'''2C-T-21''' is a [[psychedelic drug|psychedelic]] [[phenethylamine]] of the [[2C's|2C family]]. It was first synthesized by [[Alexander Shulgin]], sometimes used as an [[entheogen]]. It was the first psychedelic drug known to contain six different [[chemical element]]s in the structure.
'''2C-T-21''' is a [[psychedelic drug|psychedelic]] [[phenethylamine]] of the [[2C (psychedelics)|2C family]]. It was first synthesized by [[Alexander Shulgin]], sometimes used as an [[entheogen]].
==Chemistry==
==Chemistry==
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==Dangers==
==Dangers==
On March 9, 2004, a 22-year-old [[quadriplegic]] man named James Edwards Downs in St. Francisville, Louisiana, consumed an unknown dose of 2C-T-21 by sticking his tongue into a vial of powder he had purchased online. He developed a temperature of 108 degrees Fahrenheit (42 degrees Celsius),<ref name="urlNews from DEA, News Releases, 07/22/04">{{cite web |url=http://www.dea.gov/pubs/pressrel/pr072204.html |title=News from DEA, News Releases, 07/22/04 |work= |accessdate=}}</ref> had a [[tonic-clonic seizure]], and slipped into a coma. Four days later, on March 13, Downs died at Lane Memorial Hospital in Zachary, LA.{{Citation needed|date=December 2007}}
On March 9, 2004, a 22-year-old [[quadriplegic]] man named James Edwards Downs in St. Francisville, Louisiana, consumed an unknown dose of 2C-T-21 by sticking his tongue into a vial of powder he had purchased online. He developed a temperature of {{convert|108|F|C}},<ref name="urlNews from DEA, News Releases, 07/22/04">{{cite web |url=http://www.dea.gov/pubs/pressrel/pr072204.html |title=News from DEA, News Releases, 07/22/04 |work= |accessdate=}}</ref> had a [[tonic-clonic seizure]], and slipped into a coma. Four days later, on March 13, Downs died at Lane Memorial Hospital in Zachary, LA.{{Citation needed|date=December 2007}}
This death became part of a two-year DEA investigation called [[Operation Web Tryp]] which was launched in 2002. On July 22, 2004, the owners of American Chemical Supply were arrested on federal charges relating to distribution of [[Federal Analog Act|controlled substance analogues]] and the death of James Edwards Downs. Little is known about the toxicity of 2C-T-21 beyond this incident.
This death became part of a two-year DEA investigation called [[Operation Web Tryp]] which was launched in 2002. On July 22, 2004, the owners of American Chemical Supply were arrested on federal charges relating to distribution of [[Federal Analog Act|controlled substance analogues]] and the death of James Edwards Downs. Little is known about the toxicity of 2C-T-21 beyond this incident.
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===Canada===
===Canada===
As of October 31st, 2016; 2C-T-21 is a controlled substance (Schedule III) in Canada.http://gazette.gc.ca/rp-pr/p2/2016/2016-05-04/html/sor-dors72-eng.php
As of October 31st, 2016; 2C-T-21 is a controlled substance (Schedule III) in Canada.<ref>http://gazette.gc.ca/rp-pr/p2/2016/2016-05-04/html/sor-dors72-eng.php</ref>
2C-T-21 is generally taken orally, and effects typically last 7 to 14 hours. The potential psychotherapeutic applications of this chemical were explored by Myron Stolaroff who found it a very promising substance in his experiments.
Pharmacology
The mechanism that produces 2C-T-21’s hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT2Aserotonin receptoragonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known. Based on the relatively high potency of 2C-T-21, it is likely that this compound binds quite strongly to the 5HT2A receptor target.
Fluoroacetate is produced by S-dealkylation of 2C-T-21.
Dangers
On March 9, 2004, a 22-year-old quadriplegic man named James Edwards Downs in St. Francisville, Louisiana, consumed an unknown dose of 2C-T-21 by sticking his tongue into a vial of powder he had purchased online. He developed a temperature of 108 °F (42 °C),[2] had a tonic-clonic seizure, and slipped into a coma. Four days later, on March 13, Downs died at Lane Memorial Hospital in Zachary, LA.[citation needed]
This death became part of a two-year DEA investigation called Operation Web Tryp which was launched in 2002. On July 22, 2004, the owners of American Chemical Supply were arrested on federal charges relating to distribution of controlled substance analogues and the death of James Edwards Downs. Little is known about the toxicity of 2C-T-21 beyond this incident.
Legality
2C-T-21 is unscheduled and uncontrolled in the United States, but possession and sales of 2C-T-21 would probably be prosecuted under the Federal Analog Act because of its structural similarities to 2C-T-7 and its known potential to cause death. In the wake of Operation Web Tryp in July 2004, at least one "research chemical" distributor faced charges as a consequence of the death of James Downs from 2C-T-21 overdose.
Canada
As of October 31st, 2016; 2C-T-21 is a controlled substance (Schedule III) in Canada.[3]
