GNA12: Difference between revisions
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'''Guanine nucleotide-binding protein subunit alpha-12''' is a [[protein]] that in humans is encoded by the ''GNA12'' [[gene]].<ref name="pmid8423800">{{cite journal | vauthors = Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA | title = Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product | journal = Molecular and Cellular Biology | volume = 13 | issue = 2 | pages = 762–8 | date = February 1993 | pmid = 8423800 | pmc = 358958 | doi = }}</ref><ref name="pmid16247467">{{cite journal | vauthors = Kumar RN, Shore SK, Dhanasekaran N | title = Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3 | journal = Oncogene | volume = 25 | issue = 6 | pages = 899–906 | date = February 2006 | pmid = 16247467 | pmc = | doi = 10.1038/sj.onc.1209132 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2768| accessdate = }}</ref> |
'''Guanine nucleotide-binding protein subunit alpha-12''' is a [[protein]] that in humans is encoded by the ''GNA12'' [[gene]].<ref name="pmid8423800">{{cite journal | vauthors = Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA | title = Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product | journal = Molecular and Cellular Biology | volume = 13 | issue = 2 | pages = 762–8 | date = February 1993 | pmid = 8423800 | pmc = 358958 | doi = 10.1128/mcb.13.2.762}}</ref><ref name="pmid16247467">{{cite journal | vauthors = Kumar RN, Shore SK, Dhanasekaran N | title = Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3 | journal = Oncogene | volume = 25 | issue = 6 | pages = 899–906 | date = February 2006 | pmid = 16247467 | pmc = | doi = 10.1038/sj.onc.1209132 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2768| accessdate = }}</ref> |
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Revision as of 12:00, 4 March 2018
Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.[5][6][7]
Interactions
GNA12 has been shown to interact with ARHGEF1,[8] PPP5C,[9] ARHGEF12,[10][11] HSP90[12], Resistance to inhibitors of cholinesterase-8A (Ric-8A) [13] and TEC.[11]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000146535 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000149 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Molecular and Cellular Biology. 13 (2): 762–8. doi:10.1128/mcb.13.2.762. PMC 358958. PMID 8423800.
- ^ Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene. 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467.
- ^ "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12".
- ^ Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.
- ^ Yamaguchi Y, Katoh H, Mori K, Negishi M (August 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367.
- ^ Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters. 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164.
- ^ a b Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
- ^ Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA (December 2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". The Journal of Biological Chemistry. 276 (49): 46088–93. doi:10.1074/jbc.M108711200. PMID 11598136.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi:10.1074/jbc.M111.253427. PMID 21771786.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
External links
- GNA12+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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