Chlorphenesin carbamate: Difference between revisions
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Chlorophenesin carbamate (drug) <ref>https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+3031</ref> not to be confused with chlorophensin the preservative on EU Annex V/50.<ref>https://www.cir-safety.org/sites/default/files/Chlorp092012rep.pdf</ref> Tag: references removed |
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==Safety== |
==Safety== |
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The major adverse effect from this preservative on skin is [[allergy|allergic contact sensitivity]].<ref>{{cite journal |doi=10.1111/j.1600-0536.1981.tb04601.x |journal=Contact Dermatitis |year=1981 |volume=7 |issue=3 |pages=162 |title=Chlorphenesin sensitivity |author=Brown R |pmid=6456118}}</ref><ref>{{cite journal |doi=10.1111/j.1600-0536.1986.tb01234.x |journal=Contact Dermatitis |year=1986 |volume=14 |issue=33 |pages=246 |title=Allergic contact sensitivity to chlorphenesin |author=Burns DA |pmid=2941223 }}</ref> Systemic intoxication from [[transdermal]] use has not been observed, although the FDA discourages its use as an ingredient in nipple cream for nursing mothers.<ref>{{Cite web| url=http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2008/ucm116900.htm |title = FDA Warns Consumers Against Using Mommy's Bliss Nipple Cream Product can be harmful to nursing infants}}</ref> |
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==References== |
==References== |
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{{reflist}} |
{{reflist}} |
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{{Antifungals}} |
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{{Muscle relaxants}} |
{{Muscle relaxants}} |
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[[Category:Muscle relaxants]] |
[[Category:Muscle relaxants]] |
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Revision as of 19:55, 15 January 2019
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| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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| Pharmacokinetic data | |
| Excretion | urine |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.002.902 |
| Chemical and physical data | |
| Formula | C10H12ClNO4 |
| Molar mass | 245.660 g/mol g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 86 to 92 °C (187 to 198 °F) |
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Chlorphenesin carbamate (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms.[1][2] Chlorphenesin is no longer used for this purpose in most developed nations due to the availability of much safer spasmolytics such as benzodiazepines.
Other central effects include sedation, anxiolysis, and dizziness. It also has antifungal and some antibacterial properties and is thus classified as an antifungal for topical use by the WHO.[3]
Safety
References
- ^ Okuyama, S; Aihara, H (1987). "Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats". Research communications in chemical pathology and pharmacology. 55 (2): 147–60. PMID 3823606.
- ^ Kurachi, M; Aihara, H (1984). "Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats". Japanese journal of pharmacology. 36 (1): 7–13. doi:10.1254/jjp.36.7. PMID 6503049.
- ^ ATC code D01AE07