Pyroglutamyl-peptidase II: Difference between revisions

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Pyroglutamyl-peptidase II
Pyroglutamyl-peptidase II
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EC no.	3.4.19.6
CAS no.	60063-88-9
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MetaCyc	metabolic pathway
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Revision as of 06:39, 24 May 2016

Pyroglutamyl-peptidase II (EC 3.4.19.6, thyroliberinase, pyroglutamyl aminopeptidase II, thyrotropin-releasing factor pyroglutamate aminopeptidase, pyroglutamate aminopeptidase II, pyroglutamyl peptidase II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading peptidase, TRH aminopeptidase) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Release of the N-terminal pyroglutamyl group from pGlu--His-Xaa tripeptides and pGlu--His-Xaa-Gly tetrapeptides

This enzyme is highly specific for thyrotropin releasing hormone.

References

^ Bauer, K.; Nowak, P. (1979). "Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond". Eur. J. Biochem. 99: 239–246. doi:10.1111/j.1432-1033.1979.tb13250.x. PMID 115687.
^ O'Connor, B.; O'Cuinn, G. (1985). "Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain". Eur. J. Biochem. 150: 47–52. doi:10.1111/j.1432-1033.1985.tb08986.x. PMID 2862039.
^ Wilk, S.; Wilk, E.K. (1989). "Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme". Neurochem. Int. 15: 81–89. doi:10.1016/0197-0186(89)90079-x.

External links

Pyroglutamyl-peptidase+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[1] Bauer, K.; Nowak, P. (1979). "Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond". Eur. J. Biochem. 99: 239–246. doi:10.1111/j.1432-1033.1979.tb13250.x. PMID 115687.

[2] O'Connor, B.; O'Cuinn, G. (1985). "Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain". Eur. J. Biochem. 150: 47–52. doi:10.1111/j.1432-1033.1985.tb08986.x. PMID 2862039.

[3] Wilk, S.; Wilk, E.K. (1989). "Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme". Neurochem. Int. 15: 81–89. doi:10.1016/0197-0186(89)90079-x.

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-'''Pyroglutamyl-peptidase II''' ({{EC number|3.4.19.6}}, ''thyroliberinase'', ''pyroglutamyl aminopeptidase II'', ''thyrotropin-releasing factor pyroglutamate aminopeptidase'', ''pyroglutamate aminopeptidase II'', ''pyroglutamyl peptidase II'', ''thyroliberin-hydrolyzing pyroglutamate aminopeptidase'', ''thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase'', ''thyrotropin-releasing hormone-degrading peptidase'', ''TRH aminopeptidase'') is an [[enzyme]].<ref>{{cite journal | title = Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond |author = Bauer, K. and Nowak, P. |journal = Eur. J. Biochem. |date = 1979 |volume = 99 |pages = 239–246 |pmid = 115687 |doi=10.1111/j.1432-1033.1979.tb13250.x}}</ref><ref>{{cite journal | title = Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain |author = O'Connor, B. and O'Cuinn, G. |journal = Eur. J. Biochem. |date = 1985 |volume = 150 |pages = 47–52 |pmid = 2862039 |doi=10.1111/j.1432-1033.1985.tb08986.x}}</ref><ref>{{cite journal | title = Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme |author = Wilk, S. and Wilk, E.K. |journal = Neurochem. Int. |date = 1989 |volume = 15 |pages = 81–89 |pmid = |doi=10.1016/0197-0186(89)90079-x}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
+'''Pyroglutamyl-peptidase II''' ({{EC number|3.4.19.6}}, ''thyroliberinase'', ''pyroglutamyl aminopeptidase II'', ''thyrotropin-releasing factor pyroglutamate aminopeptidase'', ''pyroglutamate aminopeptidase II'', ''pyroglutamyl peptidase II'', ''thyroliberin-hydrolyzing pyroglutamate aminopeptidase'', ''thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase'', ''thyrotropin-releasing hormone-degrading peptidase'', ''TRH aminopeptidase'') is an [[enzyme]].<ref>{{cite journal | title = Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond |author1=Bauer, K.  |author2=Nowak, P. |journal = Eur. J. Biochem. |date = 1979 |volume = 99 |pages = 239–246 |pmid = 115687 |doi=10.1111/j.1432-1033.1979.tb13250.x}}</ref><ref>{{cite journal | title = Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain |author1=O'Connor, B.  |author2=O'Cuinn, G. |journal = Eur. J. Biochem. |date = 1985 |volume = 150 |pages = 47–52 |pmid = 2862039 |doi=10.1111/j.1432-1033.1985.tb08986.x}}</ref><ref>{{cite journal | title = Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme |author1=Wilk, S.  |author2=Wilk, E.K. |journal = Neurochem. Int. |date = 1989 |volume = 15 |pages = 81–89 |pmid = |doi=10.1016/0197-0186(89)90079-x}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
 : Release of the [[N-terminal]] pyroglutamyl group from pGlu--His-Xaa [[tripeptide]]s and pGlu--His-Xaa-Gly [[tetrapeptide]]s

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)