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* [[CD44]],<ref name = "pmid14634662" />
* [[CD44]],<ref name = "pmid14634662" />
* [[GNA12]],<ref name = pmid14634662/>
* [[GNA12]],<ref name = pmid14634662/>
* [[GNA13]],<ref name = "pmid14634662">{{cite journal | vauthors = Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM | title = RGS16 inhibits signalling through the G alpha 13-Rho axis | journal = Nat. Cell Biol. | volume = 5 | issue = 12 | pages = 1095–103 | pmid = 14634662 | doi = 10.1038/ncb1065 }}</ref><ref name = pmid12681510>{{cite journal | vauthors = Bhattacharyya R, Wedegaertner PB | title = Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment | journal = FEBS Lett. | volume = 540 | issue = 1-3 | pages = 211–6 | date = Apr 2003 | pmid = 12681510 | doi = 10.1016/s0014-5793(03)00267-9}}</ref><ref name = pmid9641916>{{cite journal | vauthors = Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G | title = Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13 | journal = Science | volume = 280 | issue = 5372 | pages = 2112–4 | date = Jun 1998 | pmid = 9641916 | doi = 10.1126/science.280.5372.2112}}</ref> and
* [[GNA13]],<ref name = "pmid14634662">{{cite journal | vauthors = Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM | title = RGS16 inhibits signalling through the G alpha 13-Rho axis | journal = Nat. Cell Biol. | volume = 5 | issue = 12 | pages = 1095–103 | pmid = 14634662 | doi = 10.1038/ncb1065 | url = https://zenodo.org/record/1233351 }}</ref><ref name = pmid12681510>{{cite journal | vauthors = Bhattacharyya R, Wedegaertner PB | title = Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment | journal = FEBS Lett. | volume = 540 | issue = 1–3 | pages = 211–6 | date = Apr 2003 | pmid = 12681510 | doi = 10.1016/s0014-5793(03)00267-9}}</ref><ref name = pmid9641916>{{cite journal | vauthors = Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G | title = Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13 | journal = Science | volume = 280 | issue = 5372 | pages = 2112–4 | date = Jun 1998 | pmid = 9641916 | doi = 10.1126/science.280.5372.2112}}</ref> and
* [[P110α]]<ref name = pmid12754211>{{cite journal | vauthors = Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB | title = Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement | journal = J. Biol. Chem. | volume = 278 | issue = 31 | pages = 28793–8 | date = Aug 2003 | pmid = 12754211 | doi = 10.1074/jbc.M303900200 }}</ref>
* [[P110α]]<ref name = pmid12754211>{{cite journal | vauthors = Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB | title = Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement | journal = J. Biol. Chem. | volume = 278 | issue = 31 | pages = 28793–8 | date = Aug 2003 | pmid = 12754211 | doi = 10.1074/jbc.M303900200 }}</ref>


Revision as of 08:26, 28 June 2019

ARHGEF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGEF1, GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5, Rho guanine nucleotide exchange factor 1, IMD62
External IDsOMIM: 601855; MGI: 1353510; HomoloGene: 3454; GeneCards: ARHGEF1; OMA:ARHGEF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9138

16801

Ensembl

ENSG00000076928

ENSMUSG00000040940

UniProt

Q92888

Q61210

RefSeq (mRNA)

NM_004706
NM_198977
NM_199002

NM_001130150
NM_001130151
NM_001130152
NM_001130153
NM_008488

RefSeq (protein)

NP_004697
NP_945328
NP_945353

NP_001123622
NP_001123623
NP_001123624
NP_001123625
NP_032514

Location (UCSC)Chr 19: 41.88 – 41.93 MbChr 7: 24.6 – 24.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene.[5][6][7]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[7]

Interactions

ARHGEF1 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000076928 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040940 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P, Bollag G (Nov 1996). "Identification of a novel guanine nucleotide exchange factor for the Rho GTPase". J Biol Chem. 271 (41): 25452–8. doi:10.1074/jbc.271.41.25452. PMID 8810315.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  6. ^ Aasheim HC, Pedeutour F, Smeland EB (May 1997). "Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues". Oncogene. 14 (14): 1747–52. doi:10.1038/sj.onc.1200994. PMID 9135076.
  7. ^ a b "Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1".
  8. ^ a b c Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM. "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nat. Cell Biol. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.
  9. ^ Bhattacharyya R, Wedegaertner PB (Apr 2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Lett. 540 (1–3): 211–6. doi:10.1016/s0014-5793(03)00267-9. PMID 12681510.
  10. ^ Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G (Jun 1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science. 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. PMID 9641916.
  11. ^ Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB (Aug 2003). "Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement". J. Biol. Chem. 278 (31): 28793–8. doi:10.1074/jbc.M303900200. PMID 12754211.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Further reading

  • Fukuhara S, Chikumi H, Gutkind JS (2001). "RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?". Oncogene. 20 (13): 1661–8. doi:10.1038/sj.onc.1204182. PMID 11313914.
  • Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG, Bollag G, Sternweis PC (1998). "p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13". Science. 280 (5372): 2109–11. doi:10.1126/science.280.5372.2109. PMID 9641915.
  • Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G (1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science. 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. PMID 9641916.
  • Zhang H, Wang L, Kao S, Whitehead IP, Hart MJ, Liu B, Duus K, Burridge K, Der CJ, Su L (1999). "Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF". Curr. Biol. 9 (21): 1271–4. doi:10.1016/S0960-9822(99)80511-9. PMID 10556093.
  • Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Bhattacharyya R, Wedegaertner PB (2000). "Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding". J. Biol. Chem. 275 (20): 14992–9. doi:10.1074/jbc.M000415200. PMID 10747909.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Kozasa T (2001). "Regulation of G protein-mediated signal transduction by RGS proteins". Life Sci. 68 (19–20): 2309–17. doi:10.1016/S0024-3205(01)01020-7. PMID 11358341.
  • Wells CD, Gutowski S, Bollag G, Sternweis PC (2001). "Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor". J. Biol. Chem. 276 (31): 28897–905. doi:10.1074/jbc.M102913200. PMID 11384980.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Chen Z, Wells CD, Sternweis PC, Sprang SR (2001). "Structure of the rgRGS domain of p115RhoGEF". Nat. Struct. Biol. 8 (9): 805–9. doi:10.1038/nsb0901-805. PMID 11524686.
  • Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D (2003). "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation". J. Biol. Chem. 277 (47): 45361–70. doi:10.1074/jbc.M202447200. PMID 12270917.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (2002). "B plexins activate Rho through PDZ-RhoGEF". FEBS Lett. 529 (2–3): 168–72. doi:10.1016/S0014-5793(02)03323-9. PMID 12372594.
  • Chen Z, Singer WD, Wells CD, Sprang SR, Sternweis PC (2003). "Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF". J. Biol. Chem. 278 (11): 9912–9. doi:10.1074/jbc.M212695200. PMID 12525488.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Bhattacharyya R, Wedegaertner PB (2003). "Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF". Biochem. J. 371 (Pt 3): 709–20. doi:10.1042/BJ20021897. PMC 1223324. PMID 12534370.
  • Bhattacharyya R, Wedegaertner PB (2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Lett. 540 (1–3): 211–6. doi:10.1016/S0014-5793(03)00267-9. PMID 12681510.
  • Bourguignon LY, Singleton PA, Zhu H, Diedrich F (2003). "Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression". J. Biol. Chem. 278 (32): 29420–34. doi:10.1074/jbc.M301885200. PMID 12748184.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB (2003). "Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement". J. Biol. Chem. 278 (31): 28793–8. doi:10.1074/jbc.M303900200. PMID 12754211.{{cite journal}}: CS1 maint: unflagged free DOI (link)


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