Interleukin 20: Difference between revisions

IL20
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DOH
Identifiers
Aliases	IL20, IL-20, IL10D, ZCYTO10, Interleukin 20
External IDs	OMIM: 605619; MGI: 1890473; HomoloGene: 10286; GeneCards: IL20; OMA:IL20 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,869,223 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	130,839,188 bp
RNA expression pattern
	Top expressed in
	gonad; ; pancreatic ductal cell; ; seminal vesicula; ; smooth muscle tissue; ; stromal cell of endometrium; ; olfactory zone of nasal mucosa; ; left uterine tube; ; skin of abdomen; ; myometrium; ; skin of limb;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; right ventricle; ; artery; ; mammillary body; ; ventral tegmental area; ; skin of abdomen; ; carotid body; ; major salivary gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	interleukin-20 receptor binding; signaling receptor binding; cytokine activity; interleukin-22 receptor binding; protein binding;
Cellular component	extracellular region; extracellular space;
Biological process	positive regulation of keratinocyte differentiation; positive regulation of osteoclast differentiation; positive regulation of epidermal cell differentiation; regulation of inflammatory response; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	50604
	58181
	ENSG00000162891
	ENSMUSG00000026416
	Q9NYY1
	Q9JKV9
	NM_018724
	NM_021380; NM_001311091
	NP_061194
	NP_001298020; NP_067355
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 11:36, 1 August 2016

Interleukin 20 (IL20) is a protein that in humans is encoded by the IL20 gene.^[5] Interkeukin 20 also includes other cytokines, including IL-19, IL-20, IL-22, IL-24, and IL-26. Based on common structural and functional properties of IL-20's receptors and target cells, these cytokines constitute the same subfamily, IL-20.^[6]

Function

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL-10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.^[5]

Interleukin-20 (IL-20) is a protein belonging to the IL-10 family of cytokines. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells.^[7]

Anti IL-20

Anti-IL-20 monoclonal antibodies have been researched as clinical candidates for the treatment or prevention of psoriasis, rheumatoid arthritis, atherosclerosis, osteoporosis, and stroke.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162891 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026416 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Interleukin 20".
^ Rutz S, Wang X, Ouyang W (Dec 2014). "The IL-20 subfamily of cytokines--from host defence to tissue homeostasis". Nature Reviews. Immunology. 14 (12): 783–95. doi:10.1038/nri3766. PMID 25421700.
^ Rich BE, Kupper TS (August 2006). "Interleukin 20". Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 5 (3): 243–250. doi:10.2174/187152306778017683.
^ Kragstrup TW, Otkjaer K, Holm C, Jørgensen A, Hokland M, Iversen L, Deleuran B (Jan 2008). "The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy". Cytokine. 41 (1): 16–23. doi:10.1016/j.cyto.2007.10.004. PMID 18061474.
^ Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS (Aug 2011). "Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss". The Journal of Experimental Medicine. 208 (9): 1849–61. doi:10.1084/jem.20102234. PMC 3171097. PMID 21844205.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162891 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026416 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Interleukin 20".

[6] Rutz S, Wang X, Ouyang W (Dec 2014). "The IL-20 subfamily of cytokines--from host defence to tissue homeostasis". Nature Reviews. Immunology. 14 (12): 783–95. doi:10.1038/nri3766. PMID 25421700.

[Rich_Kupper_2006-7] Rich BE, Kupper TS (August 2006). "Interleukin 20". Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 5 (3): 243–250. doi:10.2174/187152306778017683.

[8] Kragstrup TW, Otkjaer K, Holm C, Jørgensen A, Hokland M, Iversen L, Deleuran B (Jan 2008). "The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy". Cytokine. 41 (1): 16–23. doi:10.1016/j.cyto.2007.10.004. PMID 18061474.

[9] Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS (Aug 2011). "Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss". The Journal of Experimental Medicine. 208 (9): 1849–61. doi:10.1084/jem.20102234. PMC 3171097. PMID 21844205.

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@@ Line 11: / Line 11: @@
 == Anti IL-20 ==
-Anti-IL-20 monoclonal antibodies have been researched as clinical candidates for the treatment or prevention of psoriasis, rheumatoid arthritis, atherosclerosis, osteoporosis, and stroke.<ref>{{cite journal | vauthors = Kragstrup TW, Otkjaer K, Holm C, Jørgensen A, Hokland M, Iversen L, Deleuran B | title = The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy | journal = Cytokine | volume = 41 | issue = 1 | pages = 16–23 | date = Jan 2008 | pmid = 18061474 | doi = 10.1016/j.cyto.2007.10.004 }}</ref><ref>{{cite journal | vauthors = Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS | title = Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss | journal = The Journal of Experimental Medicine | volume = 208 | issue = 9 | pages = 1849–61 | date = Aug 2011 | pmid = 21844205 | doi = 10.1084/jem.20102234 }}</ref>
+Anti-IL-20 monoclonal antibodies have been researched as clinical candidates for the treatment or prevention of psoriasis, rheumatoid arthritis, atherosclerosis, osteoporosis, and stroke.<ref>{{cite journal | vauthors = Kragstrup TW, Otkjaer K, Holm C, Jørgensen A, Hokland M, Iversen L, Deleuran B | title = The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy | journal = Cytokine | volume = 41 | issue = 1 | pages = 16–23 | date = Jan 2008 | pmid = 18061474 | doi = 10.1016/j.cyto.2007.10.004 }}</ref><ref>{{cite journal | vauthors = Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS | title = Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss | journal = The Journal of Experimental Medicine | volume = 208 | issue = 9 | pages = 1849–61 | date = Aug 2011 | pmid = 21844205 | doi = 10.1084/jem.20102234 | pmc=3171097}}</ref>
 == References ==
 {{Reflist}}
 {{Interleukins}}
 {{Interleukin receptor modulators}}
 {{NLM content}}
+[[Category:Interleukins]]
 {{immunology-stub}}
-[[Category:Interleukins]]