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==Interactions==
==Interactions==
CDC25B has been shown to [[Protein-protein interaction|interact]] with [[MAPK14]],<ref name=pmid11333986>{{cite journal |last=Bulavin |first=D V |author2=Higashimoto Y|author3=Popoff I J|author4=Gaarde W A|author5=Basrur V|author6=Potapova O|author7=Appella E|author8=Fornace A J |date=May 2001 |title=Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase |journal=[[Nature (journal)|Nature]] |volume=411 |issue=6833 |pages=102–7 |publisher= |location = England| issn = 0028-0836| pmid = 11333986 |doi = 10.1038/35075107 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Casein kinase 2, alpha 1]],<ref name=pmid12527891>{{cite journal |last=Theis-Febvre |first=Nathalie |author2=Filhol Odile |author3=Froment Carine |author4=Cazales Martine |author5=Cochet Claude |author6=Monsarrat Bernard |author7=Ducommun Bernard |author8=Baldin Véronique |date=January 2003 |title=Protein kinase CK2 regulates CDC25B phosphatase activity |journal=Oncogene |volume=22 |issue=2 |pages=220–32 |publisher= |location = England| issn = 0950-9232| pmid = 12527891 |doi = 10.1038/sj.onc.1206107 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[CHEK1]],<ref name=pmid9278511>{{cite journal |last=Sanchez |first=Y |author2=Wong C|author3=Thoma R S|author4=Richman R|author5=Wu Z|author6=Piwnica-Worms H|author7=Elledge S J |date=September 1997 |title=Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 |journal=[[Science (journal)|Science]] |volume=277 |issue=5331 |pages=1497–501 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 9278511 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi = 10.1126/science.277.5331.1497 }}</ref> [[MELK]],<ref name=pmid12400006>{{cite journal |last=Davezac |first=Noélie |author2=Baldin Véronique |author3=Blot Joëlle |author4=Ducommun Bernard |author5=Tassan Jean-Pierre |date=October 2002 |title=Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation |journal=Oncogene |volume=21 |issue=50 |pages=7630–41 |publisher= |location = England| issn = 0950-9232| pmid = 12400006 |doi = 10.1038/sj.onc.1205870 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Estrogen receptor alpha]],<ref name=pmid11689696>{{cite journal |last=Ma |first=Z Q |author2=Liu Z|author3=Ngan E S|author4=Tsai S Y |date=December 2001 |title=Cdc25B Functions as a Novel Coactivator for the Steroid Receptors |journal=Mol. Cell. Biol. |volume=21 |issue=23 |pages=8056–67 |publisher= |location = United States| issn = 0270-7306| pmid = 11689696 |doi = 10.1128/MCB.21.23.8056-8067.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | pmc = 99972 }}</ref> [[YWHAB]],<ref name=pmid10713667>{{cite journal |last=Mils |first=V |author2=Baldin V|author3=Goubin F|author4=Pinta I|author5=Papin C|author6=Waye M|author7=Eychene A|author8=Ducommun B |date=March 2000 |title=Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase |journal=Oncogene |volume=19 |issue=10 |pages=1257–65 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10713667 |doi = 10.1038/sj.onc.1203419 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid7644510>{{cite journal |last=Conklin |first=D S |author2=Galaktionov K|author3=Beach D |date=August 1995 |title=14-3-3 proteins associate with cdc25 phosphatases |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=92 |issue=17 |pages=7892–6 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 7644510 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi = 10.1073/pnas.92.17.7892 | pmc = 41252 }}</ref> [[YWHAZ]],<ref name=pmid10713667/> [[YWHAH]]<ref name=pmid10713667/> and [[YWHAE]].<ref name=pmid10713667/><ref name=pmid7644510/>
CDC25B has been shown to [[Protein-protein interaction|interact]] with [[MAPK14]],<ref name=pmid11333986>{{cite journal |last=Bulavin |first=D V |author2=Higashimoto Y|author3=Popoff I J|author4=Gaarde W A|author5=Basrur V|author6=Potapova O|author7=Appella E|author8=Fornace A J |date=May 2001 |title=Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase |journal=[[Nature (journal)|Nature]] |volume=411 |issue=6833 |pages=102–7 |publisher= |location = England| issn = 0028-0836| pmid = 11333986 |doi = 10.1038/35075107 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Casein kinase 2, alpha 1]],<ref name=pmid12527891>{{cite journal |last=Theis-Febvre |first=Nathalie |author2=Filhol Odile |author3=Froment Carine |author4=Cazales Martine |author5=Cochet Claude |author6=Monsarrat Bernard |author7=Ducommun Bernard |author8=Baldin Véronique |date=January 2003 |title=Protein kinase CK2 regulates CDC25B phosphatase activity |journal=Oncogene |volume=22 |issue=2 |pages=220–32 |publisher= |location = England| issn = 0950-9232| pmid = 12527891 |doi = 10.1038/sj.onc.1206107 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[CHEK1]],<ref name=pmid9278511>{{cite journal |last=Sanchez |first=Y |author2=Wong C|author3=Thoma R S|author4=Richman R|author5=Wu Z|author6=Piwnica-Worms H|author7=Elledge S J |date=September 1997 |title=Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 |journal=[[Science (journal)|Science]] |volume=277 |issue=5331 |pages=1497–501 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 9278511 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi = 10.1126/science.277.5331.1497 }}</ref> [[MELK]],<ref name=pmid12400006>{{cite journal |last=Davezac |first=Noélie |author2=Baldin Véronique |author3=Blot Joëlle |author4=Ducommun Bernard |author5=Tassan Jean-Pierre |date=October 2002 |title=Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation |journal=Oncogene |volume=21 |issue=50 |pages=7630–41 |publisher= |location = England| issn = 0950-9232| pmid = 12400006 |doi = 10.1038/sj.onc.1205870 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Estrogen receptor alpha]],<ref name=pmid11689696>{{cite journal |last=Ma |first=Z Q |author2=Liu Z|author3=Ngan E S|author4=Tsai S Y |date=December 2001 |title=Cdc25B Functions as a Novel Coactivator for the Steroid Receptors |journal=Mol. Cell. Biol. |volume=21 |issue=23 |pages=8056–67 |publisher= |location = United States| issn = 0270-7306| pmid = 11689696 |doi = 10.1128/MCB.21.23.8056-8067.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | pmc = 99972 }}</ref> [[YWHAB]],<ref name=pmid10713667>{{cite journal |last=Mils |first=V |author2=Baldin V|author3=Goubin F|author4=Pinta I|author5=Papin C|author6=Waye M|author7=Eychene A|author8=Ducommun B |date=March 2000 |title=Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase |journal=Oncogene |volume=19 |issue=10 |pages=1257–65 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10713667 |doi = 10.1038/sj.onc.1203419 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid7644510>{{cite journal |last=Conklin |first=D S |author2=Galaktionov K|author3=Beach D |date=August 1995 |title=14-3-3 proteins associate with cdc25 phosphatases |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=92 |issue=17 |pages=7892–6 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 7644510 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi = 10.1073/pnas.92.17.7892 | pmc = 41252 }}</ref> [[YWHAZ]],<ref name=pmid10713667/> [[YWHAH]]<ref name=pmid10713667/> and [[YWHAE]].<ref name=pmid10713667/><ref name=pmid7644510/> Function of CDC25B gene can be effectively examined by siRNA knockdown based on an independent validation.<ref>{{Cite journal|last=Munkácsy|first=Gyöngyi|last2=Sztupinszki|first2=Zsófia|last3=Herman|first3=Péter|last4=Bán|first4=Bence|last5=Pénzváltó|first5=Zsófia|last6=Szarvas|first6=Nóra|last7=Győrffy|first7=Balázs|date=2016-01-01|title=Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments|url=http://linkinghub.elsevier.com/retrieve/pii/S2162253117300859|journal=Molecular Therapy - Nucleic Acids|language=English|volume=5|doi=10.1038/mtna.2016.66|issn=2162-2531|pmc=PMC5056990|pmid=27673562}}</ref>


==References==
==References==

Revision as of 09:22, 8 June 2017

CDC25B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDC25B, cell division cycle 25B
External IDsOMIM: 116949; MGI: 99701; HomoloGene: 41451; GeneCards: CDC25B; OMA:CDC25B - orthologs
Orthologs
SpeciesHumanMouse
Entrez

994

12531

Ensembl

ENSG00000101224

ENSMUSG00000027330

UniProt

P30305

P30306

RefSeq (mRNA)

NM_001111075
NM_023117

RefSeq (protein)

NP_001104545
NP_075606

Location (UCSC)Chr 20: 3.79 – 3.81 MbChr 2: 131.03 – 131.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.[5]

Template:PBB Summary

Interactions

CDC25B has been shown to interact with MAPK14,[6] Casein kinase 2, alpha 1,[7] CHEK1,[8] MELK,[9] Estrogen receptor alpha,[10] YWHAB,[11][12] YWHAZ,[11] YWHAH[11] and YWHAE.[11][12] Function of CDC25B gene can be effectively examined by siRNA knockdown based on an independent validation.[13]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101224 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027330 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Galaktionov K, Beach D (February 1992). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins". Cell. 67 (6): 1181–94. doi:10.1016/0092-8674(91)90294-9. PMID 1836978.
  6. ^ Bulavin, D V; Higashimoto Y; Popoff I J; Gaarde W A; Basrur V; Potapova O; Appella E; Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature. 411 (6833). England: 102–7. doi:10.1038/35075107. ISSN 0028-0836. PMID 11333986. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  7. ^ Theis-Febvre, Nathalie; Filhol Odile; Froment Carine; Cazales Martine; Cochet Claude; Monsarrat Bernard; Ducommun Bernard; Baldin Véronique (January 2003). "Protein kinase CK2 regulates CDC25B phosphatase activity". Oncogene. 22 (2). England: 220–32. doi:10.1038/sj.onc.1206107. ISSN 0950-9232. PMID 12527891. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  8. ^ Sanchez, Y; Wong C; Thoma R S; Richman R; Wu Z; Piwnica-Worms H; Elledge S J (September 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science. 277 (5331). UNITED STATES: 1497–501. doi:10.1126/science.277.5331.1497. ISSN 0036-8075. PMID 9278511. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  9. ^ Davezac, Noélie; Baldin Véronique; Blot Joëlle; Ducommun Bernard; Tassan Jean-Pierre (October 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50). England: 7630–41. doi:10.1038/sj.onc.1205870. ISSN 0950-9232. PMID 12400006. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  10. ^ Ma, Z Q; Liu Z; Ngan E S; Tsai S Y (December 2001). "Cdc25B Functions as a Novel Coactivator for the Steroid Receptors". Mol. Cell. Biol. 21 (23). United States: 8056–67. doi:10.1128/MCB.21.23.8056-8067.2001. ISSN 0270-7306. PMC 99972. PMID 11689696. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)
  11. ^ a b c d Mils, V; Baldin V; Goubin F; Pinta I; Papin C; Waye M; Eychene A; Ducommun B (March 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10). ENGLAND: 1257–65. doi:10.1038/sj.onc.1203419. ISSN 0950-9232. PMID 10713667. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  12. ^ a b Conklin, D S; Galaktionov K; Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17). UNITED STATES: 7892–6. doi:10.1073/pnas.92.17.7892. ISSN 0027-8424. PMC 41252. PMID 7644510. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
  13. ^ Munkácsy, Gyöngyi; Sztupinszki, Zsófia; Herman, Péter; Bán, Bence; Pénzváltó, Zsófia; Szarvas, Nóra; Győrffy, Balázs (2016-01-01). "Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments". Molecular Therapy - Nucleic Acids. 5. doi:10.1038/mtna.2016.66. ISSN 2162-2531. PMC 5056990. PMID 27673562.{{cite journal}}: CS1 maint: PMC format (link)

Further reading

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