mallo, G.V., Terebiznik, M.R., Payrastre, B., Finlay, B.B., Brumell, J.H., Rameh, L. and Grinstein, S. |journal = J. Gen. Physiol. |year = 2007 |volume = 129 |pages = 267–283 |pmid = 17389247 |doi=10.1085/jgp.200609656 |issue=4}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
 : 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> 1-phosphatidyl-1D-myo-inositol 5-phosphate + [[phosphate]]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)