CAMK4: Difference between revisions

CAMK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2W4O
Identifiers
Aliases	CAMK4, CaMK IV, CaMK-GR, IV, caMK, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin dependent protein kinase IV, CaMKIV
External IDs	OMIM: 114080; MGI: 88258; HomoloGene: 100780; GeneCards: CAMK4; OMA:CAMK4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	111,494,886 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	33,324,281 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; middle temporal gyrus; ; left testis; ; right testis; ; paraflocculus of cerebellum; ; ganglionic eminence; ; nucleus accumbens; ; superior frontal gyrus;
	Top expressed in
	cerebellar cortex; ; superior frontal gyrus; ; thymus; ; primary visual cortex; ; lobe of cerebellum; ; seminiferous tubule; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar vermis; ; spermatid; ; olfactory tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; kinase activity; protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity; ATP binding;
Cellular component	cytoplasm; cytosol; nucleoplasm; extracellular exosome; nucleus; fibrillar center; postsynapse; glutamatergic synapse;
Biological process	intracellular signal transduction; adaptive immune response; myeloid dendritic cell cytokine production; phosphorylation; immune system process; myeloid dendritic cell differentiation; positive regulation of transcription, DNA-templated; regulation of T cell differentiation in thymus; protein phosphorylation; regulation of osteoclast differentiation; long-term memory; peptidyl-serine phosphorylation; protein autophosphorylation; inflammatory response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	814
	12326
	ENSG00000152495
	ENSMUSG00000038128
	Q16566
	P08414; Q8BGR3
	NM_001744; NM_001323374; NM_001323375; NM_001323376; NM_001323377
	NM_009793
	NP_001310303; NP_001310304; NP_001310305; NP_001310306; NP_001735
	NP_033923
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 05:50, 27 June 2018

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.^[5]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152495 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038128 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sikela JM, Law ML, Kao FT, Hartz JA, Wei Q, Hahn WE (Mar 1989). "Chromosomal localization of the human gene for brain Ca²⁺/calmodulin-dependent protein kinase type IV". Genomics. 4 (1): 21–7. doi:10.1016/0888-7543(89)90309-1. PMID 2536634.

External links

Human CAMK4 genome location and CAMK4 gene details page in the UCSC Genome Browser.

Template:PBB Controls

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152495 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038128 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2536634-5] Sikela JM, Law ML, Kao FT, Hartz JA, Wei Q, Hahn WE (Mar 1989). "Chromosomal localization of the human gene for brain Ca²⁺/calmodulin-dependent protein kinase type IV". Genomics. 4 (1): 21–7. doi:10.1016/0888-7543(89)90309-1. PMID 2536634.

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@@ Line 1: / Line 1: @@
-{{Underlinked|date=May 2016}}
 {{Infobox_gene}}
 '''Calcium/calmodulin-dependent protein kinase type IV''' is an [[enzyme]] that in humans is encoded by the ''CAMK4'' [[gene]].<ref name="pmid2536634">{{cite journal | vauthors = Sikela JM, Law ML, Kao FT, Hartz JA, Wei Q, Hahn WE | title = Chromosomal localization of the human gene for brain Ca<sup>2+</sup>/calmodulin-dependent protein kinase type IV | journal = Genomics | volume = 4 | issue = 1 | pages = 21–7 |date=Mar 1989 | pmid = 2536634 | pmc = | doi =10.1016/0888-7543(89)90309-1 }}</ref>
@@ Line 6: / Line 5: @@
 {{PBB_Summary
 | section_title =
-| summary_text = The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca<sup>2+</sup>/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.<ref name="entrez">{{cite web | title = Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=814| accessdate = }}</ref>
+| summary_text = The product of this gene belongs to the [[serine/threonine protein kinase]] family, and to the [[CAMK|Ca<sup>2+</sup>/calmodulin-dependent protein kinase]] (CAMK) subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in [[lymphocytes]], [[neurons]], and [[gamete|male germ cells]].<ref name="entrez">{{cite web | title = Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=814| accessdate = }}</ref>
 }}

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Revision as of 05:50, 27 June 2018

References

Further reading

External links