Doramectin: Difference between revisions

Doramectin
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Injection, Topical and Oral
ATCvet code	QP54AA03 (WHO) ;
Legal status
Legal status	Veterinary use only;
Identifiers
	IUPAC name (1'R,2S,4'S,5S,6R,8'R,10'E,12'R,13'S,14'E,20'R,21'R,24'S)-6-cyclohexyl-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one;
CAS Number	117704-25-3 ;
PubChem CID	9832750;
ChemSpider	8008478 ;
UNII	KGD7A54H5P;
KEGG	D01129 ;
CompTox Dashboard (EPA)	DTXSID9048982 ;
ECHA InfoCard	100.123.125
Chemical and physical data
Formula	C50H74O14
Molar mass	899.114 g·mol−1
	InChI InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1 ; Key:QLFZZSKTJWDQOS-YDBLARSUSA-N ;
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Revision as of 20:57, 15 December 2016

Doramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle.^[1]

It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Its spectrum includes: Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus, Psoroptes bovis, among many other internal and external parasites. It is available in 2 dosage forms: as an injection and as a 5 mg/ml topical solution.

Doramectin is also marketed in many Latin-American and some Asia and Africa countries as Doramec L.A. (manufactured by Agrovet Market Animal Health^[2]) in an 1% Doramectin Long Acting Injectable Solution for cattle, sheep, swine^[3] and others. Its oleous carrier confers to Doramec L.A. a slow and prolonged liberation, extending its action up to 42 days.

Doramectin is also available for horses^[3] as an oral flavored bioadhesive gel under the name Doraquest L.A. Oral Gel.^[4] It can be used to control and treat internal parasites as roundworms, lungworms and some external parasites.

References

^ Pfizer Animal Health. "DECTOMAX Injectable." Archived 2007-08-14 at the Wayback Machine Last accessed July 14, 2007.
^ Agrovet Market Animal Health-Doramec L.A.
^ ^a ^b Agrovet Market Animal Health
^ Agrovet Market Animal Health-Doraquest L.A. Oral Gel

[1] Pfizer Animal Health. "DECTOMAX Injectable." Archived 2007-08-14 at the Wayback Machine Last accessed July 14, 2007.

[2] Agrovet Market Animal Health-Doramec L.A.

[Agrovet_Market_Animal_Health_-_Peru-3] Agrovet Market Animal Health

[4] Agrovet Market Animal Health-Doraquest L.A. Oral Gel

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[2]

[3]

[4]

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-'''Doramectin''' ('''Dectomax''') is a [[veterinary drug]] approved by the [[Food and Drug Administration]] (FDA) for the treatment of parasites such as gastrointestinal [[roundworm]]s, [[lungworm]]s, [[eyeworm]]s, [[Larva|grub]]s, [[sucking lice]] and [[mange mite]]s in cattle.<ref>Pfizer Animal Health. [http://www.pfizerah.com/product_overview.asp?drug=DT&country=US&Lang=EN&species=BF "DECTOMAX Injectable."] Last accessed July 14, 2007.</ref>
+'''Doramectin''' ('''Dectomax''') is a [[veterinary drug]] approved by the [[Food and Drug Administration]] (FDA) for the treatment of parasites such as gastrointestinal [[roundworm]]s, [[lungworm]]s, [[eyeworm]]s, [[Larva|grub]]s, [[sucking lice]] and [[mange mite]]s in cattle.<ref>Pfizer Animal Health. [http://www.pfizerah.com/product_overview.asp?drug=DT&country=US&Lang=EN&species=BF "DECTOMAX Injectable."] {{wayback|url=http://www.pfizerah.com/product_overview.asp?drug=DT&country=US&Lang=EN&species=BF |date=20070814064418 }} Last accessed July 14, 2007.</ref>
 It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of [[ivermectin]]. Its spectrum includes: [[Haemonchus]] spp., [[Ostertagia]] spp., [[Trichostrongylus]] spp., [[Cooperia (nematode)|Cooperia]] spp., [[Oesophagostomum]] spp., [[Dictyocaulus viviparus]], [[Dermatobia hominis]], [[Boophilus microplus]], [[Psoroptes bovis]], among many other internal and external parasites.