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''NtrC'' is the name of the protein necessary for the procaryotic regulon transcription factor sigma N (sigma 54) to form an open complex with RNA polymerase in order to activate glnA transcription. The open --> closed conformational change of the sigmaN-RNA polymerase complex around the glutamine synthetase gene promoter requires ATP and involves the 180 degree turn of the DNA so that the NtrC protein (bound to two -140 and -108 upstream enhancer regions) may interact directly with the promoter-bound sigma N-RNA polymerase complex. |
''NtrC'' is the name of the protein necessary for the procaryotic regulon transcription factor sigma N (sigma 54) to form an open complex with RNA polymerase in order to activate glnA transcription. The open --> closed conformational change of the sigmaN-RNA polymerase complex around the glutamine synthetase gene promoter requires ATP and involves the 180 degree turn of the DNA so that the NtrC protein (bound to two -140 and -108 upstream enhancer regions) may interact directly with the promoter-bound sigma N-RNA polymerase complex. |
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== References == |
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Lecture notes, ''Molecular Genetics 3'' at Edinburgh University autumn 2006 |
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Revision as of 04:42, 8 December 2006
NtrC is the name of the protein necessary for the procaryotic regulon transcription factor sigma N (sigma 54) to form an open complex with RNA polymerase in order to activate glnA transcription. The open --> closed conformational change of the sigmaN-RNA polymerase complex around the glutamine synthetase gene promoter requires ATP and involves the 180 degree turn of the DNA so that the NtrC protein (bound to two -140 and -108 upstream enhancer regions) may interact directly with the promoter-bound sigma N-RNA polymerase complex.
References
Lecture notes, Molecular Genetics 3 at Edinburgh University autumn 2006