RAPGEF5: Difference between revisions

RAPGEF5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGY
Identifiers
Aliases	RAPGEF5, GFR, MR-GEF, REPAC, Rap guanine nucleotide exchange factor 5, MRGEF
External IDs	OMIM: 609527; MGI: 2444365; HomoloGene: 56563; GeneCards: RAPGEF5; OMA:RAPGEF5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	22,357,154 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	117,723,472 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; Pons; ; inferior olivary nucleus; ; corpus callosum; ; superior vestibular nucleus; ; pars reticulata; ; subthalamic nucleus; ; postcentral gyrus; ; external globus pallidus; ; dorsal motor nucleus of vagus nerve;
	Top expressed in
	superior cervical ganglion; ; otolith organ; ; utricle; ; anterior amygdaloid area; ; right lung; ; lateral septal nucleus; ; zygote; ; left lung lobe; ; oocyte; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTP-dependent protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	nucleus; nucleoplasm; nuclear body;
Biological process	small GTPase mediated signal transduction; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	9771
	217944
	ENSG00000136237
	ENSMUSG00000041992
	Q92565
	Q8C0Q9
	NM_012294; NM_001367600; NM_001367601; NM_001367602; NM_001367603
	NM_175930; NM_001373989
	NP_036426; NP_001354529; NP_001354530; NP_001354531; NP_001354532
	NP_787126; NP_001360918
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 19:03, 3 June 2016

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136237 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041992 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
^ Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y (Oct 1999). "Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1". FEBS Lett. 457 (1): 85–9. doi:10.1016/S0014-5793(99)01012-1. PMID 10486569.
^ "Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5".

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 {{Infobox_gene}}
-'''Rap guanine nucleotide exchange factor 5''' is a [[protein]] that in humans is encoded by the ''RAPGEF5'' [[gene]].<ref name="pmid9039502">{{cite journal | author = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Res | volume = 3 | issue = 5 | pages = 321–9, 341–54 |date=May 1997 | pmid = 9039502 | pmc =  | doi =10.1093/dnares/3.5.321  }}</ref><ref name="pmid10486569">{{cite journal | author = Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y | title = Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1 | journal = FEBS Lett | volume = 457 | issue = 1 | pages = 85–9 |date=Oct 1999 | pmid = 10486569 | pmc =  | doi =10.1016/S0014-5793(99)01012-1  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9771| accessdate = }}</ref>
+'''Rap guanine nucleotide exchange factor 5''' is a [[protein]] that in humans is encoded by the ''RAPGEF5'' [[gene]].<ref name="pmid9039502">{{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Res | volume = 3 | issue = 5 | pages = 321–9, 341–54 |date=May 1997 | pmid = 9039502 | pmc =  | doi =10.1093/dnares/3.5.321  }}</ref><ref name="pmid10486569">{{cite journal | vauthors = Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y | title = Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1 | journal = FEBS Lett | volume = 457 | issue = 1 | pages = 85–9 |date=Oct 1999 | pmid = 10486569 | pmc =  | doi =10.1016/S0014-5793(99)01012-1  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9771| accessdate = }}</ref>
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 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
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 | citations =
 *{{cite journal   |vauthors=de Rooij J, Rehmann H, van Triest M, etal |title=Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20829–36 |year= 2000 |pmid= 10777494 |doi= 10.1074/jbc.M001113200 }}
-*{{cite journal  | author=Rebhun JF, Castro AF, Quilliam LA |title=Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34901–8 |year= 2001 |pmid= 10934204 |doi= 10.1074/jbc.M005327200 }}
+*{{cite journal  | vauthors=Rebhun JF, Castro AF, Quilliam LA |title=Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34901–8 |year= 2001 |pmid= 10934204 |doi= 10.1074/jbc.M005327200 }}
 *{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
 *{{cite journal   |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423  | pmc=2882961 }}
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