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== Draft your article ==
== Draft your article ==
In open [[Microfluidics|'''Microfluidics''']], (open-surface [[microfluidics]] or open-surface [[microfluidics]] one of the boundaries of a channel is removed, so that the system is exposed to air. [[User:Jeileee/sandbox#cite note-:0-1|<sup>[1]</sup>]]One of the many advantages of open channels are ease of accessibility to the flowing liquid, large liquid-gas [[surface area]], robustness, functionality, and ease of fabrication. [[User:Jeileee/sandbox#cite note-:0-1|<sup>[1]</sup>]][[User:Jeileee/sandbox#cite note-:1-2|<sup><nowiki>]</nowiki></sup>]][[User:Jeileee/sandbox#cite note-:2-3|<sup>[3]</sup>]]<ref name=":3">{{Cite journal|last=Casavant|first=Benjamin P.|last2=Berthier|first2=Erwin|last3=Theberge|first3=Ashleigh B.|last4=Berthier|first4=Jean|last5=Montanez-Sauri|first5=Sara I.|last6=Bischel|first6=Lauren L.|last7=Brakke|first7=Kenneth|last8=Hedman|first8=Curtis J.|last9=Bushman|first9=Wade|date=2013-06-18|title=Suspended microfluidics|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690848/|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=110|issue=25|pages=10111–10116|doi=10.1073/pnas.1302566110|issn=0027-8424|pmc=PMC3690848|pmid=23729815}}</ref>Open channels allow the ability of intervening the system at any time, and this is useful to add or remove reagents and samples such as tissues and cells.[[User:Jeileee/sandbox#cite note-:0-1|<sup>[1]</sup>]][[User:Jeileee/sandbox#cite note-:2-3|<sup>[3]</sup>]] 
In open [[Microfluidics|'''Microfluidics''']], (open-surface [[microfluidics]] or open-surface [[microfluidics]] one of the boundaries of a channel is removed, so that the system is exposed to air. One of the many advantages of open channels are ease of accessibility to the flowing liquid, large liquid-gas [[surface area]], robustness, functionality, and ease of fabrication. Open channels allow the ability of intervening the system at any time, and this is useful to add or remove reagents and samples such as tissues and cells.


CE.
CE<ref name=":5">{{Cite journal|last=Gutzweiler|first=Ludwig|last2=Gleichmann|first2=Tobias|last3=Tanguy|first3=Laurent|last4=Koltay|first4=Peter|last5=Zengerle|first5=Roland|last6=Riegger|first6=Lutz|date=2017-04-01|title=Open microfluidic gel electrophoresis: Rapid and low cost separation and analysis of DNA at the nanoliter scale|url=http://onlinelibrary.wiley.com/doi/10.1002/elps.201700001/abstract|journal=ELECTROPHORESIS|language=en|pages=n/a–n/a|doi=10.1002/elps.201700001|issn=1522-2683}}</ref>


In closed channels, air bubles formation could be in an issue, but in open channels this is no longer the case.[[User:Jeileee/sandbox#cite note-:0-1|<sup>[1]</sup>]] In open-channels, the main flow is driven by [[Capillary flow|spontaneous capillary flow]] (SCF).[[User:Jeileee/sandbox#cite note-:0-1|<sup>[1]</sup>]] <ref name=":4">{{Cite journal|last=Kaigala|first=Govind V.|last2=Lovchik|first2=Robert D.|last3=Delamarche|first3=Emmanuel|date=2012-11-05|title=Microfluidics in the “Open Space” for Performing Localized Chemistry on Biological Interfaces|url=http://onlinelibrary.wiley.com/doi/10.1002/anie.201201798/abstract|journal=Angewandte Chemie International Edition|language=en|volume=51|issue=45|pages=11224–11240|doi=10.1002/anie.201201798|issn=1521-3773}}</ref>
In closed channels, air bubles formation could be in an issue, but in open channels this is no longer the case. In open-channels, the main flow is driven by [[Capillary flow|spontaneous capillary flow]] (SCF).


When both the ceiling and floor of a device are removed we will have suspended microfluidics.<ref name=":3" /> The fluid flow is still driven by SCF.
When both the ceiling and floor of a device are removed we will have suspended microfluidics. The fluid flow is still driven by SCF.


Open microfluidics when implemented in the biololyg field can simulate the environment better because of no consraints.<ref name=":4" />
Open microfluidics when implemented in the biololyg field can simulate the environment better because of no consraints.


Microcanal.
Microcanals<ref name=":7">{{Cite journal|last=Hsu|first=Chia-Hsien|last2=Chen|first2=Chihchen|last3=Folch|first3=Albert|date=2004-10-07|title=“Microcanals” for micropipette access to single cells in microfluidic environments|url=http://xlink.rsc.org/?DOI=B404956J|journal=Lab Chip|language=en|volume=4|issue=5|pages=420–424|doi=10.1039/b404956j|issn=1473-0189}}</ref>


moving droplets.
moving droplets <ref name=":6">{{Cite journal|last=Wang|first=Weiqiang|last2=Jones|first2=Thomas B.|date=2015-05-05|title=Moving droplets between closed and open microfluidic systems|url=http://xlink.rsc.org/?DOI=C5LC00014A|journal=Lab Chip|language=en|volume=15|issue=10|pages=2201–2212|doi=10.1039/c5lc00014a|issn=1473-0189}}</ref>


== Draft 1 ==
== Draft 1 ==
Line 44: Line 44:


== Open Microfluidics ==
== Open Microfluidics ==
In open [[microfluidics]], (open-surface [[microfluidics]], open-space [[microfluidics]]), one of the boundaries of a system is removed, and the system is exposed to air or another interface.<ref name=":0">{{Cite book|url=https://www.worldcat.org/oclc/941538295|title=Open Microfluidics.|last=Jean.|first=Berthier,|date=2016-01-01|publisher=John Wiley & Sons|isbn=1118720806|oclc=941538295}}</ref><ref name=":2">{{Cite journal|last=Li|first=C.|last2=Boban|first2=M.|last3=Tuteja|first3=A.|date=2017-04-11|title=Open-channel, water-in-oil emulsification in paper-based microfluidic devices|url=http://xlink.rsc.org/?DOI=C7LC00114B|journal=Lab Chip|language=en|volume=17|issue=8|pages=1436–1441|doi=10.1039/c7lc00114b|issn=1473-0189}}</ref><ref name=":1">{{Cite journal|last=Pfohl|first=Thomas|last2=Mugele|first2=Frieder|last3=Seemann|first3=Ralf|last4=Herminghaus|first4=Stephan|date=2003-12-15|title=Trends in Microfluidics with Complex Fluids|url=http://onlinelibrary.wiley.com/doi/10.1002/cphc.200300847/abstract|journal=ChemPhysChem|language=en|volume=4|issue=12|pages=1291–1298|doi=10.1002/cphc.200300847|issn=1439-7641}}</ref><ref name=":4" />  One of the main advantages of open microfluidics is ease of accessibility and intervention to the flowing liquid in the system at any time, and this is helpful in adding or removing reagents. Compared to a closed system, when of the boundaries of a system is removed, a larger liquid-gas [[surface area]] exists, and this enables gas-liquid reactions to be performed.<ref name=":0" /><ref>{{Cite journal|last=Zhao|first=Bin|last2=Moore|first2=Jeffrey S.|last3=Beebe|first3=David J.|date=2001-02-09|title=Surface-Directed Liquid Flow Inside Microchannels|url=http://science.sciencemag.org/content/291/5506/1023|journal=Science|language=en|volume=291|issue=5506|pages=1023–1026|doi=10.1126/science.291.5506.1023|issn=0036-8075|pmid=11161212}}</ref> and enables optical observation<ref name=":4" /> Open system also eliminates bubble formation, an issue found in closed system.<ref name=":0" /><ref name=":2" />
In open [[microfluidics]], (open-surface [[microfluidics]], open-space [[microfluidics]]), one of the boundaries of a system is removed, and the system is exposed to air or another interface.<ref name=":0">{{Cite book|url=https://www.worldcat.org/oclc/941538295|title=Open Microfluidics.|last=Jean.|first=Berthier,|date=2016-01-01|publisher=John Wiley & Sons|isbn=1118720806|oclc=941538295}}</ref><ref name=":2">{{Cite journal|last=Li|first=C.|last2=Boban|first2=M.|last3=Tuteja|first3=A.|date=2017-04-11|title=Open-channel, water-in-oil emulsification in paper-based microfluidic devices|url=http://xlink.rsc.org/?DOI=C7LC00114B|journal=Lab Chip|language=en|volume=17|issue=8|pages=1436–1441|doi=10.1039/c7lc00114b|issn=1473-0189}}</ref><ref name=":1">{{Cite journal|last=Pfohl|first=Thomas|last2=Mugele|first2=Frieder|last3=Seemann|first3=Ralf|last4=Herminghaus|first4=Stephan|date=2003-12-15|title=Trends in Microfluidics with Complex Fluids|url=http://onlinelibrary.wiley.com/doi/10.1002/cphc.200300847/abstract|journal=ChemPhysChem|language=en|volume=4|issue=12|pages=1291–1298|doi=10.1002/cphc.200300847|issn=1439-7641}}</ref><ref name=":4">{{Cite journal|last=Kaigala|first=Govind V.|last2=Lovchik|first2=Robert D.|last3=Delamarche|first3=Emmanuel|date=2012-11-05|title=Microfluidics in the “Open Space” for Performing Localized Chemistry on Biological Interfaces|url=http://onlinelibrary.wiley.com/doi/10.1002/anie.201201798/abstract|journal=Angewandte Chemie International Edition|language=en|volume=51|issue=45|pages=11224–11240|doi=10.1002/anie.201201798|issn=1521-3773}}</ref>  One of the main advantages of open microfluidics is ease of accessibility and intervention to the flowing liquid in the system at any time, and this is helpful in adding or removing reagents. Compared to a closed system, when of the boundaries of a system is removed, a larger liquid-gas [[surface area]] exists, and this enables gas-liquid reactions to be performed.<ref name=":0" /><ref>{{Cite journal|last=Zhao|first=Bin|last2=Moore|first2=Jeffrey S.|last3=Beebe|first3=David J.|date=2001-02-09|title=Surface-Directed Liquid Flow Inside Microchannels|url=http://science.sciencemag.org/content/291/5506/1023|journal=Science|language=en|volume=291|issue=5506|pages=1023–1026|doi=10.1126/science.291.5506.1023|issn=0036-8075|pmid=11161212}}</ref> and enables optical observation<ref name=":4" /> Open system also eliminates bubble formation, an issue found in closed system.<ref name=":0" /><ref name=":2" />


In closed channel microfluidic devices, the main flow in the channels is usually driven by passive pumping via pumps, external syringes or valves whereas in an open channel system, the flow is driven by [[Capillary flow|spontaneous capillary flow]] (SCF).<ref name=":0" /> The closed channel system will have an inlet port filled with the carrier fluid, and SCF occurs if the [[Laplace pressure]] in the inlet is negative.<ref name=":0" /> Chemical wettability and [[surface modification]] control the flow of the liquid in the channel and allow the fluid to stay confined in the channel.<ref name=":1" /> One of the problem that could occur in an open channel is overflow, and this can be controlled by surface wetting preferentiality where the carrier fluid for example prefers to wet the floor of the channel more than the side walls.<ref name=":2" /> Another problem in an open system is [[evaporation]], but this can be controlled for example by covering the carrier fluid with a film of oil and maintaining the surrounding temperature.<ref name=":5" />
In closed channel microfluidic devices, the main flow in the channels is usually driven by passive pumping via pumps, external syringes or valves whereas in an open channel system, the flow is driven by [[Capillary flow|spontaneous capillary flow]] (SCF).<ref name=":0" /> The closed channel system will have an inlet port filled with the carrier fluid, and SCF occurs if the [[Laplace pressure]] in the inlet is negative.<ref name=":0" /> Chemical wettability and [[surface modification]] control the flow of the liquid in the channel and allow the fluid to stay confined in the channel.<ref name=":1" /> One of the problem that could occur in an open channel is overflow, and this can be controlled by surface wetting preferentiality where the carrier fluid for example prefers to wet the floor of the channel more than the side walls.<ref name=":2" /> Another problem in an open system is [[evaporation]], but this can be controlled for example by covering the carrier fluid with a film of oil and maintaining the surrounding temperature.<ref name=":5">{{Cite journal|last=Gutzweiler|first=Ludwig|last2=Gleichmann|first2=Tobias|last3=Tanguy|first3=Laurent|last4=Koltay|first4=Peter|last5=Zengerle|first5=Roland|last6=Riegger|first6=Lutz|date=2017-04-01|title=Open microfluidic gel electrophoresis: Rapid and low cost separation and analysis of DNA at the nanoliter scale|url=http://onlinelibrary.wiley.com/doi/10.1002/elps.201700001/abstract|journal=ELECTROPHORESIS|language=en|pages=n/a–n/a|doi=10.1002/elps.201700001|issn=1522-2683}}</ref>


The free boundary in open microfluidics allows liquid-liquid and liquid-air interactions, where [[Surface tension|interfacial]] tensions occurs.<ref name=":1" /> When two droplets of different sizes in the channel meet, they will fuse together forming one bigger droplet in the channel due to differences in [[Laplace pressure]].<ref name=":1" /> Therefore, the interfacial surface tensions in the open channel restricts the liquid to be of constant mean [[Curvature of a measure|curvature]] to be stable in the open channel.<ref name=":1" /> Droplet stability can be achieved by applying an [[Electric field|electrical field]].<ref name=":6" /> On the other hand, certain drop shapes observed in closed channels allows for higher [[fluorescence]] sensitivity detection.<ref name=":6" />
The free boundary in open microfluidics allows liquid-liquid and liquid-air interactions, where [[Surface tension|interfacial]] tensions occurs.<ref name=":1" /> When two droplets of different sizes in the channel meet, they will fuse together forming one bigger droplet in the channel due to differences in [[Laplace pressure]].<ref name=":1" /> Therefore, the interfacial surface tensions in the open channel restricts the liquid to be of constant mean [[Curvature of a measure|curvature]] to be stable in the open channel.<ref name=":1" /> Droplet stability can be achieved by applying an [[Electric field|electrical field]].<ref name=":6">{{Cite journal|last=Wang|first=Weiqiang|last2=Jones|first2=Thomas B.|date=2015-05-05|title=Moving droplets between closed and open microfluidic systems|url=http://xlink.rsc.org/?DOI=C5LC00014A|journal=Lab Chip|language=en|volume=15|issue=10|pages=2201–2212|doi=10.1039/c5lc00014a|issn=1473-0189}}</ref> On the other hand, certain drop shapes observed in closed channels allows for higher [[fluorescence]] sensitivity detection.<ref name=":6" />


Like many microfluidics, open system microfluidics can be applied in nanotechnology, biotechnology, fuel cells and space technology.<ref name=":0" /><ref name=":4" /> For cell-based studies, open channels devices allow the access of cells with micropipettes while the cells are in the channel and enables probing of single cells.<ref name=":7" /> Other applications of open microfluidics are open capillary gel electrophoresis, water-in-oil emulsification.<ref name=":5" /><ref name=":2" />
Like many microfluidics, open system microfluidics can be applied in nanotechnology, biotechnology, fuel cells and space technology.<ref name=":0" /><ref name=":4" /> For cell-based studies, open channels devices allow the access of cells with micropipettes while the cells are in the channel and enables probing of single cells.<ref name=":7">{{Cite journal|last=Hsu|first=Chia-Hsien|last2=Chen|first2=Chihchen|last3=Folch|first3=Albert|date=2004-10-07|title=“Microcanals” for micropipette access to single cells in microfluidic environments|url=http://xlink.rsc.org/?DOI=B404956J|journal=Lab Chip|language=en|volume=4|issue=5|pages=420–424|doi=10.1039/b404956j|issn=1473-0189}}</ref> Other applications of open microfluidics are open capillary gel electrophoresis, water-in-oil emulsification.<ref name=":5" /><ref name=":2" />


Other examples of open microfluidics are suspended microfluidics, droplets hanging on wires (fiber/thread/yarn based microfluidics) and channels with comb like rails (rail-based microfluidics and [[Electrowetting|EWOD]]). <ref name=":3" /><ref name=":8">{{Cite journal|last=Lorenceau|first=Élise|last2=Clanet|first2=Christophe|last3=Quéré|first3=David|date=2004-11-01|title=Capturing drops with a thin fiber|url=http://www.sciencedirect.com/science/article/pii/S0021979704005727|journal=Journal of Colloid and Interface Science|volume=279|issue=1|pages=192–197|doi=10.1016/j.jcis.2004.06.054}}</ref><ref name=":9">{{Cite journal|last=Satoh|first=Wataru|last2=Hosono|first2=Hiroki|last3=Suzuki|first3=Hiroaki|date=2005-11-01|title=On-Chip Microfluidic Transport and Mixing Using Electrowetting and Incorporation of Sensing Functions|url=http://dx.doi.org/10.1021/ac050821s|journal=Analytical Chemistry|volume=77|issue=21|pages=6857–6863|doi=10.1021/ac050821s|issn=0003-2700}}</ref> Suspended microfluidic devices have been used in studying cell diffusion and migration.<ref name=":3" /> Rail-based microfluidics device can form microchambers where cells are stored and cell communication is studied.<ref name=":0" />
Other examples of open microfluidics are suspended microfluidics, droplets hanging on wires (fiber/thread/yarn based microfluidics) and channels with comb like rails (rail-based microfluidics and [[Electrowetting|EWOD]]). <ref name=":3">{{Cite journal|last=Casavant|first=Benjamin P.|last2=Berthier|first2=Erwin|last3=Theberge|first3=Ashleigh B.|last4=Berthier|first4=Jean|last5=Montanez-Sauri|first5=Sara I.|last6=Bischel|first6=Lauren L.|last7=Brakke|first7=Kenneth|last8=Hedman|first8=Curtis J.|last9=Bushman|first9=Wade|date=2013-06-18|title=Suspended microfluidics|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690848/|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=110|issue=25|pages=10111–10116|doi=10.1073/pnas.1302566110|issn=0027-8424|pmc=PMC3690848|pmid=23729815}}</ref><ref name=":8">{{Cite journal|last=Lorenceau|first=Élise|last2=Clanet|first2=Christophe|last3=Quéré|first3=David|date=2004-11-01|title=Capturing drops with a thin fiber|url=http://www.sciencedirect.com/science/article/pii/S0021979704005727|journal=Journal of Colloid and Interface Science|volume=279|issue=1|pages=192–197|doi=10.1016/j.jcis.2004.06.054}}</ref><ref name=":9">{{Cite journal|last=Satoh|first=Wataru|last2=Hosono|first2=Hiroki|last3=Suzuki|first3=Hiroaki|date=2005-11-01|title=On-Chip Microfluidic Transport and Mixing Using Electrowetting and Incorporation of Sensing Functions|url=http://dx.doi.org/10.1021/ac050821s|journal=Analytical Chemistry|volume=77|issue=21|pages=6857–6863|doi=10.1021/ac050821s|issn=0003-2700}}</ref> Suspended microfluidic devices have been used in studying cell diffusion and migration.<ref name=":3" /> Rail-based microfluidics device can form microchambers where cells are stored and cell communication is studied.<ref name=":0" />


== Notes ==
== Notes ==

Revision as of 22:15, 14 May 2017

Critique an article

Gluten

Hi,

The first source from FDA is from 2007, it would be best to get an updated version if available since many changes could occur during 10 years of period. The information of source 14, 15, 19, 21 seem to from blog posts and webpages that could be replaced by peer-reviewed articles. The link to source 51,52,53 does not work. Another section that could be added to this article is how gluten is detected. For example an overview of immunological and spectroscopic methods such as gas chromatography, mass spectrometer, ELISA, and commercially available ELISA kit.

Jei1 08:43, 7 April 2017 (UTC)

Add to an article

Microfluidics

In open Microfluidics, (open-surface microfluidics or open-surface microfluidics one of the boundaries of a channel is removed, so that the system is exposed to air. One of the main advantages of open channels are ease of accessibility to the flowing liquid and large liquid-gas surface area. Open channels allow the ability of intervening the system at any time, and this is useful to add or remove reagents. In closed channels, air bubbls formation could be in an issue, but in open channels this is no longer the case. In open-channels, the main flow is driven by spontanous capillary flow. Problem that could arise is evaporation, but that can be solved by maintaining the temperature Droplets can be stabilized by applying an electrical field. When both the top and bottom of a device is removed we will have suspended microfluidics.

Draft your article

In open Microfluidics, (open-surface microfluidics or open-surface microfluidics one of the boundaries of a channel is removed, so that the system is exposed to air. One of the many advantages of open channels are ease of accessibility to the flowing liquid, large liquid-gas surface area, robustness, functionality, and ease of fabrication. Open channels allow the ability of intervening the system at any time, and this is useful to add or remove reagents and samples such as tissues and cells.

CE.

In closed channels, air bubles formation could be in an issue, but in open channels this is no longer the case. In open-channels, the main flow is driven by spontaneous capillary flow (SCF).

When both the ceiling and floor of a device are removed we will have suspended microfluidics. The fluid flow is still driven by SCF.

Open microfluidics when implemented in the biololyg field can simulate the environment better because of no consraints.

Microcanal.

moving droplets.

Draft 1

In open microfluidics, (open-surface microfluidics, open-space microfluidics), one of the boundaries of a system is removed, and the system is exposed to air or another interface. This open boundary is referred to as the free boundary, whereas the other boundaries still in contact with the channel are referred to as the wetted boundaries.One of the main advantages of open microfluidics is the ease of accessibility and intervention to the flowing liquid in the system at any time. In addition, open systems have large liquid-gas surface areas and increased optical capabilities. Open system also eliminates bubble formation, an issue found in closed system.

In closed channel microfluidic devices, the main flow in the channels is usually driven by passive pumping via pumps, external syringes or valves whereas in an open channel system, the flow is driven by spontaneous capillary flow (SCF). The closed channel system will have an inlet port filled with the carrier fluid, and SCF occurs if the Laplace pressure in the inlet is negative. Chemical wettability and surface modification control the flow of the liquid in the channel and allow the fluid to stay confined in the channel. One of the problem that could occur in an open channel is overflow, and this can be controlled by surface wetting preferentiality where the carrier fluid for example prefers to wet the floor of the channel more than the side walls. Another problem in an open system is evaporation, but this can be controlled for example by covering the carrier fluid with a film of oil and maintaining the surrounding temperature.

The free boundary in open microfluidics allows liquid-liquid and liquid-air interactions, where interfacial tensions occurs. When two droplets of different sizes in the channel meet, they will fuse together forming one bigger droplet in the channel due to differences in Laplace pressure. Therefore, the interfacial surface tensions in the open channel restricts the liquid to be of constant mean curvature to be stable in the open channel. Droplet stability can be achieved by applying an electrical field. On the other hand, certain drop shapes observed in closed channels allows for higher fluorescence sensitivity detection.

Like many microfluidics, open system microfluidics can be applied in nanotechnology, biotechnology, fuel cells and space technology. For cell-based studies, open channels devices allow the access of cells with micropipettes while the cells are in the channel and enables probing of single cells. Other applications of open microfluidics are open capillary gel electrophoresis, water-in-oil emulsification.

Other examples of open microfluidics are suspended microfluidics, droplets hanging on wires (fiber/thread/yarn based microfluidics) and channels with comb like rails (rail-based microfluidics and EWOD). Suspended microfluidic devices have been used in studying cell diffusion and migration. Rail-based microfluidics device can form microchambers where cells are stored and cell communication is studied.

Microfluidics

Open Microfluidics

Open Microfluidics

In open microfluidics, (open-surface microfluidics, open-space microfluidics), one of the boundaries of a system is removed, and the system is exposed to air or another interface.[1][2][3][4]  One of the main advantages of open microfluidics is ease of accessibility and intervention to the flowing liquid in the system at any time, and this is helpful in adding or removing reagents. Compared to a closed system, when of the boundaries of a system is removed, a larger liquid-gas surface area exists, and this enables gas-liquid reactions to be performed.[1][5] and enables optical observation[4] Open system also eliminates bubble formation, an issue found in closed system.[1][2]

In closed channel microfluidic devices, the main flow in the channels is usually driven by passive pumping via pumps, external syringes or valves whereas in an open channel system, the flow is driven by spontaneous capillary flow (SCF).[1] The closed channel system will have an inlet port filled with the carrier fluid, and SCF occurs if the Laplace pressure in the inlet is negative.[1] Chemical wettability and surface modification control the flow of the liquid in the channel and allow the fluid to stay confined in the channel.[3] One of the problem that could occur in an open channel is overflow, and this can be controlled by surface wetting preferentiality where the carrier fluid for example prefers to wet the floor of the channel more than the side walls.[2] Another problem in an open system is evaporation, but this can be controlled for example by covering the carrier fluid with a film of oil and maintaining the surrounding temperature.[6]

The free boundary in open microfluidics allows liquid-liquid and liquid-air interactions, where interfacial tensions occurs.[3] When two droplets of different sizes in the channel meet, they will fuse together forming one bigger droplet in the channel due to differences in Laplace pressure.[3] Therefore, the interfacial surface tensions in the open channel restricts the liquid to be of constant mean curvature to be stable in the open channel.[3] Droplet stability can be achieved by applying an electrical field.[7] On the other hand, certain drop shapes observed in closed channels allows for higher fluorescence sensitivity detection.[7]

Like many microfluidics, open system microfluidics can be applied in nanotechnology, biotechnology, fuel cells and space technology.[1][4] For cell-based studies, open channels devices allow the access of cells with micropipettes while the cells are in the channel and enables probing of single cells.[8] Other applications of open microfluidics are open capillary gel electrophoresis, water-in-oil emulsification.[6][2]

Other examples of open microfluidics are suspended microfluidics, droplets hanging on wires (fiber/thread/yarn based microfluidics) and channels with comb like rails (rail-based microfluidics and EWOD). [9][10][11] Suspended microfluidic devices have been used in studying cell diffusion and migration.[9] Rail-based microfluidics device can form microchambers where cells are stored and cell communication is studied.[1]

Notes

  1. ^ a b c d e f g Jean., Berthier, (2016-01-01). Open Microfluidics. John Wiley & Sons. ISBN 1118720806. OCLC 941538295.{{cite book}}: CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)
  2. ^ a b c d Li, C.; Boban, M.; Tuteja, A. (2017-04-11). "Open-channel, water-in-oil emulsification in paper-based microfluidic devices". Lab Chip. 17 (8): 1436–1441. doi:10.1039/c7lc00114b. ISSN 1473-0189.
  3. ^ a b c d e Pfohl, Thomas; Mugele, Frieder; Seemann, Ralf; Herminghaus, Stephan (2003-12-15). "Trends in Microfluidics with Complex Fluids". ChemPhysChem. 4 (12): 1291–1298. doi:10.1002/cphc.200300847. ISSN 1439-7641.
  4. ^ a b c Kaigala, Govind V.; Lovchik, Robert D.; Delamarche, Emmanuel (2012-11-05). "Microfluidics in the "Open Space" for Performing Localized Chemistry on Biological Interfaces". Angewandte Chemie International Edition. 51 (45): 11224–11240. doi:10.1002/anie.201201798. ISSN 1521-3773.
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