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'''Linda Randall''' is a Professor Emerita of Biochemistry and Wurdack Chair Emerita of Biological Chemistry at University of Missouri.<ref name=":0">{{Cite web|url=https://biochem.missouri.edu/faculty/faculty-members/randalll/index.php|title=Linda Randall|last=|first=|date=|website=University of Missouri|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref> Her research has shown unexpected and complex details of the movement of newly made proteins from the cytosol across membranes into organelles of the cell.  In particular, she found that the entire protein was kept unfolded by association with a chaperone and not just directed to cross membranes by its terminal leader sequence.<ref name=":1">{{Cite web|url=http://www.nasonline.org/member-directory/members/3003916.html|title=Linda Randall|last=|first=|date=|website=National Academy of Sciences|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref> In 1997, she was elected to the National Academy of Sciences of the USA because of the excellence of this work.  She has received a number of other honors and awards.<ref name=":1" />
'''Linda Randall''' is a Professor Emerita of Biochemistry and Wurdack Chair Emerita of Biological Chemistry at the [[University of Missouri]].<ref name=":0">{{Cite web|url=https://biochem.missouri.edu/faculty/faculty-members/randalll/index.php|title=Linda Randall|last=|first=|date=|website=University of Missouri|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref> Her research has shown unexpected and complex details of the movement of newly made proteins from the [[cytosol]] across membranes into the organelles of the cell.  In particular, she found that the entire protein was kept unfolded by association with a chaperone and not just directed to cross membranes by its terminal leader sequence.<ref name=":1">{{Cite web|url=http://www.nasonline.org/member-directory/members/3003916.html|title=Linda Randall|last=|first=|date=|website=National Academy of Sciences|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref> In 1997, she was elected to the National Academy of Sciences of the USA because of the excellence of this work.  She has received a number of other honors and awards.<ref name=":1" />


== Education ==
== Education ==
Linda Randall received the BS at Colorado State University in Zoology and the PhD at University of Wisconsin in Molecular Biology.<ref name=":0" />
Randall received the BS at [[Colorado State University]] in Zoology and the PhD at the [[University of Wisconsin]] in Molecular Biology.<ref name=":0" />


== Academic research career ==
== Academic research career ==
Linda Randall was a professor at University of Uppsala for eight years before joining the faculty at Washington State University in 1981.<ref>{{Cite web|url=https://s3.wp.wsu.edu/uploads/sites/9/2016/09/WSUchemNewsletter-Summer1997ocr.pdf|title=Biochemists Elected to the National Academy of Sciences|last=|first=|date=1997|website=Washington State University Biochemistry Department|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref> After twenty years at WSU, she moved to University of Missouri.<ref name=":2">{{Cite web|url=https://lmtribune.com/education/departing-profs-have-harsh-words-for-wsu-research-team-leaders/article_d030c0b4-dfc8-58ed-8e9b-7a5829f4f839.html|title=Departing Professors Have Harsh Words for WSU|last=Smith|first=Debra|date=September 22, 2000|website=The Lewiston Tribune|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref>
Randall was a professor at the [[University of Uppsala]] for eight years before joining the faculty at [[Washington State University]], WSU, in 1981.<ref>{{Cite web|url=https://s3.wp.wsu.edu/uploads/sites/9/2016/09/WSUchemNewsletter-Summer1997ocr.pdf|title=Biochemists Elected to the National Academy of Sciences|last=|first=|date=1997|website=Washington State University Biochemistry Department|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref> After twenty years at WSU, she moved to THE University of Missouri.<ref name=":2">{{Cite web|url=https://lmtribune.com/education/departing-profs-have-harsh-words-for-wsu-research-team-leaders/article_d030c0b4-dfc8-58ed-8e9b-7a5829f4f839.html|title=Departing Professors Have Harsh Words for WSU|last=Smith|first=Debra|date=September 22, 2000|website=The Lewiston Tribune|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref>


Randall's research focuses on mechanism of protein export in the bacterium ''Escherichia coli''.<ref name=":3">{{Cite web|url=https://biochem.missouri.edu/faculty/faculty-members/randalll/index.php|title=Linda Randall|last=|first=|date=|website=University of Missouri Biochemistry Department|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref> Her laboratory demonstrated the role of chaperones in transport and folding of proteins.<ref name=":1" /> <ref name=":3" />
Randall's research focuses on THE mechanism of protein export in the bacterium ''[[Escherichia coli]]''.<ref name=":3">{{Cite web|url=https://biochem.missouri.edu/faculty/faculty-members/randalll/index.php|title=Linda Randall|last=|first=|date=|website=University of Missouri Biochemistry Department|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref> Her laboratory demonstrated the role of chaperones in THE transport and folding of proteins.<ref name=":1" /> <ref name=":3" />


== Honors and awards ==
== Honors and awards ==
*National Academy of Sciences, 1997<ref name=":1" />
*National Academy of Sciences, 1997<ref name=":1" />
*American Academy of Microbiology<ref name=":3" />
*[[American Academy of Microbiology]]<ref name=":3" />
*American Academy of Arts and Sciences, 1984<ref>{{Cite web|url=https://www.amacad.org/content/news/pressReleases.aspx?pr=59
*[[American Academy of Arts and Sciences]], 1984<ref>{{Cite web|url=https://www.amacad.org/content/news/pressReleases.aspx?pr=59
American Academy Announces 2004 Fellows and Foreign Honorary Members
American Academy Announces 2004 Fellows and Foreign Honorary Members
4/30/2004|title=American Academy of Arts and Sciences Announces 2004 Fellows and Foreign Hnorary Members|last=|first=|date=April 30, 2004|website=|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref>
4/30/2004|title=American Academy of Arts and Sciences Announces 2004 Fellows and Foreign Hnorary Members|last=|first=|date=April 30, 2004|website=|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref>
*Fellow of American Association for the Advancement of Science<ref name=":3" />
*Fellow of the [[American Association for the Advancement of Science]]<ref name=":3" />
*Eli Lilly Award in Microbiology or Immunology (American Society for Microbiology)<ref>{{Cite web|url=https://www.asm.org/index.php/component/content/article/140-awards-a-grants/past-laureates/7791-eli-lilly-and-company-elanco-research-award-past-laureates|title=Eli Lilly and Company Elanco Research Award Past Laureates|last=|first=|date=|website=American Society for Microbiology|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref>
*Eli Lilly Award in Microbiology or Immunology ([[American Society for Microbiology]])<ref>{{Cite web|url=https://www.asm.org/index.php/component/content/article/140-awards-a-grants/past-laureates/7791-eli-lilly-and-company-elanco-research-award-past-laureates|title=Eli Lilly and Company Elanco Research Award Past Laureates|last=|first=|date=|website=American Society for Microbiology|archive-url=|archive-date=|dead-url=|access-date=December 4, 2018}}</ref>


== Selected Works ==
== Selected Works ==
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[[Category:Living people]]
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[[Category:American biochemists]]
[[Category:Women scientists]]
[[Category:Women scientists]]

Revision as of 12:41, 24 January 2019

Linda Randall is a Professor Emerita of Biochemistry and Wurdack Chair Emerita of Biological Chemistry at the University of Missouri.[1] Her research has shown unexpected and complex details of the movement of newly made proteins from the cytosol across membranes into the organelles of the cell.  In particular, she found that the entire protein was kept unfolded by association with a chaperone and not just directed to cross membranes by its terminal leader sequence.[2] In 1997, she was elected to the National Academy of Sciences of the USA because of the excellence of this work.  She has received a number of other honors and awards.[2]

Education

Randall received the BS at Colorado State University in Zoology and the PhD at the University of Wisconsin in Molecular Biology.[1]

Academic research career

Randall was a professor at the University of Uppsala for eight years before joining the faculty at Washington State University, WSU, in 1981.[3] After twenty years at WSU, she moved to THE University of Missouri.[4]

Randall's research focuses on THE mechanism of protein export in the bacterium Escherichia coli.[5] Her laboratory demonstrated the role of chaperones in THE transport and folding of proteins.[2] [5]

Honors and awards

Selected Works

  • Bariya P, Randall LL. (2018). “Co-assembly of SecYEG and SecA fully restores the properties of the native translocon.” J Bacteriol. 2018 Oct 1. doi: 10.1128 JB.00493-18 Epub ahead of print.
  • Findik BT, Smith VF, Randall LL. (2018). “Penetration into membrane of amino-terminal region of SecA when associated with SecYEG in active complexes.” Protein Sci. 27(3):681-691. doi: 10.1002/pro.3362.  
  • Suo Y, Hardy SJS, Randall LL. (2015). “The basis of asymmetry in the SecA:SecB complex.” J Mol Biol. 427(4):887-900. doi: 10.1016/j.jmb.2014.12.008. [PubMed]
  • Mao C, Cheadle CE, Hardy SJ, Lilly AA, Suo Y, Sanganna Gari RR, King GM, Randall LL. (2013). “Stoichiometry of SecYEG in the active translocase of Escherichia coli varies with precursor species.” Proc Natl Acad Sci U S A. 110(29):11815-20. doi: 10.1073/pnas.1303289110. [PubMed]
  • Sanganna Gari RR, Frey NC, Mao C, Randall LL, King GM. (2013). “Dynamic structure of the translocon SecYEG in membrane: direct single molecule observations.” J Biol Chem. 288(23):16848-54. doi: 10.1074/jbc.M113.471870. [PubMed]
  • Suo Y, Hardy SJ, Randall LL. (2011). “Orientation of SecA and SecB in complex, derived from disulfide cross-linking.” J Bacteriol. 193(1):190-6. doi: 10.1128/JB.00975-10. [PubMed]
  • Randall LL, Henzl MT. (2010). “Direct identification of the site of binding on the chaperone SecB for the amino terminus of the translocon motor SecA.” Protein Sci. 19(6):1173-9. doi: 10.1002/pro.392. [PubMed]
  • Crane JM, Lilly AA, Randall LL. (2010).  “Characterization of interactions between proteins using site-directed spin labeling and electron paramagnetic resonance spectroscopy.” Methods Mol Biol. 619:173-90. doi: 10.1007/978-1-60327-412-8_11. [PubMed]
  • Lilly AA, Crane JM, Randall LL. (2009). “Export chaperone SecB uses one surface of interaction for diverse unfolded polypeptide ligands.” Protein Sci. 18(9):1860-8. doi: 10.1002/pro.197. [PubMed]
  • Randall, L.L. and Hardy, S.J.S.  (1995) “High selectivity with low specificity: how SecB has solved the paradox of chaperone binding.”  Trends in Biochem Sci 20:65-69. DOI:https://doi.org/10.1016/S0968-0004(00)88959-8

References

  1. ^ a b "Linda Randall". University of Missouri. Retrieved December 4, 2018. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  2. ^ a b c d "Linda Randall". National Academy of Sciences. Retrieved December 4, 2018. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  3. ^ "Biochemists Elected to the National Academy of Sciences" (PDF). Washington State University Biochemistry Department. 1997. Retrieved December 4, 2018. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  4. ^ Smith, Debra (September 22, 2000). "Departing Professors Have Harsh Words for WSU". The Lewiston Tribune. Retrieved December 4, 2018. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  5. ^ a b c d "Linda Randall". University of Missouri Biochemistry Department. Retrieved December 4, 2018. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  6. ^ [https://www.amacad.org/content/news/pressReleases.aspx?pr=59 American Academy Announces 2004 Fellows and Foreign Honorary Members 4/30/2004 "American Academy of Arts and Sciences Announces 2004 Fellows and Foreign Hnorary Members"]. April 30, 2004. Retrieved December 4, 2018. {{cite web}}: Check |url= value (help); Cite has empty unknown parameter: |dead-url= (help); line feed character in |url= at position 61 (help)
  7. ^ "Eli Lilly and Company Elanco Research Award Past Laureates". American Society for Microbiology. Retrieved December 4, 2018. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
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