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'''Research'''
'''Research'''

While she was still at Stanford University where she had received her PhD, in 1999 she published a paper on yeast genomics.<ref>{{Cite web|url=https://www.newscientist.com/article/mg16321994-500-behind-the-scenes/|title=Behind the Scenes|last=|first=|date=August 14, 1999|website=New Scientist|archive-url=|archive-date=|dead-url=|access-date=October 27, 2018}}</ref>


'''Contributions to science:'''
'''Contributions to science:'''

Revision as of 14:07, 27 October 2018

Elizabeth Ann Winzeler is a professor at the University of California, San Diego, School of Medicine and a microbiology researcher.[1] She is particularly noted for genomic level investigation of yeast and the malaria parasite and for development of new drugs to treat malaria more effectively. Winzeler has been elected to the American Academy of Microbiology in 2016[1] and received a Gates Foundation grant to pursue her design of anti-malarial drugs in

Early life and education

Elizabeth was born in Canton, Ohio to Robert Lee Winzeler and Judith Kay Winzeler on May 8, 1962. She had malaria when her family was in Malasia for her father's sabbatical leave, which may have put malaria on her mind early.[2]

Dr. Winzeler attended Lewis and Clark College in Portland, Oregon where she first intended to become an art major, but when she took physics with Professor of Physics Robert Deery during senior year she discovered she liked mathematics and was good at it.[2] She added a major in Natural Sciences and received her B.A. in Natural Sciences and Art in 1984.[2] After college, she learned to be a computer programmer by working at the Bureau of Labor Statistics in Washington, D.C.[2] She then returned to academia to receive her M.S. in Biophysics and Biochemistry in 1990 at Oregon State University in Corvallis, Oregon.[2] In 1996, she was awarded the Ph.D. from Stanford University in Stanford, California in Developmental Biology.[2]

Career

From 2007 to 2012, Winzeler headed the Department of Cellular Biology at the Genomics Institute of the Novartis Research Foundation.[2] From 2010 to 2012, she was also Associate Professor in the Department of Genetics and Department of Immunology & Microbial Science at Scripps Research Institute.[2] In 2012, she became Professor of Peidatrics at University of California, San Diego and Director of Translational Research at the UCSD Heath Sciences Center for Immunity, Infection, and Inflammation.[2]

Research

While she was still at Stanford University where she had received her PhD, in 1999 she published a paper on yeast genomics.[3]

Contributions to science:

  • Evidence-based annotation of the malaria parasite's genome using comparative expression profiling.[3]
  • The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification.[4]
  • In silico discovery of transcription regulatory elements in Plasmodium falciparum.[5]
  • Discovery of gene function by expression profiling of the malaria parasite life cycle.[6]
  • High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.[7]
  • KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.[8]
  • Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.[9]
  • In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.[10]
  • Diagana TT. Spiroindolones, a potent compound class for the treatment of malaria.[11]
  • Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.[12]
  • Targeting Plasmodium PI(4)K to eliminate malaria.[13]
  • Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials.[14]
  • Direct allelic variation scanning of the yeast genome.[15]
  • Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.[16]
  • Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays.[17]
  • Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin.[18]

Patents:

  • Method for Parallel Screening of Allelic Variation[19]
  • Compounds and Compositions as Kinase Inhibitors[20]

Awards and honors

  • The Ellison Medical Foundation[23] New Scholar Award (2001)
  • American Society of Tropical Medicine and Hygiene (ASTMH) Molecular, Cellular and Immuno Parasitology Award (2002)
  • W.M. Keck Foundation, Distinguished Young Scholar in Medical Research Award (2004)
  • Worm Free World[27] Board of Directors (2012-2013)
  • Scientific Advisory Board, Structural Drug Discovery Consortium (2013-present)
  • Bailey Ashford Medal[28] American Society of Tropical Medicine and Hygiene (2014)
  • Scientific Advisory Board, Tres Cantos Open Laboratory Foundation (2014-present)
  • Fellow of the American Society of Microbiology (2016)
  • Medicines for Malaria Venture Project of the Year[29] (2017)
  • Alice and C. C. Wang in Molecular Parasitology[30] (2018)
  • William Trager Award on behalf of ASTMH and the American Committee of Molecular, Cellular and Immunoparasitology[31] (2018)

References

·  American Academy in Microbiology: https://www.asm.org/index.php/aam

·  · Complete list of Dr. Winzeler's published work: https://www.ncbi.nlm.nih.gov/pubmed/?term=winzeler+e%2A

·  ·  Zhou, Y; Ramachandran, V; Kumar, K. A; Westenberger, S; Refour, P; Zhou, B; Li, F; Young, J. A; Chen, K; Plouffe, D; Henson, K; Nussenzweig, V; Carlton, J; Vinetz, J. M; Duraisingh, M. T; Winzeler, E. A (2008). "Evidence-based annotation of the malaria parasite's genome using comparative expression profiling". PLOS ONE. 3 (2): e1570. Bibcode:2008PLoSO...3.1570Z. doi:10.1371/journal.pone.0001570. PMC 2215772. PMID 18270564.

·  ·  Young, J. A; Fivelman, Q. L; Blair, P. L; de la Vega, P; Le Roch, K. G; Zhou, Y; Carucci, D. J; Baker, D. A; Winzeler, E. A (2005). "The Plasmodium falciparum sexual development transcriptome: A microarray analysis using ontology-based pattern identification" (PDF). Molecular and Biochemical Parasitology. 143 (1): 67–79. doi:10.1016/j.molbiopara.2005.05.007. PMID 16005087.

·  ·  Young, J. A; Johnson, J. R; Benner, C; Yan, S. F; Chen, K; Le Roch, K. G; Zhou, Y; Winzeler, E. A (2008). "In silico discovery of transcription regulatory elements in Plasmodium falciparum". Bmc Genomics. 9: 70. doi:10.1186/1471-2164-9-70. PMC 2268928. PMID 18257930.

·  ·  Le Roch, K. G; Zhou, Y; Blair, P. L; Grainger, M; Moch, J. K; Haynes, J. D; de la Vega, P; Holder, A. A; Batalov, S; Carucci, D. J; Winzeler, E. A (2003). "Discovery of gene function by expression profiling of the malaria parasite life cycle". Science. 301 (5639): 1503–8. Bibcode:2003Sci...301.1503L. doi:10.1126/science.1087025. PMID 12893887.

·  ·  Plouffe, D. M; Wree, M; Du, A. Y; Meister, S; Li, F; Patra, K; Lubar, A; Okitsu, S. L; Flannery, E. L; Kato, N; Tanaseichuk, O; Comer, E; Zhou, B; Kuhen, K; Zhou, Y; Leroy, D; Schreiber, S. L; Scherer, C. A; Vinetz, J; Winzeler, E. A (2016). "High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission". Cell Host & Microbe. 19 (1): 114–26. doi:10.1016/j.chom.2015.12.001. PMC 4723716. PMID 26749441.

·  ·  Kuhen, K. L; Chatterjee, A. K; Rottmann, M; Gagaring, K; Borboa, R; Buenviaje, J; Chen, Z; Francek, C; Wu, T; Nagle, A; Barnes, S. W; Plouffe, D; Lee, M. C; Fidock, D. A; Graumans, W; Van De Vegte-Bolmer, M; Van Gemert, G. J; Wirjanata, G; Sebayang, B; Marfurt, J; Russell, B; Suwanarusk, R; Price, R. N; Nosten, F; Tungtaeng, A; Gettayacamin, M; Sattabongkot, J; Taylor, J; Walker, J. R; et al. (2014). "KAF156 is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission". Antimicrobial Agents and Chemotherapy. 58 (9): 5060–5067. doi:10.1128/AAC.02727-13. PMC 4135840. PMID 24913172.

·  ·  Yeung, B. K; Zou, B; Rottmann, M; Lakshminarayana, S. B; Ang, S. H; Leong, S. Y; Tan, J; Wong, J; Keller-Maerki, S; Fischli, C; Goh, A; Schmitt, E. K; Krastel, P; Francotte, E; Kuhen, K; Plouffe, D; Henson, K; Wagner, T; Winzeler, E. A; Petersen, F; Brun, R; Dartois, V; Diagana, T. T; Keller, T. H (2010). "Spirotetrahydro beta-carbolines (spiroindolones): A new class of potent and orally efficacious compounds for the treatment of malaria". Journal of Medicinal Chemistry. 53 (14): 5155–64. doi:10.1021/jm100410f. PMID 20568778.

·  ·  Plouffe, D; Brinker, A; McNamara, C; Henson, K; Kato, N; Kuhen, K; Nagle, A; Adrián, F; Matzen, J. T; Anderson, P; Nam, T. G; Gray, N. S; Chatterjee, A; Janes, J; Yan, S. F; Trager, R; Caldwell, J. S; Schultz, P. G; Zhou, Y; Winzeler, E. A (2008). "In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen". Proceedings of the National Academy of Sciences. 105 (26): 9059–64. Bibcode:2008PNAS..105.9059P. doi:10.1073/pnas.0802982105. PMC 2440361. PMID 18579783.

·  ·  Rottmann, M; McNamara, C; Yeung, B. K; Lee, M. C; Zou, B; Russell, B; Seitz, P; Plouffe, D. M; Dharia, N. V; Tan, J; Cohen, S. B; Spencer, K. R; González-Páez, G. E; Lakshminarayana, S. B; Goh, A; Suwanarusk, R; Jegla, T; Schmitt, E. K; Beck, H. P; Brun, R; Nosten, F; Renia, L; Dartois, V; Keller, T. H; Fidock, D. A; Winzeler, E. A; Diagana, T. T (2010). "Spiroindolones, a potent compound class for the treatment of malaria". Science. 329 (5996): 1175–80. Bibcode:2010Sci...329.1175R. doi:10.1126/science.1193225. PMC 3050001. PMID 20813948.

·  ·  Meister, S; Plouffe, D. M; Kuhen, K. L; Bonamy, G. M; Wu, T; Barnes, S. W; Bopp, S. E; Borboa, R; Bright, A. T; Che, J; Cohen, S; Dharia, N. V; Gagaring, K; Gettayacamin, M; Gordon, P; Groessl, T; Kato, N; Lee, M. C; McNamara, C. W; Fidock, D. A; Nagle, A; Nam, T. G; Richmond, W; Roland, J; Rottmann, M; Zhou, B; Froissard, P; Glynne, R. J; Mazier, D; et al. (2011). "Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery". Science. 334 (6061): 1372–7. Bibcode:2011Sci...334.1372M. doi:10.1126/science.1211936. PMC 3473092. PMID 22096101.

·  ·  McNamara, C. W; Lee, M. C; Lim, C. S; Lim, S. H; Roland, J; Simon, O; Yeung, B. K; Chatterjee, A. K; McCormack, S. L; Manary, M. J; Zeeman, A. M; Dechering, K. J; Kumar, T. S; Henrich, P. P; Gagaring, K; Ibanez, M; Kato, N; Kuhen, K. L; Fischli, C; Nagle, A; Rottmann, M; Plouffe, D. M; Bursulaya, B; Meister, S; Rameh, L; Trappe, J; Haasen, D; Timmerman, M; Sauerwein, R. W; et al. (2013). "Targeting Plasmodium PI(4)K to eliminate malaria". Nature. 504 (7479): 248–253. Bibcode:2013Natur.504..248M. doi:10.1038/nature12782. PMC 3940870. PMID 24284631.

·  ·  Flannery, E. L; McNamara, C. W; Kim, S. W; Kato, T. S; Li, F; Teng, C. H; Gagaring, K; Manary, M. J; Barboa, R; Meister, S; Kuhen, K; Vinetz, J. M; Chatterjee, A. K; Winzeler, E. A (2015). "Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials". Acs Chemical Biology. 10 (2): 413–20. doi:10.1021/cb500616x. PMC 4340351. PMID 25322084.

·  ·  Winzeler, E. A; Richards, D. R; Conway, A. R; Goldstein, A. L; Kalman, S; McCullough, M. J; McCusker, J. H; Stevens, D. A; Wodicka, L; Lockhart, D. J; Davis, R. W (1998). "Direct allelic variation scanning of the yeast genome". Science. 281 (5380): 1194–7. Bibcode:1998Sci...281.1194W. doi:10.1126/science.281.5380.1194. PMID 9712584.

·  ·  Winzeler, E. A; Shoemaker, D. D; Astromoff, A; Liang, H; Anderson, K; Andre, B; Bangham, R; Benito, R; Boeke, J. D; Bussey, H; Chu, A. M; Connelly, C; Davis, K; Dietrich, F; Dow, S. W; El Bakkoury, M; Foury, F; Friend, S. H; Gentalen, E; Giaever, G; Hegemann, J. H; Jones, T; Laub, M; Liao, H; Liebundguth, N; Lockhart, D. J; Lucau-Danila, A; Lussier, M; m'Rabet, N; et al. (1999). "Functional characterization of the S. Cerevisiae genome by gene deletion and parallel analysis". Science. 285 (5429): 901–6. PMID 10436161.

·  ·  Winzeler, E. A; Castillo-Davis, C. I; Oshiro, G; Liang, D; Richards, D. R; Zhou, Y; Hartl, D. L (2003). "Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays". Genetics. 163 (1): 79–89. PMC 1462430. PMID 12586698.

·  ·  Hoepfner, D; McNamara, C. W; Lim, C. S; Studer, C; Riedl, R; Aust, T; McCormack, S. L; Plouffe, D. M; Meister, S; Schuierer, S; Plikat, U; Hartmann, N; Staedtler, F; Cotesta, S; Schmitt, E. K; Petersen, F; Supek, F; Glynne, R. J; Tallarico, J. A; Porter, J. A; Fishman, M. C; Bodenreider, C; Diagana, T. T; Movva, N. R; Winzeler, E. A (2012). "Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin". Cell Host & Microbe. 11 (6): 654–63. doi:10.1016/j.chom.2012.04.015. PMC 3391680. PMID 22704625.

·  ·  Method for Parallel Screening of Allelic Variation: https://patents.google.com/patent/CA2273616A1/de

·  · Compounds and Compositions as Kinase Inhibitors: https://patents.google.com/patent/CA2676138A1/hr

·  · National Science Foundation Fellowship: https://www.nsf.gov/

·  · National Science Foundation Frontiers of Science: https://www.nsf.gov/div/index.jsp?div=EF

·  ·  The Ellison Medical Foundation: http://www.ellisonfoundation.org/

·  ·  RECOMB: https://en.wikipedia.org/wiki/Research_in_Computational_Molecular_Biology

·  ·  Howard Hughes Medical Institute: https://www.hhmi.org/

·  ·  Howard T. Ricketts: https://htrl-sites.uchicago.edu/page/about

·  ·  Worm Free World: https://experiment.com/projects/wormfree-world-finding-new-cures

·  ·  Bailey Ashford Medal: http://www.astmh.org/awards-fellowships-medals/awards-and-honors/bailey-k-ashford-medal

·  · Medicines for Malaria Venture: https://www.mmv.org/research-development/project-year-award/mmv-project-year-award-2016

·  ·  Alice and C. C. Wang Award: http://www.asbmb.org/awards/wang/

31.   ·  William Trager Award: http://www.astmh.org/subgroups/acmcip#trager

External links

  • http://winzeler.ucsd.edu/
  • Elizabeth Winzeler at Science Magazine 2017
  • Elizabeth Winzeler at Science Magazine 1998

Category:Living people Category:1962 births Category:University of California, San Diego Category:Scripps Research Institute Category:Novartis Category:Stanford University alumni Category:Lewis & Clark College alumni Category:Oregon State University alumni Category:Malaria Category:Drug discovery Category:Genomics Category:Biochemistry Category:American women scientists Category:American Chemical Society Category:Bill & Melinda Gates Foundation

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  1. ^ a b "Elizabeth Ann Winzeler". American Society for Microbiology. Retrieved October 27, 2018. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  2. ^ a b c d e f g h i Valo, Ellisa (January 24, 2017). "Ending Malaria". Lewis and Clark College. Retrieved October 27, 2018. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  3. ^ "Behind the Scenes". New Scientist. August 14, 1999. Retrieved October 27, 2018. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
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