Drug overdose

A drug overdose occurs when a chemical substance (i.e. drug) is ingested in quantities and/or concentrations large enough to overwhelm the homeostasis of a living organism, causing severe illness or death. Essentially it is a type of poisoning.

Types

The word "overdose" implies that there is a safe dosage and therefore the term overdose is commonly only applied to drugs, not poisons.

Drug overdoses are sometimes caused intentionally to commit suicide, but many drug overdoses are accidental and are usually the result of either irresponsible behavior (such as overindulging at a party), or the misreading of product labels. Other causes of overdose (especially heroin) include multiple drug use with counterindications (cocaine/amphetamines/alcohol) or use after a period of abstinence.

A common unintentional overdose in young children involves multi-vitamins containing iron. Iron is a component of the hemoglobin molecule in blood, used to transport oxygen to living cells. When taken in small amounts, iron allows the body to replenish hemoglobin, but in large amounts it causes severe pH imbalances in the body. If this overdose is not treated with chelation therapy, it can lead to death.

Symptoms

Symptoms of overdose occur in various forms:

• Exaggerated form of normal action (sleepiness on antiepileptics, hypoglycemia on insulin)
• Other effects due to chemical properties of the medication (metabolic acidosis in aspirin, liver failure due to paracetamol)
• Non-specific symptoms due to central nervous system irritation (confusion, vertigo, nausea, vomiting)

Diagnosis and management

Diagnosis and management are generally straightforward if the drug is known. The diagnosis can be very difficult if the patient cannot (or refuses to) state which medication has been overdosed. At times, certain symptoms and signs exhibited by the patient, or blood tests, can reveal the drug in question. Even without knowing the drug, most patients can be treated with general supportive measures.

In some instances, empirical antidotes may be administered if there is sufficient indication that the patient has overdosed on a particular type of medication: naloxone in opioids and flumazenil in benzodiazepines. Rapid reversal of symptoms may serve as proof in these cases.

First aid

Wikipedia:Medical disclaimer

First aid can prevent a death from overdose on depressants as it may take several hours for someone to die in these cases. The common drugs in this category include opiates ( ie. heroin, morphine and methadone), alcohol, and certain prescription drugs such as benzodiazepines. Signs of overdose are those of a depressed central nervous system — slow, infrequent or shallow breathing, blue lips or fingernails, cold or pale skin, slow or faint pulse, snoring or gurgling noises, and the inability to be woken from nodding off.

The first step is to stay calm and see if you can get a response from the person by pinching an earlobe, calling their name or rubbing your knuckles against their chest. If there is no response, see if they are breathing and make sure nothing is blocking their airway, such as vomit or their tongue. Roll them on to their side into the recovery position. Ring for an ambulance.

People can overdose on stimulants, such as amphetamines, ecstasy and cocaine, with symptoms such as rapid heartbeat, muscle cramps, seizures, paranoia, psychosis, confusion, loss of control of movement, vomiting and unconsciousness. First aid in these cases involves staying with the person and helping them to remain calm. Move them to a quiet area, and where possible, apply a wet cloth to their neck or forehead. If unconscious, place them in the recovery position. Call an ambulance.

Key points to prevent overdose on illicit drugs

• Be informed about any drugs you are taking.
• Do not take different types of illicit drugs together. [1]
• When you are unsure of a drug's strength, try a small dose first.
• Be aware of low tolerance following a period of abstinence (e.g. a period in detox or rehab or after leaving prison) when it comes to illicit drugs.

Common causes

Common types of drugs that are overdosed on:

• Barbiturates
  • Seconal
  • Nembutal
• Narcotics
  • Heroin
• Stimulants
  • Cocaine
• Ethyl Alcohol
  • Alcoholic beverages
• Prescription drugs
  • drug "cocktails", or a combination of numerous drugs.

See also

• List of deaths by accidental drug overdose

External links

• Fact sheets on illicit drugs, overdose prevention, detox and harm reduction strategies
• Drug-specific information about overdosing