Benperidol: Difference between revisions
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'''Benperidol''', sold under the trade name '''Anquil''' among others, is a drug which is a highly potent [[butyrophenone]] derivative. It is the most potent neuroleptic on the European market, with [[chlorpromazine]] equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to [[haloperidol]]).<ref>Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; {{ISBN|3-8047-1773-X}} (in German)</ref> It is an [[antipsychotic]], which can be used for the treatment of [[schizophrenia]],<ref>Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.</ref> but it is primarily used to control [[Anti-social behaviour|antisocial]] [[hypersexual]] behaviour,<ref>British National Formulary (49th), British Medical Association 2005 p 183</ref> and is sometimes prescribed to [[sex offender]]s as a condition of their [[parole]], as an alternative to anti-[[androgen]] drugs such as [[cyproterone acetate]].<ref>Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.</ref> |
'''Benperidol''', sold under the trade name '''Anquil'''<ref>{{Cite journal|last=|first=|date=1974-02-01|title=Benperidol - a drug for sexual offenders?|url=|journal=Drug and Therapeutics Bulletin|publisher=BMJ Publishing Group Ltd|volume=12|pages=12|via=}}</ref> among others, is a drug which is a highly potent [[butyrophenone]] derivative. It is the most potent neuroleptic on the European market, with [[chlorpromazine]] equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to [[haloperidol]]).<ref>Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; {{ISBN|3-8047-1773-X}} (in German)</ref> It is an [[antipsychotic]], which can be used for the treatment of [[schizophrenia]],<ref>Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.</ref> but it is primarily used to control [[Anti-social behaviour|antisocial]] [[hypersexual]] behaviour,<ref>British National Formulary (49th), British Medical Association 2005 p 183</ref> and is sometimes prescribed to [[sex offender]]s as a condition of their [[parole]], as an alternative to anti-[[androgen]] drugs such as [[cyproterone acetate]].<ref>Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.</ref> |
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Benperidol was discovered at [[Janssen Pharmaceutica]] in 1961. |
Benperidol was discovered at [[Janssen Pharmaceutica]] in 1961. |
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Revision as of 15:50, 19 December 2018
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| Clinical data | |
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| Trade names | Anquil |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status |
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| Identifiers | |
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| CAS Number | |
| PubChem CID | |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.016.521 |
| Chemical and physical data | |
| Formula | C22H24FN3O2 |
| Molar mass | 381.443 g/mol g·mol−1 |
| 3D model (JSmol) | |
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Benperidol, sold under the trade name Anquil[1] among others, is a drug which is a highly potent butyrophenone derivative. It is the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol).[2] It is an antipsychotic, which can be used for the treatment of schizophrenia,[3] but it is primarily used to control antisocial hypersexual behaviour,[4] and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone acetate.[5]
Benperidol was discovered at Janssen Pharmaceutica in 1961.
Synthesis
See also
- Timiperone has the same structure but thiourea instead of normal urea.
- Pimozide & Oxiperomide & Neflumozide are also made from 4-(1-Benzimidazolinone)piperidine prec.
- Droperidol is self-same albeit with a tetrahydropyridine ring.
References
- ^ "Benperidol - a drug for sexual offenders?". Drug and Therapeutics Bulletin. 12. BMJ Publishing Group Ltd: 12. 1974-02-01.
- ^ Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)
- ^ Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.
- ^ British National Formulary (49th), British Medical Association 2005 p 183
- ^ Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.
- ^ BE 626307 (1963 to Janssen), C.A. 60, 10690c (1964), corresp. to GB 989755.
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