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{{correct title|reason=namespace|title=N:C ratio}}
{{correct title|reason=namespace|title=N:C ratio}}
The '''nuclear-cytoplasmic ratio''' (also variously known as the '''nucleus:cytoplasm ratio''', '''nucleus-cytoplasm ratio''', '''N:C ratio''', or '''N/C''') is a measurement used in [[cell biology]]. It is a ratio of the size (i.e., volume) of the [[cell nucleus|nucleus]] of a cell to the size of the [[cytoplasm]] of that cell.<ref name="Turgeon">{{cite book | author = Turgeon, Mary Louise | authorlink = | editor = | others = | title = Clinical hematology: theory and procedures | edition = | language = | publisher = Lippincott Williams & Wilkins | location = Hagerstwon, MD | year = 2005 | origyear = | pages = 67 | quote = | isbn = 0-7817-5007-5 }}</ref>
The '''nuclear-cytoplasmic ratio''' (also variously known as the '''nucleus:cytoplasm ratio''', '''nucleus-cytoplasm ratio''', '''N:C ratio''', or '''N/C''') is a measurement used in [[cell biology]]. It is a ratio of the size (i.e., volume) of the [[cell nucleus|nucleus]] of a cell to the size of the [[cytoplasm]] of that cell.<ref name="Turgeon">{{cite book | author = Turgeon, Mary Louise | title = Clinical hematology: theory and procedures | edition = | language = | publisher = Lippincott Williams & Wilkins | location = Hagerstwon, MD | year = 2005 | origyear = | pages = 67 | quote = | isbn = 0-7817-5007-5 }}</ref>


The N:C ratio indicates the maturity of a cell, because as a cell matures the size of its nucleus generally decreases. So, for example, "blast" forms of [[erythrocyte]]s, [[leukocyte]]s, and [[megakaryocyte]]s start with an N:C ratio of 4:1, which decreases as they mature to 2:1 or even 1:1 (with exceptions for mature [[thrombocyte]]s and erythrocytes, which are [[anuclear cell]]s, and mature [[lymphocyte]]s, which only decrease to a 3:1 ratio and often retain the original 4:1 ratio).<ref name="Turgeon"/>
The N:C ratio indicates the maturity of a cell, because as a cell matures the size of its nucleus generally decreases. So, for example, "blast" forms of [[erythrocyte]]s, [[leukocyte]]s, and [[megakaryocyte]]s start with an N:C ratio of 4:1, which decreases as they mature to 2:1 or even 1:1 (with exceptions for mature [[thrombocyte]]s and erythrocytes, which are [[anuclear cell]]s, and mature [[lymphocyte]]s, which only decrease to a 3:1 ratio and often retain the original 4:1 ratio).<ref name="Turgeon"/>
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{{refbegin}}
* {{cite book|title=Diagnostic cell pathology in tissue and smears|author=Herbert E. Nieburgs|location=New York &amp; London|publisher=Grune &amp; Stratton|date=1967|chapter=Nuclear/Cytoplasmic Ratio (N/C) and Nuclear Chromatin|pages=15&ndash;16}}
* {{cite book|title=Diagnostic cell pathology in tissue and smears|author=Herbert E. Nieburgs|location=New York &amp; London|publisher=Grune &amp; Stratton|date=1967|chapter=Nuclear/Cytoplasmic Ratio (N/C) and Nuclear Chromatin|pages=15&ndash;16}}
* {{cite book | author = Takahashi, Masayoshi | authorlink = | editor = | others = | title = Color atlas of cancer cytology | edition = 2nd | language = | publisher = Igaku-Shoin | location = New York | year = 1981 | origyear = | pages = 32–34, 50 | quote = | isbn = 0-89640-050-6 }}
* {{cite book | author = Takahashi, Masayoshi | title = Color atlas of cancer cytology | edition = 2nd | language = | publisher = Igaku-Shoin | location = New York | year = 1981 | origyear = | pages = 32–34, 50 | quote = | isbn = 0-89640-050-6 }}
* {{cite book|title=Theory and practice of histological techniques|author=John D. Bancroft and Alan Stevens|edition=2nd|publisher=Churchill Livingstone|date=1982|pages=438–439}}
* {{cite book|title=Theory and practice of histological techniques|author1=John D. Bancroft |author2=Alan Stevens |edition=2nd|publisher=Churchill Livingstone|date=1982|pages=438–439}}
{{refend}}
{{refend}}


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Revision as of 19:39, 27 May 2016

The correct title of this article is N:C ratio. The substitution or omission of the colon is due to technical restrictions.

The nuclear-cytoplasmic ratio (also variously known as the nucleus:cytoplasm ratio, nucleus-cytoplasm ratio, N:C ratio, or N/C) is a measurement used in cell biology. It is a ratio of the size (i.e., volume) of the nucleus of a cell to the size of the cytoplasm of that cell.[1]

The N:C ratio indicates the maturity of a cell, because as a cell matures the size of its nucleus generally decreases. So, for example, "blast" forms of erythrocytes, leukocytes, and megakaryocytes start with an N:C ratio of 4:1, which decreases as they mature to 2:1 or even 1:1 (with exceptions for mature thrombocytes and erythrocytes, which are anuclear cells, and mature lymphocytes, which only decrease to a 3:1 ratio and often retain the original 4:1 ratio).[1]

An increased N:C ratio is commonly associated with precancerous dysplasia as well as with malignant cells.

See also

References

  1. ^ a b Turgeon, Mary Louise (2005). Clinical hematology: theory and procedures. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 67. ISBN 0-7817-5007-5.

Further reading

  • Herbert E. Nieburgs (1967). "Nuclear/Cytoplasmic Ratio (N/C) and Nuclear Chromatin". Diagnostic cell pathology in tissue and smears. New York & London: Grune & Stratton. pp. 15–16.
  • Takahashi, Masayoshi (1981). Color atlas of cancer cytology (2nd ed.). New York: Igaku-Shoin. pp. 32–34, 50. ISBN 0-89640-050-6.
  • John D. Bancroft; Alan Stevens (1982). Theory and practice of histological techniques (2nd ed.). Churchill Livingstone. pp. 438–439.


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