RAPGEF5: Difference between revisions

RAPGEF5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGY
Identifiers
Aliases	RAPGEF5, GFR, MR-GEF, REPAC, Rap guanine nucleotide exchange factor 5, MRGEF
External IDs	OMIM: 609527; MGI: 2444365; HomoloGene: 56563; GeneCards: RAPGEF5; OMA:RAPGEF5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	22,357,154 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	117,723,472 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; Pons; ; inferior olivary nucleus; ; corpus callosum; ; superior vestibular nucleus; ; pars reticulata; ; subthalamic nucleus; ; postcentral gyrus; ; external globus pallidus; ; dorsal motor nucleus of vagus nerve;
	Top expressed in
	superior cervical ganglion; ; otolith organ; ; utricle; ; anterior amygdaloid area; ; right lung; ; lateral septal nucleus; ; zygote; ; left lung lobe; ; oocyte; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTP-dependent protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	nucleus; nucleoplasm; nuclear body;
Biological process	small GTPase mediated signal transduction; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	9771
	217944
	ENSG00000136237
	ENSMUSG00000041992
	Q92565
	Q8C0Q9
	NM_012294; NM_001367600; NM_001367601; NM_001367602; NM_001367603
	NM_175930; NM_001373989
	NP_036426; NP_001354529; NP_001354530; NP_001354531; NP_001354532
	NP_787126; NP_001360918
	Wikidata
View/Edit Human	View/Edit Mouse

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Inline

Revision as of 13:10, 21 February 2018

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136237 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041992 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
^ Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y (Oct 1999). "Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1". FEBS Lett. 457 (1): 85–9. doi:10.1016/S0014-5793(99)01012-1. PMID 10486569.
^ "Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5".

@@ Line 5: / Line 5: @@
 {{PBB_Summary
 | section_title =
-| summary_text = Members of the [[Ras subfamily|RAS subfamily]] (see [[HRAS]]; MIM 190020) of [[GTPases]] function in [[signal transduction]] as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. [[Guanine nucleotide exchange factors]] (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of [[GTP]] to maintain the active GTP-bound state and are the key link between [[cell surface receptors]] and RAS activation (Rebhun et al., 2000).[supplied by OMIM]<ref name="entrez" />
+| summary_text = Members of the [[Ras subfamily|RAS subfamily]] (see [[HRAS]]; MIM 190020) of [[GTPases]] function in [[signal transduction]] as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. [[Guanine nucleotide exchange factors]] (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of [[Guanosine triphosphate|GTP]] to maintain the active GTP-bound state and are the key link between [[cell surface receptors]] and RAS activation (Rebhun et al., 2000).[supplied by OMIM]<ref name="entrez" />
 }}