Borna disease: Difference between revisions
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'''Borna disease''' is an infectious [[neurological]] syndrome<ref name="pmid17522214">{{cite journal |vauthors=Ackermann A, Staeheli P, Schneider U |title=Adaptation of Borna disease virus to new host species attributed to altered regulation of viral polymerase activity |journal=J. Virol. |volume=81 |issue=15 |pages=7933–40 |date=August 2007 |pmid=17522214 |pmc=1951315 |doi=10.1128/JVI.00334-07 |
'''Borna disease''' is an infectious [[neurological]] syndrome<ref name="pmid17522214">{{cite journal |vauthors=Ackermann A, Staeheli P, Schneider U |title=Adaptation of Borna disease virus to new host species attributed to altered regulation of viral polymerase activity |journal=J. Virol. |volume=81 |issue=15 |pages=7933–40 |date=August 2007 |pmid=17522214 |pmc=1951315 |doi=10.1128/JVI.00334-07 }}</ref> of [[warm-blooded]] animals, caused by [[Bornaviridae|Borna disease viruses 1 and 2]] (BoDV-1/2), both of which are members of the species ''Mammalian 1 orthobornavirus''. BoDV-1 and 2 cause abnormal behaviour and fatality. Borna disease viruses 1 and 2 are [[neurotropic]] [[virus]]es and members of the ''[[Bornaviridae]]'' family within the ''[[Mononegavirales]]'' order. |
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Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in [[horse]]s and other animals, they are also controversially discussed as human infectious agents and therefore as potential [[zoonosis|zoonotic]] agents. The role of BoDV-1 and -2 in human illness is controversial and it is yet to be established whether BoDV-1 or -2 cause any overt disease in humans. However, correlative evidence exists linking BoDV-1/2 infection with neuropsychiatric disorders such as [[bipolar disorder]].<ref>{{cite web |url=http://articles.cnn.com/1998-08-31/health/9808_31_depression.virus_1_virus-depression-horses?_s=PM:HEALTH |publisher=CNN Health |author="(Quoted) Liv Bode - Robert Koch Institute, Ron Ferszt - Free University of Berlin" |title=Research suggests virus may play role in depression |date=August 31, 1998 |deadurl=yes |archiveurl=https://web.archive.org/web/20120303203415/http://articles.cnn.com/1998-08-31/health/9808_31_depression.virus_1_virus-depression-horses?_s=PM%3AHEALTH |archivedate=March 3, 2012 |df= }}</ref> |
Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in [[horse]]s and other animals, they are also controversially discussed as human infectious agents and therefore as potential [[zoonosis|zoonotic]] agents. The role of BoDV-1 and -2 in human illness is controversial and it is yet to be established whether BoDV-1 or -2 cause any overt disease in humans. However, correlative evidence exists linking BoDV-1/2 infection with neuropsychiatric disorders such as [[bipolar disorder]].<ref>{{cite web |url=http://articles.cnn.com/1998-08-31/health/9808_31_depression.virus_1_virus-depression-horses?_s=PM:HEALTH |publisher=CNN Health |author="(Quoted) Liv Bode - Robert Koch Institute, Ron Ferszt - Free University of Berlin" |title=Research suggests virus may play role in depression |date=August 31, 1998 |deadurl=yes |archiveurl=https://web.archive.org/web/20120303203415/http://articles.cnn.com/1998-08-31/health/9808_31_depression.virus_1_virus-depression-horses?_s=PM%3AHEALTH |archivedate=March 3, 2012 |df= }}</ref> |
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Experimental infection of [[rat]]s has been demonstrated to lead to learning impairments and altered social behaviour. The virus appears to be distributed primarily in the [[limbic system]] of the brain, including the [[hippocampus]] and [[entorhinal cortex]]. These areas of the brain are considered to be of importance in [[emotion]]. |
Experimental infection of [[rat]]s has been demonstrated to lead to learning impairments and altered social behaviour. The virus appears to be distributed primarily in the [[limbic system]] of the brain, including the [[hippocampus]] and [[entorhinal cortex]]. These areas of the brain are considered to be of importance in [[emotion]]. |
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Originally identified in [[sheep]] and [[horse]]s<ref name="pmid11944803">{{cite journal |vauthors=Dauphin G, Legay V, Pitel PH, Zientara S |title=Borna disease: current knowledge and virus detection in France |journal=Vet. Res. |volume=33 |issue=2 |pages=127–38 |year=2002 |pmid=11944803 |doi=10.1051/vetres:2002002 |
Originally identified in [[sheep]] and [[horse]]s<ref name="pmid11944803">{{cite journal |vauthors=Dauphin G, Legay V, Pitel PH, Zientara S |title=Borna disease: current knowledge and virus detection in France |journal=Vet. Res. |volume=33 |issue=2 |pages=127–38 |year=2002 |pmid=11944803 |doi=10.1051/vetres:2002002 }}</ref> in [[Europe]], it has since been found to occur in a wide range of warm-blooded animals including [[bird]]s, [[cattle]], [[cat]]s<ref name="pmid16841569">{{cite journal |vauthors=Kamhieh S, Flower RL |title=Borna disease virus (BDV) infection in cats. A concise review based on current knowledge |journal=Vet Q |volume=28 |issue=2 |pages=66–73 |date=June 2006 |pmid=16841569 |doi= 10.1080/01652176.2006.9695210|url=}}</ref> and [[primate]]s and has been found in animals in Europe, [[Asia]], [[Africa]] and [[North America]]. The virus name is derived from the town of [[Borna, Leipzig|Borna]] in [[Saxony]], [[Germany]], which suffered an epidemic of the disease in horses in 1885. |
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Avian bornaviruses, a group of related viruses, have been reported, yet not proven, as the cause of [[proventricular dilatation disease]] (PDD), a disease of pet parrots. The use of a 'positive' brain cell culture containing ABV to inoculate another psittacine (parrot) bird resulted in the inoculated bird's death and subsequent histopathological diagnosis of PDD (mononuclear infiltrative ganglioneuritis). Earlier research with purified avian bornavirus inoculant (while did result in the death of parrots) did not reproduce histopathological changes associated with PDD.{{citation needed|date=February 2014}} |
Avian bornaviruses, a group of related viruses, have been reported, yet not proven, as the cause of [[proventricular dilatation disease]] (PDD), a disease of pet parrots. The use of a 'positive' brain cell culture containing ABV to inoculate another psittacine (parrot) bird resulted in the inoculated bird's death and subsequent histopathological diagnosis of PDD (mononuclear infiltrative ganglioneuritis). Earlier research with purified avian bornavirus inoculant (while did result in the death of parrots) did not reproduce histopathological changes associated with PDD.{{citation needed|date=February 2014}} |
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===Psychiatric disease=== |
===Psychiatric disease=== |
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There is some evidence that there may be a relationship between BoDV-1 infection and psychiatric disease.<ref name="pmid12857781">{{cite journal |vauthors=Bode L, Ludwig H |title=Borna disease virus infection, a human mental-health risk |journal=Clin. Microbiol. Rev. |volume=16 |issue=3 |pages=534–45 |date=July 2003 |pmid=12857781 |pmc=164222 |doi= 10.1128/CMR.16.3.534-545.2003 |
There is some evidence that there may be a relationship between BoDV-1 infection and psychiatric disease.<ref name="pmid12857781">{{cite journal |vauthors=Bode L, Ludwig H |title=Borna disease virus infection, a human mental-health risk |journal=Clin. Microbiol. Rev. |volume=16 |issue=3 |pages=534–45 |date=July 2003 |pmid=12857781 |pmc=164222 |doi= 10.1128/CMR.16.3.534-545.2003}}</ref><ref name="pmid2244211">{{cite journal |doi=10.1126/science.2244211 |vauthors=VandeWoude S, Richt JA, Zink MC, Rott R, Narayan O, Clements JE |title=A borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases |journal=Science |volume=250 |issue=4985 |pages=1278–81 |date=November 1990 |pmid=2244211 }}</ref> |
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In 1990, [[Janice E. Clements]] and colleagues reported in the journal ''[[Science (journal)|Science]]'' that antibodies to a protein encoded by the BoDV-1 genome are found in the blood of patients with behavioral disorders.<ref name="pmid2069502"/> In the early 1990s, researchers in Germany, America, and Japan conducted an investigation of 5000 patients with psychiatric disorders and 1000 controls, in which a significantly higher percentage of patients than controls were positive for BoDV-1 antibodies.<ref name="pmid2069502">{{cite journal |doi=10.1007/BF01314025 |vauthors=Rott R, Herzog S, Bechter K, Frese K |title=Borna disease, a possible hazard for man? |journal=Archives of Virology |volume=118 |issue= |
In 1990, [[Janice E. Clements]] and colleagues reported in the journal ''[[Science (journal)|Science]]'' that antibodies to a protein encoded by the BoDV-1 genome are found in the blood of patients with behavioral disorders.<ref name="pmid2069502"/> In the early 1990s, researchers in Germany, America, and Japan conducted an investigation of 5000 patients with psychiatric disorders and 1000 controls, in which a significantly higher percentage of patients than controls were positive for BoDV-1 antibodies.<ref name="pmid2069502">{{cite journal |doi=10.1007/BF01314025 |vauthors=Rott R, Herzog S, Bechter K, Frese K |title=Borna disease, a possible hazard for man? |journal=Archives of Virology |volume=118 |issue=3–4 |pages=143–9 |year=1991 |pmid=2069502 }}</ref> Subsequent studies have also presented evidence for an association between BoDV-1 and human psychiatric disorders.<ref name="pmid16324750">{{cite journal |vauthors=Miranda HC, Nunes SO, Calvo ES, Suzart S, Itano EN, Watanabe MA |title=Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients |journal=J Affect Disord |volume=90 |issue=1 |pages=43–7 |date=January 2006 |pmid=16324750 |doi=10.1016/j.jad.2005.10.008 |url=http://linkinghub.elsevier.com/retrieve/pii/S0165-0327(05)00300-9}}</ref><ref name="pmid11158085">{{cite journal |vauthors=Fukuda K, Takahashi K, Iwata Y |title=Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan |journal=J. Clin. Microbiol. |volume=39 |issue=2 |pages=419–29 |date=February 2001 |pmid=11158085 |pmc=87754 |doi=10.1128/JCM.39.2.419-429.2001 |display-authors=etal}}</ref><ref name="pmid9075304">{{cite journal |vauthors=Waltrip RW, Buchanan RW, Carpenter WT |title=Borna disease virus antibodies and the deficit syndrome of schizophrenia |journal=Schizophr. Res. |volume=23 |issue=3 |pages=253–7 |date=February 1997 |pmid=9075304 |doi= 10.1016/S0920-9964(96)00114-4|display-authors=etal}}</ref> However, not all researchers consider the link between BoDV-1 and human psychiatric disease to be conclusively proven. A study published in 2003 found no BoDV-1 antibodies in 62 patients with the deficit form of schizophrenia.<ref name="urlWiley InterScience :: JOURNALS :: Acta Neuropsychiatrica">{{cite web |url=http://www3.interscience.wiley.com/journal/118844334/abstract |title=Wiley InterScience :: JOURNALS :: Acta Neuropsychiatrica |format= |website= |accessdate=2009-01-20}}</ref> |
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Additional evidence for a role of BoDV-1 in psychiatric disorders comes from reports that the drug [[amantadine]], which is used to treat [[influenza]] infections, has had some success in treating depression and clearing BoDV-1 infection.<ref name="pmid11254023">{{cite journal |vauthors=Dietrich DE, Bode L, Spannhuth CW |title=Amantadine in depressive patients with Borna disease virus (BDV) infection: an open trial |journal=Bipolar Disord |volume=2 |issue=1 |pages=65–70 |date=March 2000 |pmid=11254023 |doi= 10.1034/j.1399-5618.2000.020110.x |
Additional evidence for a role of BoDV-1 in psychiatric disorders comes from reports that the drug [[amantadine]], which is used to treat [[influenza]] infections, has had some success in treating depression and clearing BoDV-1 infection.<ref name="pmid11254023">{{cite journal |vauthors=Dietrich DE, Bode L, Spannhuth CW |title=Amantadine in depressive patients with Borna disease virus (BDV) infection: an open trial |journal=Bipolar Disord |volume=2 |issue=1 |pages=65–70 |date=March 2000 |pmid=11254023 |doi= 10.1034/j.1399-5618.2000.020110.x|display-authors=etal}}</ref> Counter-claims state that Borna virus infections are not cleared by amantadine.{{Citation needed|date=August 2009}} The issue is further complicated by the fact that amantadine is also used in the treatment of [[Parkinson's disease]] and may have direct effects on the [[nervous system]]. |
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== References == |
== References == |
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Revision as of 00:00, 17 February 2019
| Borna disease viruses 1 and 2 | |
|---|---|
| Specialty | Veterinary medicine |
Borna disease is an infectious neurological syndrome[1] of warm-blooded animals, caused by Borna disease viruses 1 and 2 (BoDV-1/2), both of which are members of the species Mammalian 1 orthobornavirus. BoDV-1 and 2 cause abnormal behaviour and fatality. Borna disease viruses 1 and 2 are neurotropic viruses and members of the Bornaviridae family within the Mononegavirales order.
Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in horses and other animals, they are also controversially discussed as human infectious agents and therefore as potential zoonotic agents. The role of BoDV-1 and -2 in human illness is controversial and it is yet to be established whether BoDV-1 or -2 cause any overt disease in humans. However, correlative evidence exists linking BoDV-1/2 infection with neuropsychiatric disorders such as bipolar disorder.[2]
Animals affected
Borna diseases viruses 1 and 2 appear to have wide host ranges, having been detected in horses, cattle, sheep, dogs and foxes. In 1995, BoDV-1 was isolated from cats suffering from a "staggering disease" in Sweden. Since that time, BoDV-1 has also been detected in cats in Japan and Britain.
Borna virus has been detected in humans, and researchers have presented evidence connecting these infections with psychiatric disorders.[3][4][5]
Experimental infection of rats has been demonstrated to lead to learning impairments and altered social behaviour. The virus appears to be distributed primarily in the limbic system of the brain, including the hippocampus and entorhinal cortex. These areas of the brain are considered to be of importance in emotion.
Originally identified in sheep and horses[6] in Europe, it has since been found to occur in a wide range of warm-blooded animals including birds, cattle, cats[7] and primates and has been found in animals in Europe, Asia, Africa and North America. The virus name is derived from the town of Borna in Saxony, Germany, which suffered an epidemic of the disease in horses in 1885.
Avian bornaviruses, a group of related viruses, have been reported, yet not proven, as the cause of proventricular dilatation disease (PDD), a disease of pet parrots. The use of a 'positive' brain cell culture containing ABV to inoculate another psittacine (parrot) bird resulted in the inoculated bird's death and subsequent histopathological diagnosis of PDD (mononuclear infiltrative ganglioneuritis). Earlier research with purified avian bornavirus inoculant (while did result in the death of parrots) did not reproduce histopathological changes associated with PDD.[citation needed]
Borna disease in sheep and horses arises after a four-week incubation period followed by the development of immune-mediated meningitis and encephalomyelitis. Clinical manifestations vary but may include excited or depressed behaviour, ataxia, ocular disorders and abnormal posture and movement. Mortality rates are 80-100% in horses and greater than 50% in sheep.
Borna disease in the horse gives rise to signs like:
- Unusual posture, gait and ear positions
- Movement Disturbances (principally ataxia or excess movement)
Cause
| Orthobornavirus | |
|---|---|
| Virus classification | |
| Group: | Group V ((−)ssRNA)
|
| Order: | |
| Family: | |
| Genus: | |
| Species | |
|
Mammalian 1 orthobornavirus | |
Vectors
The mode of transmission of BoDV-1/2 is unclear but probably occurs through intranasal exposure to contaminated saliva or nasal secretions. Following infection, individuals may develop Borna disease, or may remain subclinical, possibly acting as a carrier of the virus.
History
The first antibodies to BoDV-1 in humans were discovered in the mid-1980s. Since then, there have been conflicting results from various studies in regards to whether an association exists between the agent and clinical disease. Antibodies to BoDV-1, which indicate prior infection, and BoDV-1 antigen have also been detected in blood donors.
Psychiatric disease
There is some evidence that there may be a relationship between BoDV-1 infection and psychiatric disease.[3][4]
In 1990, Janice E. Clements and colleagues reported in the journal Science that antibodies to a protein encoded by the BoDV-1 genome are found in the blood of patients with behavioral disorders.[5] In the early 1990s, researchers in Germany, America, and Japan conducted an investigation of 5000 patients with psychiatric disorders and 1000 controls, in which a significantly higher percentage of patients than controls were positive for BoDV-1 antibodies.[5] Subsequent studies have also presented evidence for an association between BoDV-1 and human psychiatric disorders.[8][9][10] However, not all researchers consider the link between BoDV-1 and human psychiatric disease to be conclusively proven. A study published in 2003 found no BoDV-1 antibodies in 62 patients with the deficit form of schizophrenia.[11]
Additional evidence for a role of BoDV-1 in psychiatric disorders comes from reports that the drug amantadine, which is used to treat influenza infections, has had some success in treating depression and clearing BoDV-1 infection.[12] Counter-claims state that Borna virus infections are not cleared by amantadine.[citation needed] The issue is further complicated by the fact that amantadine is also used in the treatment of Parkinson's disease and may have direct effects on the nervous system.
References
- ^ Ackermann A, Staeheli P, Schneider U (August 2007). "Adaptation of Borna disease virus to new host species attributed to altered regulation of viral polymerase activity". J. Virol. 81 (15): 7933–40. doi:10.1128/JVI.00334-07. PMC 1951315. PMID 17522214.
- ^ "(Quoted) Liv Bode - Robert Koch Institute, Ron Ferszt - Free University of Berlin" (August 31, 1998). "Research suggests virus may play role in depression". CNN Health. Archived from the original on March 3, 2012.
{{cite web}}: Unknown parameter|deadurl=ignored (|url-status=suggested) (help) - ^ a b Bode L, Ludwig H (July 2003). "Borna disease virus infection, a human mental-health risk". Clin. Microbiol. Rev. 16 (3): 534–45. doi:10.1128/CMR.16.3.534-545.2003. PMC 164222. PMID 12857781.
- ^ a b VandeWoude S, Richt JA, Zink MC, Rott R, Narayan O, Clements JE (November 1990). "A borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases". Science. 250 (4985): 1278–81. doi:10.1126/science.2244211. PMID 2244211.
- ^ a b c Rott R, Herzog S, Bechter K, Frese K (1991). "Borna disease, a possible hazard for man?". Archives of Virology. 118 (3–4): 143–9. doi:10.1007/BF01314025. PMID 2069502.
- ^ Dauphin G, Legay V, Pitel PH, Zientara S (2002). "Borna disease: current knowledge and virus detection in France". Vet. Res. 33 (2): 127–38. doi:10.1051/vetres:2002002. PMID 11944803.
- ^ Kamhieh S, Flower RL (June 2006). "Borna disease virus (BDV) infection in cats. A concise review based on current knowledge". Vet Q. 28 (2): 66–73. doi:10.1080/01652176.2006.9695210. PMID 16841569.
- ^ Miranda HC, Nunes SO, Calvo ES, Suzart S, Itano EN, Watanabe MA (January 2006). "Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients". J Affect Disord. 90 (1): 43–7. doi:10.1016/j.jad.2005.10.008. PMID 16324750.
- ^ Fukuda K, Takahashi K, Iwata Y, et al. (February 2001). "Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan". J. Clin. Microbiol. 39 (2): 419–29. doi:10.1128/JCM.39.2.419-429.2001. PMC 87754. PMID 11158085.
- ^ Waltrip RW, Buchanan RW, Carpenter WT, et al. (February 1997). "Borna disease virus antibodies and the deficit syndrome of schizophrenia". Schizophr. Res. 23 (3): 253–7. doi:10.1016/S0920-9964(96)00114-4. PMID 9075304.
- ^ "Wiley InterScience :: JOURNALS :: Acta Neuropsychiatrica". Retrieved 2009-01-20.
- ^ Dietrich DE, Bode L, Spannhuth CW, et al. (March 2000). "Amantadine in depressive patients with Borna disease virus (BDV) infection: an open trial". Bipolar Disord. 2 (1): 65–70. doi:10.1034/j.1399-5618.2000.020110.x. PMID 11254023.