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Updated infobox
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| foundation = 1990
| foundation = 1990
| founder = [[Richard A. Friesner]],<br />[[William Andrew Goddard III|William A. Goddard III]]
| founder = [[Richard A. Friesner]],<br />[[William Andrew Goddard III|William A. Goddard III]]
| location =[[New York, NY]]
| location = [[New York, NY]]
| key_people = Ramy Farid (President & CEO), [[Michael Lynton]] (Chairman of the Board)
| key_people = Ramy Farid (President & CEO), [[Michael Lynton]] (Chairman of the Board)
| industry = {{flatlist|
| industry = {{flatlist|
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| area_served = Worldwide
| area_served = Worldwide
| products = {{flatlist|
| products = {{flatlist|
*Advanced computational platform for drug discovery and materials science
*Small-Molecule Drug Discovery Suite
*LiveDesign
*Biologics Suite
*Materials Science Suite
*Discovery Informatics Suite
*PyMOL
*PyMOL
}}
}}

Revision as of 17:27, 24 June 2019

Schrödinger
Company typePrivate
Industry
Founded1990
FounderRichard A. Friesner,
William A. Goddard III
HeadquartersNew York, NY
Area served
Worldwide
Key people
Ramy Farid (President & CEO), Michael Lynton (Chairman of the Board)
Products
  • Advanced computational platform for drug discovery and materials science
  • LiveDesign
  • PyMOL
Number of employees
400
Websitewww.schrodinger.com

Schrödinger's industry-leading computational platform is deployed by leading pharmaceutical, biotechnology, chemical, and electronics companies worldwide to accelerate R&D in both drug discovery and materials design. Schrödinger has built a robust pipeline of therapeutic assets, held both internally and in partnerships, and has co-founded leading biotech companies, including Nimbus Therapeutics[1] and Morphic Therapeutic.[2] Schrödinger's significant and ongoing investment in basic research continues to drive advances in its computational platform.

Founded in 1990[3], Schrödinger has approximately 400 employees in its New York City headquarters and around the world.[4]

Company

Schrödinger is headquartered in New York, but also has offices around the world including several offices in the U.S., two offices in Germany, and offices in India, Japan, the UK, and China.[5] Bill Gates has invested a total of $100 million in Schrödinger since 2010.[6][7][8][9] David E. Shaw is also a major investor in the company.[9][10] The company is built on nearly 30 years of R&D investments which ensure continued scientific and commercial leadership.

In 2019, Schrödinger closed a funding round of $110 million led by the Bill and Melinda Gates Foundation Trust and WuXi AppTec's Corporate Venture Fund.[9][11][4][10] Other investors included Baron, Deerfield Management, GV (formerly Google Ventures), Invus, Laurion, Pavilion, Qiming Venture Partners, and Oculus co-founder Michael Antonov through his investment fund, Tubus Management.[9][11][4][10]

Schrödinger is a co-founder of Nimbus Therapeutics[1], Morphic Therapeutic[2], Bright Angel Therapeutics[12] and Faxian Therapeutics.[13]

Products

Schrödinger's platform integrates physics-based predictive simulation and machine learning to power “computational assays,” which evaluate compounds in silico with experimental accuracy on properties such as binding affinity and solubility. Schrödinger's full product offerings include molecular modeling programs and LiveDesign, an enterprise application designed to facilitate real-time collaboration and communication among interdisciplinary research teams around the globe.[14] The full computational platform is used by nearly all major biopharma companies to speed drug discovery.[15] It is used as well in an increasing number of industries, including organic light emitting diodes and energy storage, to accelerate and improve materials design.

Services

In addition to its computational platforms, Schrödinger provides professional services including custom software development and training,[16] computer-cluster design and implementation, and research-based drug discovery projects.[17][18][19][20][21] These professional services are provided to commercial, academic, and government organizations to assist with small-molecule design, biologics design, materials science applications, and implementation of enterprise-level informatics.[20][22]

Pipeline

Schrödinger has a highly differentiated pipeline including a number of partnerships and wholly owned programs.[23] Schrödinger's partners include larger pharmaceutical companies, including Takeda[24] and Sanofi[25], as well as many biotech startups around the world. These partnerships have already led to two FDA-approved oncology drugs, several more clinical-stage assets and more than two dozen additional programs moving through discovery and development.[26]

Nimbus Therapeutics, co-founded by Schrödinger[1], uses Schrödinger's drug screening and design platform in combination with a virtual, globally distributed model for drug discovery. In 2016, Nimbus Therapeutics sold an Acetyl-CoA Carboxylase (ACC) inhibitor designed by Schrödinger to Gilead in a deal worth up to $1.2 billion.[27] As of spring 2019 the ACC inhibitor was moving through late-stage clinical trials in NASH.[28] In 2018, Morphic Therapeutic, also co-founded by Schrödinger[2], struck a multi-target deal with AbbVie to collaborate on the development of therapies for fibrotic diseases[29] and in 2019 with Janssen (facilitated by Johnson & Johnson Innovation, Boston) on undisclosed integrin targets.[30] Both of Morphic's partnerships will advance therapies designed through Schrödinger's computational platform.

Schrödinger recently launched their own world-class internal drug discovery programs, leveraging the deep experience in cross-functional drug discovery of its internal team. The wholly owned programs will initially be focused on oncology but will add new programs in 2019.[31]

Awards and recognition

In recognition of his contributions to original research in the field of computational chemistry, Schrödinger founder Prof. Richard A. Friesner was elected to the National Academy of Sciences in 2016,[32] and to the American Academy of Arts and Sciences in 2008.[33][34] In 2014, Schrödinger was awarded the BioIT World Best Practices Award in the category of IT Infrastructure.[22][35] In September 2013, Nimbus Therapeutics, which was co-founded by Schrödinger[1], was named one of Fierce Biotech's "2013 Fierce 15" in recognition of the company's novel business strategies and technology.[36]

In November 2013, Schrödinger, in collaboration with Cycle Computing and the University of Southern California set a record for the world's largest and fastest cloud computing run by using 156,000 cores on Amazon Web Services to screen over 205,000 molecules for materials science research.[37] This work was a follow up to a collaboration in 2012 in which Cycle Computing created a 50,000 core virtual supercomputer using Amazon infrastructure and Schrödinger's Glide program was used to analyze 2.1 million compounds in only 3 hours.[38]

See also

Other institutions developing software for computational chemistry:

References

  1. ^ a b c d "Nimbus - About Us". Retrieved 2019-06-19. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  2. ^ a b c "Morphic Therapeutic Announces $51.5 Million Series A Financing to Develop Next-Generation Integrin Therapies – Morphic Therapeutic". Retrieved 2019-06-19.
  3. ^ "Crunchbase, Schrodinger". {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  4. ^ a b c "Schrödinger Announces Close of Latest Financing, Raising Total of $110 Million | Schrödinger". www.schrodinger.com. Retrieved 2019-06-19.
  5. ^ "Contact | Schrödinger". www.schrodinger.com. Retrieved 2019-06-19.
  6. ^ Siemers, Erik (24 May 2010). ""Bill Gates' cash boosts drug company Schrodinger LLC"". Portland Business Journal. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  7. ^ Siemers, Erik (December 2012). ""Schrodinger receives another $20M from Bill Gates"". Portland Business Journal. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  8. ^ Tong, Amber (January 6, 2019). "Bill Gates backs Schrödinger's $85M venture raise for its standout computational drug discovery platform". Endpoints News. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  9. ^ a b c d Tong, Amber (May 20, 2019). "Additional backing arms Schrödinger with $110M in first venture round — shining a spotlight on its own pipeline". Endpoints News. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  10. ^ a b c Kuchler, Hannah (May 19, 2019). "Gates-backed computing platform raises $110m for new drug push". Financial Times. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  11. ^ a b Paul Taylor, Nick (May 20, 2019). "Schrödinger raises more cash, amassing $110M for R&D drive". FierceBiotech. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  12. ^ Currie, Michelle (January 5, 2018). "The light is bright for new therapeutics company in Toronto". Biotechnology Focus. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  13. ^ Tong, Amber (October 30, 2018). "WuXi dives into computational drug discovery, launches New York-based JV with Schrödinger". Endpoints News. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  14. ^ "LiveDesign". {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  15. ^ "Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors". Journal of Medicinal Chemistry. March 13, 2017.
  16. ^ "Training | Schrödinger". www.schrodinger.com. Retrieved 2019-06-19.
  17. ^ "Academic Licensing | Schrödinger". www.schrodinger.com. Retrieved 2019-06-19.
  18. ^ "Schrödinger and Tri-Institutional Therapeutics Discovery Institute Announce Agreement to Provide Drug Discovery Software to Tri-Institutional Researchers". Sep 2013. Retrieved 20 October 2014.
  19. ^ "Nimbus - Alliances". Oct 2014. Retrieved 20 October 2014.
  20. ^ a b "The Nimbus Experiment: Structure-Based Drug Deals". June 2013. Retrieved 20 October 2014.
  21. ^ "Schrodinger and Professor Mark E. Thompson (USC) Announce Research Collaboration to Enable Computer'Aided Design of Organic Semiconductor Materials". June 2013. Retrieved 20 October 2014.
  22. ^ a b "bioit". July 2013. Retrieved 20 October 2014.
  23. ^ "Drug Discovery Programs | Schrödinger". www.schrodinger.com. Retrieved 2019-06-19.
  24. ^ Liu, Angus (July 20, 2017). "Takeda, Schrödinger form multiprogram drug discovery pact". FierceBiotech. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  25. ^ Carroll, John (April 2, 2015). "Partnering Sanofi adds a $120M computational drug design deal with Schrödinger". FierceBiotech. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  26. ^ "Drug Discovery Programs | Schrödinger". www.schrodinger.com. Retrieved 2019-06-19.
  27. ^ "Gilead Sciences Announces Acquisition of Nimbus Therapeutics' Acetyl-CoA Carboxlyase (ACC) Program for NASH and Other Liver Diseases". www.businesswire.com. 2016-04-04. Retrieved 2019-06-19.
  28. ^ "Gilead Announces Topline Data From Phase 3 STELLAR-3 Study of Selonsertib in Bridging Fibrosis (F3) Due to Nonalcoholic Steatohepatitis (NASH)". www.gilead.com. Retrieved 2019-06-19.
  29. ^ Al Idrus, Amirah (October 18, 2018). "AbbVie partners with Morphic on fibrosis R&D—to the tune of $100M". FierceBiotech. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  30. ^ Taylor, Phil (February 21, 2019). "Morphic bags J&J as second big pharma partner for oral integrins". FierceBiotech. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  31. ^ "Drug Discovery Programs | Schrödinger". www.schrodinger.com. Retrieved 2019-06-19.
  32. ^ National Academy of Sciences Members and Foreign Associates Elected
  33. ^ American Academy of Arts & Sciences 2008 Class of Fellows and Foreign Honorary Members
  34. ^ 2008 Class of Fellows and Foreign Honorary Members
  35. ^ "The Cloud's the Limit: Rentable Supercomputers for Improving Drug Discovery". July 2011. Retrieved 20 October 2014.
  36. ^ "Nimbus Discovery - 2013 Fierce 15". FierceBiotech. 2013. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  37. ^ Shankland, Stephen (November 12, 2013). "Supercomputing simulation employs 156,000 Amazon processor cores". CNet. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  38. ^ Brodkin, Jon (April 19, 2012). "$4,829-per-hour supercomputer built on Amazon cloud to fuel cancer research". Ars Technica. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
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