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Mukker File:Kranthi Mukkera.jpg It's my picture a Kranthi
Born	August 8th 1992 Bellampalli, Telangana state, India
Occupation	Engineer
Parent(s)	Mukkera Ramulu and sathyamma

Mukkera Kranthi Kumar'

Biography

Hello my name is Kranthiranthi Kumar and I'm 26years old,born of a non-consanguineous marriage, presented with clinical indications of radiculoncuropathy, cranial neuropathy and diarrhea.

2013 I was in home for a While, I started having diarrhoea after eating. Whatever i eat i had to go to bathroom and i got a terrible cough. I had a high fever. I consulted local MD , he prescribed some medications, after that I had to leave the home from my education. I used the medication for one month i felt good while using the medication and then I stopped taking medicine, same symptoms started again.

I begun to notice a wide range of debilitating symptoms. Again I had fever for one night, next day morning i noticed something wrong in my hands and feet, i couldn't feel the ground. I called my mom explained everything that i lost my ability to eat, walk and shirt buttoning and unbuttoning. Then I admitted in local hospital i was checked by a neurologist , they gave me steroids for five days and then they referred me to consult NIMS HOSPITAL (Hyderabad) which is best hospital in south India. The NIMS HOSPITAL doctor advised a test called ENMG , i got the reports immediately and I was treated with PLASMAPHERESIS for five days and they prescribed REJUNEX 500mg and GABAPENTIN 500mg , they thought it was GUILLAIN-BARRE SYNDROME. I used medication for three months i didnt feel any changes. One day I got fever and my eye sight decreased , Again I admitted in NIMS HOSPITAL and treated with IVIG for five days. Somehow my eye sight got improved to normal, remaining symptoms parastesia in both upper and lower limbs, unable to walk, unable to maintain body balance, swallowing difficulties, unable to stand with closed eyes. It went on six months swallowing difficulty became worst i consulted GI SPECIALIST, he suggested PEG TUBE and I agreed. In 2015 i was admitted in hospital with breathing difficulty doctors put me on pressurized ventilation system (Bi pap) I told him how i was feeling he took 6voils of blood samples for genetic analysis, and I had muscle biopsy. My test reports came back, he was slightly surprised that the tests came back negative, I did not know what was wrong with me. and also to the fact that no one else in my family has it. From there I went in for an EMG (Electromyogram) and learned how unreactive the muscle in my feet was. Though the blood results were negative, But,, I've only one mutation in a gene that is associated with Leigh syndrome The Gene NDUFV2 however the patients with Leigh syndrome should have two mutations in this Gene.

My life has been drastically changed by unknown disease. I take every chance I can to get proper diagnosis, I went to specialists all over the country, for a "diagnosis” I ever heard of and some I didn’t even know existed. A full exome sequencing revealed nothing, I've consulted the best neurologists in India from NIMS have not been able to tell me why or give me a definitive treatment plan. I’ve been subjected to countless tests, , biopsies, blood draws, with no clear answer of how to improve my quality of day-to-day life. In my situation, I became ill and went undiagnosed for a year. I endured many medical tests and they would all come back negative. When tests came back negative for certain conditions, doctors would give up on trying to find answers. They were incredibly confused by my complex illness, so they abandoned me. I just wanted a doctor that waas willing to help me and to get treatment for whatever it was that was affecting me. During this time, I prayed every night to be provided with answers and/or have my illness improve or disappear. I also tried a wide variety of treatments because I was so desperate to get better, including homeopathic remedies and natural medicines. When I became suddenly ill, I craved having my old life Back and I still do..

SYMPTOMS

paresthesias in hands & feet, swaying while walking, weakness of handgrip, I was apparently asymptomatic when he had fever of I day duration, high grade, continuous fever, lasted for 1 day. 3 days later, patient notized tingling paresthesias in both the feet & hands started almcst simultaneously & progressively increased in seventy & ascended up te legs till inees Ho feeling of numbness in both the feet+, associated with decressed feeling of ground sensation. swaying while walking persisted. No bo sippage of sandles from foot with/ without knowledge. Ho difficulty in holding the objects in hands+ No difficulty in rising shoulicr No difficulry in turning in be. No h'o droopirg of eyelids dtplopia / decreased vision No h'o dysphagia/Dysarthria ' nasal regurgtation/chocking spells. No hio bladder /bowel dysfinction. Past Ilistory: No h/o similaz compleint in the pas Not a known HTN DMM No h/o receat vaccination.