Tissue inhibitor of metalloproteinase: Difference between revisions
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The [[matrix metalloproteinase]]s are inhibited by specific endogenous '''tissue inhibitors of metalloproteinases''' (TIMPs), which comprise a family of four protease inhibitors: ''[[TIMP1]]'', ''[[TIMP2]]'', ''[[TIMP3]]'' and ''[[TIMP4]]''.<ref>{{Cite journal| |
The [[matrix metalloproteinase]]s are inhibited by specific endogenous '''tissue inhibitors of metalloproteinases''' (TIMPs), which comprise a family of four protease inhibitors: ''[[TIMP1]]'', ''[[TIMP2]]'', ''[[TIMP3]]'' and ''[[TIMP4]]''.<ref>{{Cite journal|vauthors=Brew K, Dinakarpandian D, Nagase H |title=Tissue inhibitors of metalloproteinases: evolution, structure and function |journal=Biochim Biophys Acta |volume=1477 |issue=1–2 |pages=267–83 |year=2000 |pmid=10708863|doi=10.1016/S0167-4838(99)00279-4}}</ref> |
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Overall, all [[Matrix metalloproteinase|MMP]]s are inhibited by TIMPs once they are activated but the [[gelatinase]]s ([[MMP2|MMP-2]] and [[MMP9|MMP-9]]) can form complexes with TIMPs when the enzymes are in the latent form. |
Overall, all [[Matrix metalloproteinase|MMP]]s are inhibited by TIMPs once they are activated but the [[gelatinase]]s ([[MMP2|MMP-2]] and [[MMP9|MMP-9]]) can form complexes with TIMPs when the enzymes are in the latent form. |
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{{reflist|2}} |
{{reflist|2}} |
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* {{MeshName|Tissue+Inhibitor+of+Metalloproteinases}} |
* {{MeshName|Tissue+Inhibitor+of+Metalloproteinases}} |
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[[Category:Human proteins]] |
[[Category:Human proteins]] |
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Revision as of 03:35, 6 June 2016
The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4.[1]
Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP-9) can form complexes with TIMPs when the enzymes are in the latent form.
The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP (MMP-14), a membrane-anchored MMP.
The role of the pro-MMP-9/TIMP-1 complex is still unknown.
References
- ^ Brew K, Dinakarpandian D, Nagase H (2000). "Tissue inhibitors of metalloproteinases: evolution, structure and function". Biochim Biophys Acta. 1477 (1–2): 267–83. doi:10.1016/S0167-4838(99)00279-4. PMID 10708863.
- Tissue+Inhibitor+of+Metalloproteinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)