Template talk:Estradiol metabolism

Syntax for page-specific annotation rendering:

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Putting this here temporarily. Seppi333 (Insert 2¢) 21:05, 8 August 2018 (UTC)

Feedback

@Medgirl131: I've made the changes you indicated. If you have any other suggestions/feedback for the background image file, feel free to follow up via email and let me know; if you think it looks good now, I'll start annotating wikitext. Seppi333 (Insert 2¢) 19:23, 8 August 2018 (UTC)

I went ahead and added the annotations since I'd still be using the same approximate coordinates for an annotation regardless of whether I end up swapping one compound with another. The enzyme labels still need to be added; a few minor tweaks the the enzyme annotation coordinates will probably be necessary once that's done. Seppi333 (Insert 2¢) 22:18, 8 August 2018 (UTC)

BRENDA ligand entries for Homo sapiens

17β-Estradiol → Estrone

• EC 1.1.1.35 - [1]
• EC 1.1.1.50 - [2]
• EC 1.1.1.51 - [3]
• EC 1.1.1.62 - [4]: indicates 17β-HSD2, 17β-HSD4, and 17β-HSD5 are involved in this reaction and 17β-HSD1 is the predominant mediator of the reverse reaction.
• EC 1.1.1.239 - [5]
• EC 1.1.1.357 - [6]

Estrone

• EC 1.1.1.
• EC 1.1.1.
• EC 1.1.1.
• EC 1.1.1.239 - [7]
• EC 1.1.1.357 - [8]

Estrone sulfation:

• EC 2.8.2.2 [9]
• EC 2.8.2.4 "high activity by SULT1E1, low activity by phenol sulfotransferase SULT1A1, EC 2.8.2.1" (SULT1E1 = EST) - [10]

Estrone glucuronidation:

• EC 2.4.1.17 "glucuronidated by UGT1A3 and HGT1A9" - [11]