Gastrectomy: Difference between revisions
BrayLockBoy (talk | contribs) |
Inserted some numbers regarding the rates of post-operative complications from a meta-analysis |
||
| Line 25: | Line 25: | ||
Another major effect is the loss of the [[intrinsic factor|intrinsic-factor]]-secreting [[parietal cell]]s in the stomach lining. Intrinsic factor is essential for the uptake of [[Vitamin B12|vitamin B<sub>12</sub>]] in the [[terminal ileum]] and without it the patient will suffer from a [[vitamin B12 deficiency|vitamin B<sub>12</sub> deficiency]]. This can lead to a type of [[anemia|anaemia]] known as [[megaloblastic anaemia]] (can also be caused by [[folate deficiency]], or [[autoimmune disease]] where it is specifically known as [[pernicious anaemia]]) which severely reduces red-blood cell synthesis (known as [[erythropoiesis]], as well as other haemotological [[cell lineage]]s if severe enough but the red cell is the first to be affected). This can be treated by giving the patient direct injections of vitamin B<sub>12</sub>. [[Iron-deficiency anemia]] can occur as the stomach normally converts iron into its absorbable form.<ref>{{cite web|url=http://www.mystomachcancersymptoms.com/after-stomach-cancer-surgery.html|title=After Stomach Cancer Surgery - Complications : Diet|publisher=}}</ref> |
Another major effect is the loss of the [[intrinsic factor|intrinsic-factor]]-secreting [[parietal cell]]s in the stomach lining. Intrinsic factor is essential for the uptake of [[Vitamin B12|vitamin B<sub>12</sub>]] in the [[terminal ileum]] and without it the patient will suffer from a [[vitamin B12 deficiency|vitamin B<sub>12</sub> deficiency]]. This can lead to a type of [[anemia|anaemia]] known as [[megaloblastic anaemia]] (can also be caused by [[folate deficiency]], or [[autoimmune disease]] where it is specifically known as [[pernicious anaemia]]) which severely reduces red-blood cell synthesis (known as [[erythropoiesis]], as well as other haemotological [[cell lineage]]s if severe enough but the red cell is the first to be affected). This can be treated by giving the patient direct injections of vitamin B<sub>12</sub>. [[Iron-deficiency anemia]] can occur as the stomach normally converts iron into its absorbable form.<ref>{{cite web|url=http://www.mystomachcancersymptoms.com/after-stomach-cancer-surgery.html|title=After Stomach Cancer Surgery - Complications : Diet|publisher=}}</ref> |
||
Another side effect is the loss of [[ghrelin]] production, which has been shown to be compensated after a while.<ref>{{cite journal|author1=Masayasu Kojima|author2=Kenji Kangawa|title=Ghrelin: Structure and Function|journal=Physiol Rev |volume=85|issue=2|pp=495–522|year=2005|doi=10.1152/physrev.00012.2004|pmid=15788704|url=http://163.178.103.176/AIBC/Documentos/Referencia7_5_4.pdf}}</ref> |
Another side effect is the loss of [[ghrelin]] production, which has been shown to be compensated after a while.<ref>{{cite journal|author1=Masayasu Kojima|author2=Kenji Kangawa|title=Ghrelin: Structure and Function|journal=Physiol Rev |volume=85|issue=2|pp=495–522|year=2005|doi=10.1152/physrev.00012.2004|pmid=15788704|url=http://163.178.103.176/AIBC/Documentos/Referencia7_5_4.pdf}}</ref> Post-operatively, up to 70% of patients undergoing total gastrectomy develop complications such as dumping syndrome and reflux esophagitis.<ref name=":0">{{Cite journal|last=Syn|first=Nicholas L.|last2=Wee|first2=Ian|last3=Shabbir|first3=Asim|last4=Kim|first4=Guowei|last5=So|first5=Jimmy Bok-Yan|date=2018-10|title=Pouch Versus No Pouch Following Total gastrectomy|url=https://insights.ovid.com/crossref?an=00000658-900000000-95344|journal=Annals of Surgery|language=ENGLISH|volume=Publish Ahead of Print|pages=1|doi=10.1097/sla.0000000000003082|issn=0003-4932}}</ref> A meta-analysis of 25 studies found that construction of a "pouch", which serves as a "stomach substitute", reduced the incidence of dumping syndrome and reflux esophagitis by 73% and 63% respectively, and led to improvements in quality-of-life, nutritional outcomes, and body mass index.<ref name=":0" /> |
||
==History== |
==History== |
||
Revision as of 22:24, 11 November 2018
 | You can help expand this article with text translated from the corresponding article in Japanese. (July 2013) Click [show] for important translation instructions.
|
| Gastrectomy | |
|---|---|
 Diagram of the stomach, showing the different regions. | |
| ICD-9-CM | 43.5-43.9 |
| MeSH | D005743 |
| MedlinePlus | 002945 |
A gastrectomy is a partial or total surgical removal of the stomach.
Indications
Gastrectomies are performed to treat stomach cancer and perforations of the stomach wall.
In severe duodenal ulcers it may be necessary to remove the lower portion of the stomach called the pylorus and the upper portion of the small intestine called the duodenum. If there is a sufficient portion of the upper duodenum remaining a Billroth I procedure is performed, where the remaining portion of the stomach is reattached to the duodenum before the bile duct and the duct of the pancreas. If the stomach cannot be reattached to the duodenum a Billroth II is performed, where the remaining portion of the duodenum is sealed off, a hole is cut into the next section of the small intestine called the jejunum and the stomach is reattached at this hole. As the pylorus is used to grind food and slowly release the food into the small intestine, removal of the pylorus can cause food to move into the small intestine faster than normal, leading to gastric dumping syndrome.
Polya's operation
Also known as the Reichel–Polya operation, this is a type of posterior gastroenterostomy which is a modification of the Billroth II operation[1] developed by Eugen Pólya and Friedrich Paul Reichel. It involves a resection of 2/3 of the stomach with blind closure of the duodenal stump and a retrocolic gastro-jejunal anastomosis.
Post-operative effects
The most obvious effect of the removal of the stomach is the loss of a storage place for food while it is being digested. Since only a small amount of food can be allowed into the small intestine at a time, the patient will have to eat small amounts of food regularly in order to prevent gastric dumping syndrome.
Another major effect is the loss of the intrinsic-factor-secreting parietal cells in the stomach lining. Intrinsic factor is essential for the uptake of vitamin B12 in the terminal ileum and without it the patient will suffer from a vitamin B12 deficiency. This can lead to a type of anaemia known as megaloblastic anaemia (can also be caused by folate deficiency, or autoimmune disease where it is specifically known as pernicious anaemia) which severely reduces red-blood cell synthesis (known as erythropoiesis, as well as other haemotological cell lineages if severe enough but the red cell is the first to be affected). This can be treated by giving the patient direct injections of vitamin B12. Iron-deficiency anemia can occur as the stomach normally converts iron into its absorbable form.[2]
Another side effect is the loss of ghrelin production, which has been shown to be compensated after a while.[3] Post-operatively, up to 70% of patients undergoing total gastrectomy develop complications such as dumping syndrome and reflux esophagitis.[4] A meta-analysis of 25 studies found that construction of a "pouch", which serves as a "stomach substitute", reduced the incidence of dumping syndrome and reflux esophagitis by 73% and 63% respectively, and led to improvements in quality-of-life, nutritional outcomes, and body mass index.[4]
History
The first successful gastrectomy was performed by Theodor Billroth in 1881 for cancer of the stomach.
Historically, gastrectomies were used to treat peptic ulcers.[5] These are now usually treated with antibiotics, as it was recognized that they are usually due to Helicobacter pylori infection or chemical imbalances in the gastric juices.
In the past a gastrectomy for peptic ulcer disease was often accompanied by a vagotomy, to reduce acid production. This problem is now managed with proton pump inhibitors.
See also
References
- ^ Lahey Clinic (1941). Surgical Practice of the Lahey Clinic, Boston, Massachusetts. W.B. Saunders company. p. 217. Retrieved 2008-07-18.
- ^ "After Stomach Cancer Surgery - Complications : Diet".
- ^ Masayasu Kojima; Kenji Kangawa (2005). "Ghrelin: Structure and Function" (PDF). Physiol Rev. 85 (2): 495–522. doi:10.1152/physrev.00012.2004. PMID 15788704.
- ^ a b Syn, Nicholas L.; Wee, Ian; Shabbir, Asim; Kim, Guowei; So, Jimmy Bok-Yan (2018-10). "Pouch Versus No Pouch Following Total gastrectomy". Annals of Surgery. Publish Ahead of Print: 1. doi:10.1097/sla.0000000000003082. ISSN 0003-4932.
{{cite journal}}: Check date values in:|date=(help) - ^ E. Pólya:Zur Stumpfversorgung nach Magenresektion. Zentralblatt für Chirurgie, Leipzig, 1911, 38: 892-894.
