Vesiculo-vacuolar organelle: Difference between revisions

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A vesiculo-vacuolar organelle (VVO) is an organelle that contributes to endothelial cell permeability. VVOs are found in the endothelium of normal blood vessels and vessels associated with tumors or allergic inflammation.^[1]

VVOs actively transport fluid and macromolecules from the cytoplasm of endothelial cells into the blood vessel lumen, contributing to the increase in vascular permeability that occurs during the process of inflammation. This kind of transport is mediated by VEGF, one of the chemical mediators of inflammation.^[1]

References

^ ^a ^b Dvorak, AM; Feng, D (April 2001). "The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle". Journal of Histochemistry and Cytochemistry. 49 (4): 419–32. PMID 11259444.

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[dvorak1-1] Dvorak, AM; Feng, D (April 2001). "The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle". Journal of Histochemistry and Cytochemistry. 49 (4): 419–32. PMID 11259444.

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	A '''vesiculo-vacuolar organelle''' (VVO) is an [[organelle]] that contributes to [[endothelial cells\|endothelial cell]] permeability. VVOs are found in the endothelium of normal [[blood vessel]]s and vessels associated with [[tumor]]s or [[allergic inflammation]].<ref name="dvorak1">{{cite journal\|last1=Dvorak\|first1=AM\|last2=Feng\|first2=D\|title=The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle.\|journal=Journal of Histochemistry and Cytochemistry\|date=April 2001\|volume=49\|issue=4\|pages=419–32\|pmid=11259444}}</ref>		A '''vesiculo-vacuolar organelle''' (VVO) is an [[organelle]] that contributes to [[endothelial cells\|endothelial cell]] permeability. VVOs are found in the endothelium of normal [[blood vessel]]s and vessels associated with [[tumor]]s or [[allergic inflammation]].<ref name="dvorak1">{{cite journal\|last1=Dvorak\|first1=AM\|last2=Feng\|first2=D\|title=The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle.\|journal=Journal of Histochemistry and Cytochemistry\|date=April 2001\|volume=49\|issue=4\|pages=419–32\|pmid=11259444}}</ref>