C6orf62: Difference between revisions
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== Protein == |
== Protein == |
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The main transcript is 229 amino acids long and is encoded from 5 exonic regions. There exists two transcript variants that are 200 amino acids and 160 amino acids long. There is a [[domain of unknown function]] (DUF4566) present in all three variants and spans positions 1-226 on the main transcript.<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/gene/81688|title=C6orf62 chromosome 6 open reading frame 62 [Homo sapiens (human)] - Gene - NCBI|website=www.ncbi.nlm.nih.gov|access-date=2017-05-08}}</ref> The molecular weight of C6orf62 is 27.1 kDa and its [[isoelectric point]] is at a pH of 9.24.<ref>{{Cite web| |
The main transcript is 229 amino acids long and is encoded from 5 exonic regions. There exists two transcript variants that are 200 amino acids and 160 amino acids long. There is a [[domain of unknown function]] (DUF4566) present in all three variants and spans positions 1-226 on the main transcript.<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/gene/81688|title=C6orf62 chromosome 6 open reading frame 62 [Homo sapiens (human)] - Gene - NCBI|website=www.ncbi.nlm.nih.gov|access-date=2017-05-08}}</ref> The molecular weight of C6orf62 is 27.1 kDa and its [[isoelectric point]] is at a pH of 9.24.<ref>{{Cite web|https://www.priyamstudycentre.com/2018/08/concept-of-ph.html|title=priyam-study-centre-concept-of-pH|last=Volker|first=Brendel|date=2006|website=Priyam Study Centre|archive-url=|archive-date=|dead-url=|access-date=2017-05-01}}{{retrive|date=July 2019 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> It is located subcellularly localized throughout the cytosol.<ref name=":0" /> |
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=== Protein Interactions === |
=== Protein Interactions === |
Revision as of 12:00, 18 June 2019
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | C6orf62, Nbla00237, XTP12, dJ30M3.2, chromosome 6 open reading frame 62 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 2441726; HomoloGene: 11551; GeneCards: C6orf62; OMA:C6orf62 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Chromosome 6 open reading frame 62 (C6orf62), also known as X-trans-activated protein 12 (XTP12),[5] is a gene that encodes a protein of the same name. The encoded protein is predicted to have a subcellular location within the cytosol.[6]
Gene and Transcript
In the DNA, C6orf62 is 12,529 base pairs long and is located at 6q22.3.[7] It is located on chromosome 6 on position 22.3 (6q22.3). The mature mRNA sequence is 2498 base-pairs long with 5 exons and 4 intronic regions that translates a protein that is 229 amino acids long and two predicted isoforms of 160 amino acids and 200 amino acids.[8][9]
Protein
The main transcript is 229 amino acids long and is encoded from 5 exonic regions. There exists two transcript variants that are 200 amino acids and 160 amino acids long. There is a domain of unknown function (DUF4566) present in all three variants and spans positions 1-226 on the main transcript.[10] The molecular weight of C6orf62 is 27.1 kDa and its isoelectric point is at a pH of 9.24.[11] It is located subcellularly localized throughout the cytosol.[6]
Protein Interactions
Protein | |
ELAVL1 | predicted through affinity capture-RNA.[12] |
PVRL4 | predicted through affinity capture-mass spectroscopy.[12] |
NADH | predicted through yeast two-hybrid screening.[13] |
Expression
C6orf62 is broadly expressed within the human body, however, its protein abundance is not high.[14] It is more heavily expressed in the gallbladder and testis, but it is not predicted to be expressed in the smooth muscle, lymph nodes, the spleen, ovaries, adipose tissue, and soft tissue.
Homology
C6orf62 is highly conserved among vertebrates and has orthologs found in invertebrates.
Orthologs in Select Mammals[15]
Genus | Species | Common Name | Date of divergence (MYA) | RefSeq | AA Length | % Identity | % Similarity |
Pongo | abelii | Sumatran Orangutan | 15.2 | NP_001126883.1 | 232 | 99 | 99 |
Ictidomys | tridecemlineatus | Ground Squirrel | 88 | XP_005337081.1 | 231 | 99 | 98 |
Tupaia | chinensis | Treeshrew | 85 | XP_006162754.1 | 267 | 84 | 98 |
Rattus | norvegicus | Brown Rat | 88 | NP_001017510.1 | 232 | 99 | 98 |
Orthologs in Select Ray-Finned Fish[15]
Genus | Species | Common Name | Date of divergence (MYA) | RefSeq | AA Length | % Identity | % Similarity |
Salmo | salar | Salmon | 435 | XP_014034327.1 | 233 | 82 | 93 |
Sinocyclocheilus | rhinoceros | Golden-lined Barbell | 435 | XP_016388718.1 | 230 | 87 | 94 |
Hippocampus | comes | Seahorse | 435 | XP_019729847.1 | 234 | 80 | 91 |
Orthologs in Select Amphibians[15]
Genus | Species | Common Name | Date of divergence (MYA) | RefSeq | AA Length | % Identity | % Similarity |
Nanorana | parkeri | High Himalaya Frog | 353 | XP_018411819.1 | 232 | 95 | 97 |
Xenopus | trpocalis | African Clawed Frog | 353 | NP_001120278.1 | 232 | 93 | 98 |
Orthologs in Select Reptiles[15]
Genus | Species | Common Name | Date of divergence (MYA) | RefSeq | AA Length | % Identity | % Similarity |
Chrysemys | picta belli | Painted Turtle | 320 | XP_005281462.1 | 233 | 97 | 98 |
Python | vbivittatus | Burmese Python | 320 | XP_007521998.1 | 233 | 96 | 99 |
Chelonia | mydas | Green Sea Turtle | 320 | XP_007060449.1 | 231 | 97 | 98 |
Alligator | sinensis | Chinese Alligator | 320 | XP_006034488.1 | 232 | 98 | 99 |
Orthologs in Select Birds[15]
Genus | Species | Common Name | Date of divergence (MYA) | RefSeq | AA Length | % Identity | % Similarity |
Tauraco | erythrolophus | Red-crested Tauraco | 320 | XP_009991398.1 | 232 | 97 | |
Taeniopygia | guttata | Zebra Finch | 320 | XP_002194166.1 | 232 | 98 | |
Manacus | vitellinus | Gold Marked Manakin | 320 | XP_017925511.1 | 241 | 98 |
Orthologs in Select Invertebrates[15]
Genus | Species | Common Name | Date of divergence (MYA) | RefSeq | AA Length | % Identity | % Similarity |
Ciona | intestinalis | Sea Squirt | 677 | XP_002119736.1 | 233 | 38 | 62 |
Crassostrea | gigas | Pacific Oyster | 758 | XP_011438527.1 | 231 | 62 | 80 |
Hellobdella | robusta | Glossiphoniidae Leech | 758 | XP_009016977.1 | 264 | 35 | 51 |
Octopus | bimaculoides | Two-Spot Octopus | 758 | XP_014780369.1 | 197 | 60 | 79 |
Saccoglossus | kowalevskii | Acorn Worm | 627 | XP_002741666.1 | 230 | 66 | 83 |
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000112308 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019132 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Database, GeneCards Human Gene. "C6orf62 Gene - GeneCards | CF062 Protein | CF062 Antibody". www.genecards.org. Retrieved 2017-02-21.
- ^ a b "Tissue expression of C6orf62 - Summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2017-05-08.
- ^ Kent, WJ; Sugnet, CW; Furey, TS; Roskin, KM; Pringle, TH; Zahler, AM; Haussler, D (2002). "UCSC Genome Browser". UCSC Genome Browser. Retrieved 2017-02-20.
{{cite web}}
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(help) - ^ "PREDICTED: uncharacterized protein C6orf62 isoform X1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-05-08.
- ^ "PREDICTED: uncharacterized protein C6orf62 isoform X2 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-05-08.
- ^ "C6orf62 chromosome 6 open reading frame 62 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-05-08.
- ^ Volker, Brendel (2006). "priyam-study-centre-concept-of-pH". Priyam Study Centre.
{{cite web}}
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(help); Text "https://www.priyamstudycentre.com/2018/08/concept-of-ph.html" ignored (help)Template:Retrive - ^ a b Lab, Mike Tyers. "C6orf62 (RP1-30M3.4) Result Summary | BioGRID". thebiogrid.org. Retrieved 2017-05-08.
- ^ "1 binary interaction found for search term C6orf62". IntAct Molecular Interaction Database. EMBL-EBI. Retrieved 2018-08-25.
- ^ "C6orf62 protein abundance in PaxDb". pax-db.org. Retrieved 2017-05-08.
- ^ a b c d e f "NCBI - Basic Local Alignment Search Tool". NCBI.
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