Interleukin 31: Difference between revisions
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{{PBB|geneid=386653}} |
{{PBB|geneid=386653}} |
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'''Interleukin-31''' |
'''Interleukin-31''' ('''IL-31''') is a [[protein]] that in humans is encoded by the ''IL31'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: interleukin 31| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=386653| accessdate = }}</ref><ref name="pmid15184896"/> |
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== Function == |
== Function == |
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Revision as of 20:36, 4 April 2016
Interleukin-31 (IL-31) is a protein that in humans is encoded by the IL31 gene.[1][2]
Function
IL-31 is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). The structure of IL-31 places it in the IL-6 family of cytokines. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells.[1]
Clinical significance
IL-31 is believed to play a role in inflammation of the skin.[2]
References
- ^ a b "Entrez Gene: interleukin 31".
- ^ a b Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA (July 2004). "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice". Nat. Immunol. 5 (7): 752–60. doi:10.1038/ni1084. PMID 15184896.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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