Talk:Glucosamine

Glucosamine improves joint mobility for 1 in 5 patients with osteoarthritis

On the off chance that anyone around here is interested:

http://www.bmj.com/content/327/7427/0.10

POEM

Glucosamine improves joint mobility for 1 in 5 patients with osteoarthritis

BMJ 2003; 327 doi: http://dx.doi.org/10.1136/bmj.327.7427.0-i (Published 4 December 2003) Cite this as: BMJ 2003;327:0.10

Question Is either glucosamine or chondroitin effective in decreasing symptoms of osteoarthritis?

Synopsis The authors of this meta-analysis searched for all randomised, placebo controlled, clinical trials of either glucosamine or chondroitin for hip or knee arthritis. They did a thorough search of several databases and citation lists of retrieved articles and contacted pharmaceutical companies. They winnowed the 500 initially identified studies to 15 that met their inclusion criteria. These studies enrolled 1775 patients. Both drugs produced a pronounced effect on symptoms as identified by a visual analogue scale (effect size 0.49; 95% confidence interval 0.31 to 0.67) and the Western Ontario McMaster University Osteoarthritis Index, a commonly used measure of pain and physical functioning (0.3; 0.11 to 0.49). Joint mobility also improved markedly (0.59; 0.25 to 0.92) with one person responding for every five patients treated (number needed to treat = 4.9). Adverse effect rates were similar for the drugs and placebo.

Bottom line Glucosamine and chondroitin produce a significant and similar effect on symptoms of osteoarthritis, will improve joint mobility for 1 in 5 patients, and also may slow narrowing of joint spaces. Onset of action is several weeks.

Level of evidence 1a (see www.infopoems.com/resources/levels.html); systematic reviews (with homogeneity) of randomised controlled trials.

Richy F, Bruyere O, Ethgen O, et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis. A comprehensive meta-analysis. Arch Intern Med 2003;163: 1514-2

© infoPOEMs 1992-2003 www.infoPOEMs.com/informationmastery.cfm Footnotes

↵* Patient-Oriented Evidence that Matters. See editorial (BMJ 2002;325: 983 — Preceding unsigned comment added by 68.40.56.234 (talk) 16:09, 11 February 2014 (UTC)

Moved content to Clinical trials on glucosamine and chondroitin

Hello! I just moved the content about osteoarthritis research to Clinical trials on glucosamine and chondroitin. Please go to the talk page of that article for an explanation of why I did this. In short, the information was confusing, beyond the scope of what Wikipedia health articles should cover, and being independently developed in multiple places on Wikipedia. Blue Rasberry (talk) 18:48, 20 May 2014 (UTC)

Love it!!!! Nice to way to solve the thicket of multiple and often conflicting articles covering the same topic. Great. Jytdog (talk) 19:06, 20 May 2014 (UTC)

US Bias

From the medical uses section: "Oral glucosamine is a dietary supplement and is not a pharmaceutical drug. It is illegal in the US to market any dietary supplement as a treatment for any disease or condition.[4]" I understand why this information was included, but why is it included in the first paragraph of the body in isolation from glucosamine's legal/medicinal status in the rest of the English language diaspora? I fear yet more US bias on "English" language wikipedia. 139.218.177.138 (talk) 07:02, 17 January 2015 (UTC)

Could be improved: In the United States, oral glucosamine is a dietary supplement and is not a pharmaceutical drug. It is a prescription drug in some other countries. It is illegal in the U.S. to market any dietary supplement as a treatment for any disease or condition, but it is legal to market a dietary supplement as long as the label does not make a disease claim and also includes the FDA disclaimer statement. For glucosamine, "Helps maintain healthy joints" allowed, while "Restores joint cartilage and cures osteoarthritis" not.David notMD (talk) 11:44, 19 March 2017 (UTC)

Sorry this page sounds like a hit piece

Sorry, this page sounds like a hit piece on glucosamine. There's ample medical evidence that it helps relieve arthritis pains and injuries, and it does not convey this. Instead it sounds like a disclaimer. I call this a hit piece. This is one of the worst pages if come to on wikipedia in years, so biased. Somebody's been paid to do this. — Preceding unsigned comment added by 85.151.139.15 (talk) 20:29, 26 July 2016 (UTC)

It is completely unfounded to claim that this article is the result of someone being paid to write it. In its current state, it has developed over the course of years through the contributions of many editors who voluntarily add to Wikipedia's medical content. (Please see Wikipedia:Assume good faith.) If you would like to suggest specific changes to the article's content, please feel free to do so here. -- Ed (Edgar181) 21:04, 26 July 2016 (UTC)