Climbazole: Difference between revisions
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'''Climbazole''' |
'''Climbazole''' is a topical [[Antifungal medication|antifungal]] agent commonly used in the treatment of human fungal skin infections such as [[Seborrhoeic dermatitis|dandruff]]<ref name=pmid11534318>{{cite journal |pmid=11534318 |year=2001 |last1=Wigger-Alberti |first1=W |last2=Kluge |first2=K |last3=Elsner |first3=P |title=Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema |volume=90 |issue=33 |pages=1346–9 |journal=Praxis}}</ref> and [[eczema]]. Climbazole has shown a high ''in vitro'' and ''in vivo'' efficacy against ''[[Pityrosporum ovale]]'' that appears to play an important role in the pathogenesis of dandruff.<ref name=pmid11534318/> Its chemical structure and properties are similar to other fungicides such as [[ketoconazole]] and [[miconazole]]. |
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==Indications and formulations== |
==Indications and formulations== |
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Revision as of 10:14, 25 August 2019
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| Routes of administration | topical |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.048.870 |
| Chemical and physical data | |
| Formula | C15H17ClN2O2 |
| Molar mass | 292.76 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
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Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff[2] and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff.[2] Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.
Indications and formulations
It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.
Side effects
May cause localized irritation of the skin with symptoms including redness, rashes and itching.[citation needed]
References
- ^ Chemical Properties of Climbazole Archived 2007-11-13 at the Wayback Machine
- ^ a b Wigger-Alberti, W; Kluge, K; Elsner, P (2001). "Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema". Praxis. 90 (33): 1346–9. PMID 11534318.