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'''Membrane steroid receptors''' ('''mSRs'''), also called '''extranuclear steroid receptors''', are a class of [[cell surface receptor]]s activated by [[endogenous]] [[steroid]]s. that bind and are and mediate rapid, [[genome|non-genomic]] [[cell signaling|signaling]] via modulation of [[intracellular signaling cascade]]s.<ref name="pmid24752388">{{vcite2 journal | vauthors = Levin ER | title = Translating extranuclear steroid receptor signaling to clinical medicine | journal = Horm Cancer | volume = 5 | issue = 3 | pages = 140–5 | year = 2014 | pmid = 24752388 | pmc = 4040225 | doi = 10.1007/s12672-014-0179-9 | url = }}</ref><ref name="pmid22028449">{{vcite2 journal | vauthors = Hammes SR, Levin ER | title = Minireview: Recent advances in extranuclear steroid receptor actions | journal = Endocrinology | volume = 152 | issue = 12 | pages = 4489–95 | year = 2011 | pmid = 22028449 | pmc = 3858720 | doi = 10.1210/en.2011-1470 | url = }}</ref><ref name="pmid21354434">{{vcite2 journal | vauthors = Sen A, Prizant H, Hammes SR | title = Understanding extranuclear (nongenomic) androgen signaling: what a frog oocyte can tell us about human biology | journal = Steroids | volume = 76 | issue = 9 | pages = 822–8 | year = 2011 | pmid = 21354434 | doi = 10.1016/j.steroids.2011.02.016 | pmc=4972037}}</ref><ref name="Watson1999">{{cite journal|last1=Watson|first1=C. S.|title=Signaling Themes Shared Between Peptide and Steroid Hormones at the Plasma Membrane|journal=Science Signaling|volume=1999|issue=12|year=1999|pages=pe1–pe1|issn=1945-0877|doi=10.1126/stke.1999.12.pe1}}</ref>
'''Membrane steroid receptors''' ('''mSRs'''), also called '''extranuclear steroid receptors''', are a class of [[cell surface receptor]]s activated by [[endogenous]] [[steroid]]s that mediate rapid, [[genome|non-genomic]] [[cell signaling|signaling]] via modulation of [[intracellular signaling cascade]]s.<ref name="pmid24752388">{{vcite2 journal | vauthors = Levin ER | title = Translating extranuclear steroid receptor signaling to clinical medicine | journal = Horm Cancer | volume = 5 | issue = 3 | pages = 140–5 | year = 2014 | pmid = 24752388 | pmc = 4040225 | doi = 10.1007/s12672-014-0179-9 | url = }}</ref><ref name="pmid22028449">{{vcite2 journal | vauthors = Hammes SR, Levin ER | title = Minireview: Recent advances in extranuclear steroid receptor actions | journal = Endocrinology | volume = 152 | issue = 12 | pages = 4489–95 | year = 2011 | pmid = 22028449 | pmc = 3858720 | doi = 10.1210/en.2011-1470 | url = }}</ref><ref name="pmid21354434">{{vcite2 journal | vauthors = Sen A, Prizant H, Hammes SR | title = Understanding extranuclear (nongenomic) androgen signaling: what a frog oocyte can tell us about human biology | journal = Steroids | volume = 76 | issue = 9 | pages = 822–8 | year = 2011 | pmid = 21354434 | doi = 10.1016/j.steroids.2011.02.016 | pmc=4972037}}</ref><ref name="Watson1999">{{cite journal|last1=Watson|first1=C. S.|title=Signaling Themes Shared Between Peptide and Steroid Hormones at the Plasma Membrane|journal=Science Signaling|volume=1999|issue=12|year=1999|pages=pe1–pe1|issn=1945-0877|doi=10.1126/stke.1999.12.pe1}}</ref>


[[Steroid hormone receptor]]s can produce slow genomic responses or the rapid, non-genomic response in the case of mSRs.<ref name="Conformational">{{cite journal|last1=W.Norman|first1=A.|last2=Mizwicki|first2=M. T.|last3=Norman|first3=D. G.|title=STEROID-HORMONE RAPID ACTIONS, MEMBRANE RECEPTORS AND A CONFORMATIONAL ENSEMBLE MODEL|journal=Nature Reviews Drug Discovery|date=January 2004|volume=3|issue=1|pages=27–41|url=http://www.nature.com/nrd/journal/v3/n1/full/nrd1283.html|accessdate=5 April 2017|doi=10.1038/nrd1283}}</ref>
[[Steroid hormone receptor]]s can produce slow genomic responses or the rapid, non-genomic response in the case of mSRs.<ref name="Conformational">{{cite journal|last1=W.Norman|first1=A.|last2=Mizwicki|first2=M. T.|last3=Norman|first3=D. G.|title=STEROID-HORMONE RAPID ACTIONS, MEMBRANE RECEPTORS AND A CONFORMATIONAL ENSEMBLE MODEL|journal=Nature Reviews Drug Discovery|date=January 2004|volume=3|issue=1|pages=27–41|url=http://www.nature.com/nrd/journal/v3/n1/full/nrd1283.html|accessdate=5 April 2017|doi=10.1038/nrd1283}}</ref>

Revision as of 05:03, 1 May 2017

Membrane steroid receptors (mSRs), also called extranuclear steroid receptors, are a class of cell surface receptors activated by endogenous steroids that mediate rapid, non-genomic signaling via modulation of intracellular signaling cascades.[1][2][3][4]

Steroid hormone receptors can produce slow genomic responses or the rapid, non-genomic response in the case of mSRs.[5] They are another means besides classical nuclear steroid hormone receptors for steroids mediate their biological effects.[1][2][3][4]

Known groups of mSRs include:

References

  1. ^ a b Levin ER (2014). "Translating extranuclear steroid receptor signaling to clinical medicine". Horm Cancer. 5 (3): 140–5. doi:10.1007/s12672-014-0179-9. PMC 4040225. PMID 24752388.
  2. ^ a b Hammes SR, Levin ER (2011). "Minireview: Recent advances in extranuclear steroid receptor actions". Endocrinology. 152 (12): 4489–95. doi:10.1210/en.2011-1470. PMC 3858720. PMID 22028449.
  3. ^ a b Sen A, Prizant H, Hammes SR (2011). "Understanding extranuclear (nongenomic) androgen signaling: what a frog oocyte can tell us about human biology". Steroids. 76 (9): 822–8. doi:10.1016/j.steroids.2011.02.016. PMC 4972037. PMID 21354434.
  4. ^ a b Watson, C. S. (1999). "Signaling Themes Shared Between Peptide and Steroid Hormones at the Plasma Membrane". Science Signaling. 1999 (12): pe1 – pe1. doi:10.1126/stke.1999.12.pe1. ISSN 1945-0877.
  5. ^ W.Norman, A.; Mizwicki, M. T.; Norman, D. G. (January 2004). "STEROID-HORMONE RAPID ACTIONS, MEMBRANE RECEPTORS AND A CONFORMATIONAL ENSEMBLE MODEL". Nature Reviews Drug Discovery. 3 (1): 27–41. doi:10.1038/nrd1283. Retrieved 5 April 2017.


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