Template talk:Estradiol metabolism: Difference between revisions

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Feedback

@Medgirl131: I've made the changes you indicated. If you have any other suggestions/feedback for the background image file, feel free to follow up via email and let me know; ~~if you think it looks good now, I'll start annotating wikitext~~. Seppi333 (Insert 2¢) 19:23, 8 August 2018 (UTC)[reply]

I went ahead and added the annotations since I'd still be using the same approximate coordinates for an annotation regardless of whether I end up swapping one compound with another. The enzyme labels still need to be added; a few minor tweaks the the enzyme annotation coordinates will probably be necessary once that's done. Seppi333 (Insert 2¢) 22:18, 8 August 2018 (UTC)[reply]

BRENDA ligand entries for Homo sapiens

Listing what I find on catalyzing enzymes from a database search in this section. Seppi333 (Insert 2¢) 17:39, 10 August 2018 (UTC)[reply]

17β-Estradiol → Estrone

Comprehensive search with commentary on isoenzymes: [1]

EC 1.1.1.35 - [2]
EC 1.1.1.50 - [3]
EC 1.1.1.51 - [4]
EC 1.1.1.62 - [5]: indicates 17β-HSD2, 17β-HSD4, and 17β-HSD5 are involved in this reaction and 17β-HSD1 is the predominant mediator of the reverse reaction.
EC 1.1.1.239 - [6]
EC 1.1.1.357 - [7]

Estrone

Comprehensive search with commentary on isoenzymes: [8]

EC 1.1.1.62 - [9]: indicates 17β-HSD1 is the predominant mediator of Estrone → 17β-Estradiol.
EC 1.1.1.239 - [10]
EC 1.1.1.357 - [11]

Estrone sulfation:

EC 2.8.2.2 [12]
EC 2.8.2.4: "high activity by SULT1E1, low activity by phenol sulfotransferase SULT1A1, EC 2.8.2.1" (SULT1E1 = EST) - [13]

Estrone glucuronidation:

EC 2.4.1.17: "glucuronidated by UGT1A3 and HGT1A9" - [14]

Estrone 2-hydroxylation:

Nothing listed – look for pathway in a textbook or review

Estrone 4-hydroxylation:

Nothing listed – look for pathway in a textbook or review

Estrone 16α-hydroxylation:

Nothing listed – look for pathway in a textbook or review

Estrone sulfate

Desulfation:

EC 3.1.6.2 (STS / steroid sulfatase) - [15]

16α-Hydroxyestrone

→17-Epiestriol:

Nothing listed – look for pathway in a textbook or review

→Estriol:

Nothing listed – look for pathway in a textbook or review

→16-Epiestriol:

Nothing listed – look for pathway in a textbook or review

Human Metabolome Database entries on ligands with enzymatic reactions listed

Estradiol: [16]

17β-HSD1 (listed as gene: HSD17B1) [Catalyzed reactions link: [17]]
17β-HSD2 (listed as gene: HSD17B2) [Catalyzed reactions link: [18]]
17β-HSD6 (listed as gene: HSD17B6) [Catalyzed reactions link: [19]]
17β-HSD7 (listed as gene: HSD17B7) [Catalyzed reactions link: [20]]
17β-HSD8 (listed as gene: HSD17B8) [Catalyzed reactions link: [21]]
17β-HSD11 (listed as gene: HSD17B11) [Catalyzed reactions link: [22]]
17β-HSD12 (listed as gene: HSD17B12) [Catalyzed reactions link: [23]]

Estrone: [24]

CYP450:

CYP1A1
CYP1A2
CYP1B1
CYP2A7
CYP2A13
CYP2B6
CYP2C8
CYP2C9
CYP2C19
CYP2D6
CYP2E1
CYP2F1
CYP2J2
CYP2S1
CYP3A4
CYP4B1
CYP4Z1
CYP19A1C

... I think I'm just going to list "CYP450". Seppi333 (Insert 2¢) 18:32, 10 August 2018 (UTC)[reply]

@@ Line 66: / Line 66: @@
 == Human Metabolome Database entries on ligands with enzymatic reactions listed ==
-[http://www.hmdb.ca/metabolites/HMDB0000151 '''Estradiol''']: [http://www.hmdb.ca/metabolites/HMDB0000151/metabolite_protein_links]
+'''[http://www.hmdb.ca/metabolites/HMDB0000151 Estradiol]''': [http://www.hmdb.ca/metabolites/HMDB0000151/metabolite_protein_links]
-*17β-HSD2 (gene: HSD17B2) [Catalyzed reactions link: [http://www.hmdb.ca/proteins/HMDBP00447]]
+*17β-HSD1 (listed as gene: HSD17B1) [Catalyzed reactions link: [http://www.hmdb.ca/proteins/HMDBP00847]]
-*17β-HSD8 (listed as gene: HSD17B8) [Catalyzed reactions link: [http://www.hmdb.ca/proteins/HMDBP00453]]
+*17β-HSD2 (listed as gene: HSD17B2) [Catalyzed reactions link: [http://www.hmdb.ca/proteins/HMDBP00447]]
+*17β-HSD6 (listed as gene: HSD17B6) [Catalyzed reactions link: [http://www.hmdb.ca/proteins/HMDBP02862]]
 *17β-HSD7 (listed as gene: HSD17B7) [Catalyzed reactions link: [http://www.hmdb.ca/proteins/HMDBP00848]]
+*17β-HSD8 (listed as gene: HSD17B8) [Catalyzed reactions link: [http://www.hmdb.ca/proteins/HMDBP00453]]
+*17β-HSD11 (listed as gene: HSD17B11) [Catalyzed reactions link: [http://www.hmdb.ca/proteins/HMDBP00547]]
+*17β-HSD12 (listed as gene: HSD17B12) [Catalyzed reactions link: [http://www.hmdb.ca/proteins/HMDBP08861]]
-[http://www.hmdb.ca/metabolites/HMDB0000145 '''Estrone''']: [http://www.hmdb.ca/metabolites/HMDB0000145/metabolite_protein_links]
+'''[http://www.hmdb.ca/metabolites/HMDB0000145 Estrone]''': [http://www.hmdb.ca/metabolites/HMDB0000145/metabolite_protein_links]
 CYP450:
@@ Line 94: / Line 98: @@
 *CYP4Z1
 *CYP19A1C
+... I think I'm just going to list "CYP450". [[User:Seppi333|'''<span style="color:#32CD32;">Seppi</span>''<span style="color:Black;">333</span>''''']]&nbsp;([[User Talk:Seppi333|Insert&nbsp;'''2¢''']]) 18:32, 10 August 2018 (UTC)