FABP6: Difference between revisions

FABP6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1O1U, 1O1V, 2MM3
Identifiers
Aliases	FABP6, I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP, fatty acid binding protein 6
External IDs	OMIM: 600422; MGI: 96565; HomoloGene: 1108; GeneCards: FABP6; OMA:FABP6 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	160,238,735 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	43,492,367 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; right uterine tube; ; bronchial epithelial cell; ; olfactory zone of nasal mucosa; ; nucleus accumbens; ; caudate nucleus; ; putamen; ; testicle; ; Hypothalamus; ; substantia nigra;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; Paneth cell; ; ileum; ; intestinal villus; ; conjunctival fornix; ; blastocyst; ; epithelium of small intestine; ; Ileal epithelium; ; esophagus; ; cornea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	bile acid binding; lipid binding;
Cellular component	cytoplasm; cytosol; membrane;
Biological process	lipid metabolism; triglyceride catabolic process; negative regulation of cell population proliferation; lipid transport;
	Sources:Amigo / QuickGO
Orthologs
	2172
	16204
	ENSG00000170231
	ENSMUSG00000020405
	P51161
	P51162
	NM_001040442; NM_001130958; NM_001445
	NM_008375
	NP_001035532; NP_001124430; NP_001436
	NP_032401
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 21:49, 26 August 2019

Fatty acid binding protein 6, ileal (gastrotropin), also known as FABP6, is a protein which in humans is encoded by the FABP6 gene.^[5]

Function

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170231 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020405 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: FABP6 fatty acid binding protein 6, ileal (gastrotropin)".

Börchers T, Hohoff C, Buhlmann C, Spener F (1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation". Prostaglandins Leukot. Essent. Fatty Acids. 57 (1): 77–84. doi:10.1016/S0952-3278(97)90496-8. PMID 9250612.
Fujita M, Fujii H, Kanda T, et al. (1995). "Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein". Eur. J. Biochem. 233 (2): 406–413. doi:10.1111/j.1432-1033.1995.406_2.x. PMID 7588781.
Oelkers P, Dawson PA (1995). "Cloning and chromosomal localization of the human ileal lipid-binding protein". Biochim. Biophys. Acta. 1257 (2): 199–202. doi:10.1016/0005-2760(95)00098-w. PMID 7619861.
Birkenmeier EH, Rowe LB, Crossman MW, Gordon JI (1995). "Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11". Mamm. Genome. 5 (12): 805–806. doi:10.1007/BF00292019. PMID 7894165.
Watanabe K, Hoshi N, Tsuura Y, et al. (1996). "Immunohistochemical distribution of intestinal 15 kDa protein in human tissues". Arch. Histol. Cytol. 58 (3): 303–306. doi:10.1679/aohc.58.303. PMID 8527237.
Lücke C, Zhang F, Rüterjans H, et al. (1997). "Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein". Structure. 4 (7): 785–800. doi:10.1016/S0969-2126(96)00086-X. PMID 8805562.
Grober J, Zaghini I, Fujii H, et al. (1999). "Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer". J. Biol. Chem. 274 (42): 29749–29754. doi:10.1074/jbc.274.42.29749. PMID 10514450.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Seibert C, Harteneck C, Ernst OP, et al. (2000). "Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells". Eur. J. Biochem. 266 (3): 911–916. doi:10.1046/j.1432-1327.1999.00927.x. PMID 10583385.
Lücke C, Zhang F, Hamilton JA, et al. (2000). "Solution structure of ileal lipid binding protein in complex with glycocholate". Eur. J. Biochem. 267 (10): 2929–2938. doi:10.1046/j.1432-1327.2000.01307.x. PMID 10806391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kurz M, Brachvogel V, Matter H, et al. (2003). "Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures". Proteins. 50 (2): 312–328. doi:10.1002/prot.10289. PMID 12486725.
Barley NF, Taylor V, Shaw-Smith CJ, et al. (2004). "Human ileal bile acid-binding protein promoter and the effects of CDX2". Biochim. Biophys. Acta. 1630 (2–3): 138–143. doi:10.1016/j.bbaexp.2003.09.008. PMID 14654244.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Landrier JF, Thomas C, Grober J, et al. (2005). "The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors". Biochim. Biophys. Acta. 1735 (1): 41–49. doi:10.1016/j.bbalip.2005.05.002. PMID 15936983.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
Bergheim I, Harsch S, Mueller O, et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers". J. Lipid Res. 47 (1): 42–50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Ohmachi T, Inoue H, Mimori K, et al. (2007). "Fatty acid binding protein 6 is overexpressed in colorectal cancer". Clin. Cancer Res. 12 (17): 5090–5095. doi:10.1158/1078-0432.CCR-05-2045. PMID 16951225.
Fang C, Dean J, Smith JW (2007). "A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma". Cancer Res. 67 (19): 9039–9046. doi:10.1158/0008-5472.CAN-06-3690. PMID 17909007.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170231 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020405 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FABP6 fatty acid binding protein 6, ileal (gastrotropin)".

[1]

[2]

[3]

[4]

[5]

@@ Line 3: / Line 3: @@
 == Function ==
 This gene encodes the [[ileum|ileal]] [[fatty acid binding protein]]. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain [[fatty acid]]s and other hydrophobic ligands. FABP6 and [[FABP1]] (the liver fatty acid binding protein) are also able to bind [[bile acid]]s. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene.<ref name="entrez"/>
@@ Line 12: / Line 11: @@
 {{refbegin | 2}}
 *{{cite journal  | vauthors=Börchers T, Hohoff C, Buhlmann C, Spener F |title=Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=57 |issue= 1 |pages= 77–84 |year= 1997 |pmid= 9250612 |doi=10.1016/S0952-3278(97)90496-8  }}
-*{{cite journal  | vauthors=Fujita M, Fujii H, Kanda T |title=Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. |journal=Eur. J. Biochem. |volume=233 |issue= 2 |pages= 406–13 |year= 1995 |pmid= 7588781 |doi=10.1111/j.1432-1033.1995.406_2.x  |display-authors=etal}}
+*{{cite journal  | vauthors=Fujita M, Fujii H, Kanda T |title=Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. |journal=Eur. J. Biochem. |volume=233 |issue= 2 |pages= 406–413 |year= 1995 |pmid= 7588781 |doi=10.1111/j.1432-1033.1995.406_2.x  |display-authors=etal}}
 *{{cite journal  | vauthors=Oelkers P, Dawson PA |title=Cloning and chromosomal localization of the human ileal lipid-binding protein. |journal=Biochim. Biophys. Acta |volume=1257 |issue= 2 |pages= 199–202 |year= 1995 |pmid= 7619861 |doi=  10.1016/0005-2760(95)00098-w}}
-*{{cite journal  | vauthors=Birkenmeier EH, Rowe LB, Crossman MW, Gordon JI |title=Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11. |journal=Mamm. Genome |volume=5 |issue= 12 |pages= 805–6 |year= 1995 |pmid= 7894165 |doi=10.1007/BF00292019  }}
+*{{cite journal  | vauthors=Birkenmeier EH, Rowe LB, Crossman MW, Gordon JI |title=Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11. |journal=Mamm. Genome |volume=5 |issue= 12 |pages= 805–806 |year= 1995 |pmid= 7894165 |doi=10.1007/BF00292019  }}
-*{{cite journal  | vauthors=Watanabe K, Hoshi N, Tsuura Y |title=Immunohistochemical distribution of intestinal 15 kDa protein in human tissues. |journal=Arch. Histol. Cytol. |volume=58 |issue= 3 |pages= 303–6 |year= 1996 |pmid= 8527237 |doi=10.1679/aohc.58.303  |display-authors=etal}}
+*{{cite journal  | vauthors=Watanabe K, Hoshi N, Tsuura Y |title=Immunohistochemical distribution of intestinal 15 kDa protein in human tissues. |journal=Arch. Histol. Cytol. |volume=58 |issue= 3 |pages= 303–306 |year= 1996 |pmid= 8527237 |doi=10.1679/aohc.58.303  |display-authors=etal}}
 *{{cite journal  | vauthors=Lücke C, Zhang F, Rüterjans H |title=Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein. |journal=Structure |volume=4 |issue= 7 |pages= 785–800 |year= 1997 |pmid= 8805562 |doi=10.1016/S0969-2126(96)00086-X  |display-authors=etal}}
-*{{cite journal  | vauthors=Grober J, Zaghini I, Fujii H |title=Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 29749–54 |year= 1999 |pmid= 10514450 |doi=10.1074/jbc.274.42.29749  |display-authors=etal}}
+*{{cite journal  | vauthors=Grober J, Zaghini I, Fujii H |title=Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 29749–29754 |year= 1999 |pmid= 10514450 |doi=10.1074/jbc.274.42.29749  |display-authors=etal}}
-*{{cite journal  | vauthors=Seibert C, Harteneck C, Ernst OP |title=Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells. |journal=Eur. J. Biochem. |volume=266 |issue= 3 |pages= 911–6 |year= 2000 |pmid= 10583385 |doi=10.1046/j.1432-1327.1999.00927.x  |display-authors=etal}}
+*{{cite journal  | vauthors=Seibert C, Harteneck C, Ernst OP |title=Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells. |journal=Eur. J. Biochem. |volume=266 |issue= 3 |pages= 911–916 |year= 2000 |pmid= 10583385 |doi=10.1046/j.1432-1327.1999.00927.x  |display-authors=etal}}
-*{{cite journal  | vauthors=Lücke C, Zhang F, Hamilton JA |title=Solution structure of ileal lipid binding protein in complex with glycocholate. |journal=Eur. J. Biochem. |volume=267 |issue= 10 |pages= 2929–38 |year= 2000 |pmid= 10806391 |doi=10.1046/j.1432-1327.2000.01307.x  |display-authors=etal}}
+*{{cite journal  | vauthors=Lücke C, Zhang F, Hamilton JA |title=Solution structure of ileal lipid binding protein in complex with glycocholate. |journal=Eur. J. Biochem. |volume=267 |issue= 10 |pages= 2929–2938 |year= 2000 |pmid= 10806391 |doi=10.1046/j.1432-1327.2000.01307.x  |display-authors=etal}}
-*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | vauthors=Kurz M, Brachvogel V, Matter H |title=Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures |journal=Proteins |volume=50 |issue= 2 |pages= 312–28 |year= 2003 |pmid= 12486725 |doi= 10.1002/prot.10289 |display-authors=etal}}
+*{{cite journal  | vauthors=Kurz M, Brachvogel V, Matter H |title=Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures |journal=Proteins |volume=50 |issue= 2 |pages= 312–328 |year= 2003 |pmid= 12486725 |doi= 10.1002/prot.10289 |display-authors=etal}}
-*{{cite journal  | vauthors=Barley NF, Taylor V, Shaw-Smith CJ |title=Human ileal bile acid-binding protein promoter and the effects of CDX2 |journal=Biochim. Biophys. Acta |volume=1630 |issue= 2–3 |pages= 138–43 |year= 2004 |pmid= 14654244 |doi=  10.1016/j.bbaexp.2003.09.008|display-authors=etal}}
+*{{cite journal  | vauthors=Barley NF, Taylor V, Shaw-Smith CJ |title=Human ileal bile acid-binding protein promoter and the effects of CDX2 |journal=Biochim. Biophys. Acta |volume=1630 |issue= 2–3 |pages= 138–143 |year= 2004 |pmid= 14654244 |doi=  10.1016/j.bbaexp.2003.09.008|display-authors=etal}}
-*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
+*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | vauthors=Landrier JF, Thomas C, Grober J |title=The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors |journal=Biochim. Biophys. Acta |volume=1735 |issue= 1 |pages= 41–9 |year= 2005 |pmid= 15936983 |doi= 10.1016/j.bbalip.2005.05.002 |display-authors=etal}}
+*{{cite journal  | vauthors=Landrier JF, Thomas C, Grober J |title=The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors |journal=Biochim. Biophys. Acta |volume=1735 |issue= 1 |pages= 41–49 |year= 2005 |pmid= 15936983 |doi= 10.1016/j.bbalip.2005.05.002 |display-authors=etal}}
-*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
+*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–1178 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
 *{{cite journal  | vauthors=Bergheim I, Harsch S, Mueller O |title=Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers |journal=J. Lipid Res. |volume=47 |issue= 1 |pages= 42–50 |year= 2006 |pmid= 16237211 |doi= 10.1194/jlr.M500215-JLR200 |display-authors=etal}}
-*{{cite journal  | vauthors=Ohmachi T, Inoue H, Mimori K |title=Fatty acid binding protein 6 is overexpressed in colorectal cancer |journal=Clin. Cancer Res. |volume=12 |issue= 17 |pages= 5090–5 |year= 2007 |pmid= 16951225 |doi= 10.1158/1078-0432.CCR-05-2045 |display-authors=etal}}
+*{{cite journal  | vauthors=Ohmachi T, Inoue H, Mimori K |title=Fatty acid binding protein 6 is overexpressed in colorectal cancer |journal=Clin. Cancer Res. |volume=12 |issue= 17 |pages= 5090–5095 |year= 2007 |pmid= 16951225 |doi= 10.1158/1078-0432.CCR-05-2045 |display-authors=etal}}
-*{{cite journal  | vauthors=Fang C, Dean J, Smith JW |title=A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma |journal=Cancer Res. |volume=67 |issue= 19 |pages= 9039–46 |year= 2007 |pmid= 17909007 |doi= 10.1158/0008-5472.CAN-06-3690 }}
+*{{cite journal  | vauthors=Fang C, Dean J, Smith JW |title=A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma |journal=Cancer Res. |volume=67 |issue= 19 |pages= 9039–9046 |year= 2007 |pmid= 17909007 |doi= 10.1158/0008-5472.CAN-06-3690 }}
 {{refend}}
 {{PDB Gallery|geneid=2172}}
 {{Carrier proteins}}
 {{gene-5-stub}}

v t e Proteins: carrier proteins
Fatty acid	FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7
Hormone	peptide hormone: Follistatin Growth hormone binding protein Insulin-like growth factor binding protein IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Neurophysins Neurophysin I II steroid hormone: Sex hormone binding globulin/Androgen binding protein Transcortin Thyroxine-binding globulin Transthyretin
Metal/element	calcium Calcium-binding protein Calmodulin-binding proteins copper Ceruloplasmin iron Iron-binding proteins Transferrin receptor
Vitamin	Retinol binding protein 1 2 3 4 Transcobalamin
Pigment	Plant Light-Harvesting Complex Orange Carotenoid Protein Phycobiliprotein Photosynthetic Reaction Centers Phytochrome Rhodopsin
Other	Acyl carrier protein Adaptor protein Cholesterylester transfer protein F-box protein GTP-binding protein Latent TGF-beta binding protein Major urinary proteins Membrane transport protein Odorant binding protein

Revision as of 21:49, 26 August 2019

Function

References

Further reading