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'''Mean platelet volume''' ('''MPV''') is a machine-calculated measurement of the average size of [[platelets]] found in [[blood]] and is typically included in [[blood tests]] as part of the [[Complete blood count|CBC]]. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in [[bone marrow]] or platelet destruction problems.<ref name="LabTestsOnline">[http://www.labtestsonline.org/understanding/analytes/cbc/test.html], Lab Tests Online.</ref>
'''Mean platelet volume''' ('''MPV''') is a machine-calculated measurement of the average size of [[platelets]] found in [[blood]] and is typically included in [[blood tests]] as part of the [[Complete blood count|CBC]]. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in [[bone marrow]] or platelet destruction problems.<ref name="LabTestsOnline">[http://www.labtestsonline.org/understanding/analytes/cbc/test.html], Lab Tests Online.</ref>


MPV is higher when there is destruction of platelets. This may be seen in [[inflammatory bowel disease]],<ref>{{cite journal|last=Liu|first=S|author2=Ren, J |author3=Han, G |author4=Wang, G |author5=Gu, G |author6=Xia, Q |author7= Li, J |title=Mean platelet volume: a controversial marker of disease activity in Crohn's disease.|journal=European Journal of Medical Research|date=Oct 12, 2012|volume=17|pages=27|pmid=23058104|doi=10.1186/2047-783x-17-27 |pmc=3519557}}</ref> [[immune thrombocytopenic purpura]] (ITP), [[myeloproliferative disease]]s and [[Bernard-Soulier syndrome]]. It may also be related to [[pre-eclampsia]], and recovery from transient [[hypoplasia]].<ref name="Arch Pathol Lab Med. Vol 133, September 2009;1441-43.">[https://docs.google.com/viewer?a=v&q=cache:WD-fbfqdadUJ:www.metromedlab.com/SiteContent/Documents/File/IPN%2520MPV%2520%2520101609.pdf+%22mean+platelet+volume%22&hl=en&gl=us&pid=bl&srcid=ADGEESjXgOqNk6-jITg3Rn_c64mK0iSxOTrt5I6VycZ4yzlEf3z1ycjsY_1nU1H8hiYmppb3QKniYikKEIXM0CDCnwSvavxsO9wmKvgM2778hWm2McGaIv0Dz0GJzND39M3h3G29wxdw&sig=AHIEtbSsN2L1cvMZLM4tJ5snc9_uaKIADQ&pli=1], Arch Pathol Lab Med. Vol 133, September 2009;1441-43..</ref>
MPV is higher when there is destruction of platelets. This may be seen in [[inflammatory bowel disease]],<ref>{{cite journal|last=Liu|first=S|author2=Ren, J |author3=Han, G |author4=Wang, G |author5=Gu, G |author6=Xia, Q |author7= Li, J |title=Mean platelet volume: a controversial marker of disease activity in Crohn's disease.|journal=European Journal of Medical Research|date=Oct 12, 2012|volume=17|pages=27|pmid=23058104|doi=10.1186/2047-783x-17-27 |pmc=3519557}}</ref> [[immune thrombocytopenic purpura]] (ITP), [[myeloproliferative disease]]s and [[Bernard-Soulier syndrome]]. It may also be related to [[pre-eclampsia]] and recovery from transient [[hypoplasia]].<ref name="Arch Pathol Lab Med. Vol 133, September 2009;1441-43.">[https://docs.google.com/viewer?a=v&q=cache:WD-fbfqdadUJ:www.metromedlab.com/SiteContent/Documents/File/IPN%2520MPV%2520%2520101609.pdf+%22mean+platelet+volume%22&hl=en&gl=us&pid=bl&srcid=ADGEESjXgOqNk6-jITg3Rn_c64mK0iSxOTrt5I6VycZ4yzlEf3z1ycjsY_1nU1H8hiYmppb3QKniYikKEIXM0CDCnwSvavxsO9wmKvgM2778hWm2McGaIv0Dz0GJzND39M3h3G29wxdw&sig=AHIEtbSsN2L1cvMZLM4tJ5snc9_uaKIADQ&pli=1], Arch Pathol Lab Med. Vol 133, September 2009;1441-43..</ref>


Abnormally low MPV values correlate with [[thrombocytopenia]] when it is due to impaired production as in [[aplastic anemia]]. In addition, low MPV can correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as [[Wiskott-Aldrich Syndrome]] (WAS),<ref>{{cite web|url=http://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/wiskott-aldrich-syndrome|website=Immune Deficiency Foundation}}</ref> caused by a genetic mutation of the WAS gene.
Abnormally low MPV values correlate with [[thrombocytopenia]] when it is due to impaired production as in [[aplastic anemia]]. In addition, low MPV can correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as [[Wiskott-Aldrich Syndrome]] (WAS),<ref>{{cite web|url=http://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/wiskott-aldrich-syndrome|website=Immune Deficiency Foundation}}</ref> caused by a genetic mutation of the WAS gene.

Revision as of 21:16, 8 January 2019

Mean platelet volume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems.[1]

MPV is higher when there is destruction of platelets. This may be seen in inflammatory bowel disease,[2] immune thrombocytopenic purpura (ITP), myeloproliferative diseases and Bernard-Soulier syndrome. It may also be related to pre-eclampsia and recovery from transient hypoplasia.[3]

Abnormally low MPV values correlate with thrombocytopenia when it is due to impaired production as in aplastic anemia. In addition, low MPV can correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as Wiskott-Aldrich Syndrome (WAS),[4] caused by a genetic mutation of the WAS gene.

Sample for MPV testing is obtained in a Lavender-Top EDTA tube. A typical range of platelet volumes is 9.4–12.3 fL[5] (femtolitre), equivalent to spheres 2.65 to 2.9 µm in diameter.

Conditions associated with altered MPV

Decreased MPV

Increased MPV

Inherited Thrombocytopenia with Normal MPV

References

  1. ^ [1], Lab Tests Online.
  2. ^ Liu, S; Ren, J; Han, G; Wang, G; Gu, G; Xia, Q; Li, J (Oct 12, 2012). "Mean platelet volume: a controversial marker of disease activity in Crohn's disease". European Journal of Medical Research. 17: 27. doi:10.1186/2047-783x-17-27. PMC 3519557. PMID 23058104.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  3. ^ [2], Arch Pathol Lab Med. Vol 133, September 2009;1441-43..
  4. ^ Immune Deficiency Foundation http://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/wiskott-aldrich-syndrome. {{cite web}}: Missing or empty |title= (help)
  5. ^ "CBC (Complete Blood Count), Blood". www.healthcare.uiowa.edu. Retrieved 2018-02-22.
  6. ^ "Bernard-Soulier Syndrome Workup: Approach Considerations". emedicine.staging.medscape.com. Retrieved 2018-02-22.
  7. ^ McClatchey, Kenneth D. (2002). Clinical Laboratory Medicine. Lippincott Williams & Wilkins. ISBN 9780683307511.
  • [3] Immune Deficiency Foundation entry for Wiskott-Aldrich Syndrome
  • MPV Definition
  • [4] Medicinenet.com: Thrombocytopenia
  • [5] Diabetesexplained.com: MPV
  • [6] ahajournals.org: Article related to MPV
  • Bessman, JD; Gilmer, PR; Gardner, FH. "Use of mean platelet volume improves detection of platelet disorders". Blood Cells. 11: 127–35. PMID 4074887.
  • [7] Wisegeekcom: What is Mean Platelet Volume
  • [8] Clinlabnavigator.com: MPV


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