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{{Infobox_gene}}
{{Infobox_gene}}
'''Serine protease HTRA1''' is an [[enzyme]] that in humans is encoded by the ''HTRA1'' [[gene]].<ref name="pmid8977104">{{cite journal | author = Zumbrunn J, Trueb B | title = Primary structure of a putative serine protease specific for IGF-binding proteins | journal = FEBS Lett | volume = 398 | issue = 2–3 | pages = 187–92 |date=Jan 1997 | pmid = 8977104 | pmc = | doi =10.1016/S0014-5793(96)01229-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HTRA1 HtrA serine peptidase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5654| accessdate = }}</ref> The HTRA1 protein is composed of four distinct [[protein domain]]s. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a [[kazal domain]], a [[trypsin]]-like peptidase domain and a [[PDZ domain]].
'''Serine protease HTRA1''' is an [[enzyme]] that in humans is encoded by the ''HTRA1'' [[gene]].<ref name="pmid8977104">{{cite journal |vauthors=Zumbrunn J, Trueb B | title = Primary structure of a putative serine protease specific for IGF-binding proteins | journal = FEBS Lett | volume = 398 | issue = 2–3 | pages = 187–92 |date=Jan 1997 | pmid = 8977104 | pmc = | doi =10.1016/S0014-5793(96)01229-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HTRA1 HtrA serine peptidase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5654| accessdate = }}</ref> The HTRA1 protein is composed of four distinct [[protein domain]]s. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a [[kazal domain]], a [[trypsin]]-like peptidase domain and a [[PDZ domain]].


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| citations =
| citations =
*{{Cite journal |doi=10.1038/eye.2011.37 |title=Complement in age-related macular degeneration: a focus on function |year=2011 |last1=Bradley |first1=D T |last2=Zipfel |first2=P F |last3=Hughes |first3=A E |journal=Eye |volume=25 |issue=6 |pmid=21394116 |pmc=3178140}}
*{{Cite journal |doi=10.1038/eye.2011.37 |title=Complement in age-related macular degeneration: a focus on function |year=2011 |last1=Bradley |first1=D T |last2=Zipfel |first2=P F |last3=Hughes |first3=A E |journal=Eye |volume=25 |issue=6 |pmid=21394116 |pmc=3178140}}
*{{cite journal | author=Zurawa-Janicka D, Narkiewicz J, Lipińska B |title=[Characterization of the HtrA family of proteins] |journal=Postepy Biochem. |volume=53 |issue= 1 |pages= 27–36 |year= 2007 |pmid= 17718385 |doi= }}
*{{cite journal |vauthors=Zurawa-Janicka D, Narkiewicz J, Lipińska B |title=[Characterization of the HtrA family of proteins] |journal=Postepy Biochem. |volume=53 |issue= 1 |pages= 27–36 |year= 2007 |pmid= 17718385 |doi= }}
*{{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal | author=Zumbrunn J, Trueb B |title=Localization of the gene for a serine protease with IGF-binding domain (PRSS11) to human chromosome 10q25.3-q26.2 |journal=Genomics |volume=45 |issue= 2 |pages= 461–2 |year= 1998 |pmid= 9344681 |doi= 10.1006/geno.1997.4953 }}
*{{cite journal |vauthors=Zumbrunn J, Trueb B |title=Localization of the gene for a serine protease with IGF-binding domain (PRSS11) to human chromosome 10q25.3-q26.2 |journal=Genomics |volume=45 |issue= 2 |pages= 461–2 |year= 1998 |pmid= 9344681 |doi= 10.1006/geno.1997.4953 }}
*{{cite journal |vauthors=Hu SI, Carozza M, Klein M, etal |title=Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34406–12 |year= 1999 |pmid= 9852107 |doi=10.1074/jbc.273.51.34406 }}
*{{cite journal |vauthors=Hu SI, Carozza M, Klein M, etal |title=Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34406–12 |year= 1999 |pmid= 9852107 |doi=10.1074/jbc.273.51.34406 }}
*{{cite journal |vauthors=Baldi A, De Luca A, Morini M, etal |title=The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells |journal=Oncogene |volume=21 |issue= 43 |pages= 6684–8 |year= 2002 |pmid= 12242667 |doi= 10.1038/sj.onc.1205911 }}
*{{cite journal |vauthors=Baldi A, De Luca A, Morini M, etal |title=The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells |journal=Oncogene |volume=21 |issue= 43 |pages= 6684–8 |year= 2002 |pmid= 12242667 |doi= 10.1038/sj.onc.1205911 }}

Revision as of 08:27, 31 May 2016

HTRA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHTRA1, ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11, CADASIL2, HtrA serine peptidase 1
External IDsOMIM: 602194; MGI: 1929076; HomoloGene: 31114; GeneCards: HTRA1; OMA:HTRA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5654

56213

Ensembl

ENSG00000166033

ENSMUSG00000006205

UniProt

Q92743

Q9R118

RefSeq (mRNA)

NM_002775

NM_019564

RefSeq (protein)

NP_002766

NP_062510

Location (UCSC)Chr 10: 122.46 – 122.51 MbChr 7: 130.54 – 130.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene.[5][6] The HTRA1 protein is composed of four distinct protein domains. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a kazal domain, a trypsin-like peptidase domain and a PDZ domain.

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References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166033 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006205 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zumbrunn J, Trueb B (Jan 1997). "Primary structure of a putative serine protease specific for IGF-binding proteins". FEBS Lett. 398 (2–3): 187–92. doi:10.1016/S0014-5793(96)01229-X. PMID 8977104.
  6. ^ "Entrez Gene: HTRA1 HtrA serine peptidase 1".

Further reading

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