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== Interactions ==
== Interactions ==


GNA12 has been shown to [[Protein-protein interaction|interact]] with [[ARHGEF1]],<ref name=pmid14634662>{{cite journal | vauthors = Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM | title = RGS16 inhibits signalling through the G alpha 13-Rho axis | journal = Nature Cell Biology | volume = 5 | issue = 12 | pages = 1095–103 | date = December 2003 | pmid = 14634662 | doi = 10.1038/ncb1065 }}</ref> [[PPP5C]],<ref name=pmid12176367>{{cite journal | vauthors = Yamaguchi Y, Katoh H, Mori K, Negishi M | title = Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity | journal = Current Biology | volume = 12 | issue = 15 | pages = 1353–8 | date = August 2002 | pmid = 12176367 | doi = 10.1016/S0960-9822(02)01034-5 }}</ref> [[ARHGEF12]],<ref name=pmid11094164>{{cite journal | vauthors = Fukuhara S, Chikumi H, Gutkind JS | title = Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho | journal = FEBS Letters | volume = 485 | issue = 2-3 | pages = 183–8 | date = November 2000 | pmid = 11094164 | doi = 10.1016/S0014-5793(00)02224-9 }}</ref><ref name=pmid12515866>{{cite journal | vauthors = Suzuki N, Nakamura S, Mano H, Kozasa T | title = Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 2 | pages = 733–8 | date = January 2003 | pmid = 12515866 | pmc = 141065 | doi = 10.1073/pnas.0234057100 }}</ref> [[HSP90]]<ref name=pmid11598136>{{cite journal | vauthors = Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA | title = Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling | journal = The Journal of Biological Chemistry | volume = 276 | issue = 49 | pages = 46088–93 | date = December 2001 | pmid = 11598136 | doi = 10.1074/jbc.M108711200 }}</ref>, Resistance to inhibitors of cholinesterase-8A (Ric-8A) <ref name=pmid21771786>{{cite journal | vauthors = Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY | title = Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization | journal = The Journal of Biological Chemistry | volume = 286 | issue = 35 | pages = 31055–61 | date = September 2011 | pmid = 21771786 | doi = 10.1074/jbc.M111.253427 }}</ref> and [[TEC (gene)|TEC]].<ref name=pmid12515866/>
GNA12 has been shown to [[Protein-protein interaction|interact]] with [[ARHGEF1]],<ref name=pmid14634662>{{cite journal | vauthors = Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM | title = RGS16 inhibits signalling through the G alpha 13-Rho axis | journal = Nature Cell Biology | volume = 5 | issue = 12 | pages = 1095–103 | date = December 2003 | pmid = 14634662 | doi = 10.1038/ncb1065 }}</ref> [[PPP5C]],<ref name=pmid12176367>{{cite journal | vauthors = Yamaguchi Y, Katoh H, Mori K, Negishi M | title = Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity | journal = Current Biology | volume = 12 | issue = 15 | pages = 1353–8 | date = August 2002 | pmid = 12176367 | doi = 10.1016/S0960-9822(02)01034-5 }}</ref> [[ARHGEF12]],<ref name=pmid11094164>{{cite journal | vauthors = Fukuhara S, Chikumi H, Gutkind JS | title = Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho | journal = FEBS Letters | volume = 485 | issue = 2–3 | pages = 183–8 | date = November 2000 | pmid = 11094164 | doi = 10.1016/S0014-5793(00)02224-9 }}</ref><ref name=pmid12515866>{{cite journal | vauthors = Suzuki N, Nakamura S, Mano H, Kozasa T | title = Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 2 | pages = 733–8 | date = January 2003 | pmid = 12515866 | pmc = 141065 | doi = 10.1073/pnas.0234057100 }}</ref> [[HSP90]]<ref name=pmid11598136>{{cite journal | vauthors = Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA | title = Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling | journal = The Journal of Biological Chemistry | volume = 276 | issue = 49 | pages = 46088–93 | date = December 2001 | pmid = 11598136 | doi = 10.1074/jbc.M108711200 }}</ref>, Resistance to inhibitors of cholinesterase-8A (Ric-8A) <ref name=pmid21771786>{{cite journal | vauthors = Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY | title = Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization | journal = The Journal of Biological Chemistry | volume = 286 | issue = 35 | pages = 31055–61 | date = September 2011 | pmid = 21771786 | doi = 10.1074/jbc.M111.253427 | pmc=3162464}}</ref> and [[TEC (gene)|TEC]].<ref name=pmid12515866/>


== See also ==
== See also ==

Revision as of 13:01, 5 March 2018

GNA12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGNA12, NNX3, RMP, gep, G protein subunit alpha 12, HG1M1
External IDsOMIM: 604394; MGI: 95767; HomoloGene: 22398; GeneCards: GNA12; OMA:GNA12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

2768

14673

Ensembl

ENSG00000146535

ENSMUSG00000000149

UniProt

Q03113

P27600

RefSeq (mRNA)

NM_001282440
NM_001282441
NM_001293092
NM_007353

NM_010302

RefSeq (protein)

NP_001269369
NP_001269370
NP_001280021
NP_031379

NP_034432

Location (UCSC)Chr 7: 2.73 – 2.84 MbChr 5: 140.74 – 140.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.[5][6][7]


Interactions

GNA12 has been shown to interact with ARHGEF1,[8] PPP5C,[9] ARHGEF12,[10][11] HSP90[12], Resistance to inhibitors of cholinesterase-8A (Ric-8A) [13] and TEC.[11]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146535 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000149 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Molecular and Cellular Biology. 13 (2): 762–8. doi:10.1128/mcb.13.2.762. PMC 358958. PMID 8423800.
  6. ^ Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene. 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467.
  7. ^ "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12".
  8. ^ Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.
  9. ^ Yamaguchi Y, Katoh H, Mori K, Negishi M (August 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367.
  10. ^ Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters. 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164.
  11. ^ a b Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
  12. ^ Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA (December 2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". The Journal of Biological Chemistry. 276 (49): 46088–93. doi:10.1074/jbc.M108711200. PMID 11598136.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  13. ^ Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi:10.1074/jbc.M111.253427. PMC 3162464. PMID 21771786.{{cite journal}}: CS1 maint: unflagged free DOI (link)


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