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'''Estradiol undecylate/norethisterone enanthate''' ('''EU/NETE''') is a [[combination drug|combination medication]] of [[estradiol undecylate]] (EU), an [[estrogen (medication)|estrogen]], and [[norethisterone enanthate]] (NETE), a [[progestin]], which was developed by [[Schering AG|Schering]] for potential use as a [[combined injectable contraceptive]] in women but was ultimately never marketed.<ref name="pmid5563241">{{cite journal | vauthors = Karim M, el-Mahgoub S | title = Conception control by cyclic injections of norethisterone enanthate and estradiol unducelate | journal = Am. J. Obstet. Gynecol. | volume = 110 | issue = 5 | pages = 740–2 | date = July 1971 | pmid = 5563241 | doi = 10.1016/0002-9378(71)90268-7 | url = }}</ref><ref name="pmid8013216">{{cite journal | vauthors = Toppozada MK | title = Existing once-a-month combined injectable contraceptives | journal = Contraception | volume = 49 | issue = 4 | pages = 293–301 | year = 1994 | pmid = 8013216 | doi = 10.1016/0010-7824(94)90029-9 | url = }}</ref><ref name="GoldsmithToppozada1983">Goldsmith, A., & Toppozada, M. (1983). Long-acting contraception. pp. 94-95 https://www.popline.org/node/423289</ref><ref name="pmid865726">{{cite journal | vauthors = Toppozada M | title = The clinical use of monthly injectable contraceptive preparations | journal = Obstet Gynecol Surv | volume = 32 | issue = 6 | pages = 335–47 | date = June 1977 | pmid = 865726 | doi = 10.1097/00006254-197706000-00001 | url = }}</ref><ref name="Kadam2007">{{cite book|author=Dr. S. S. Kadam|title=Principles of Medicinal Chemistry Volume 2|url=https://books.google.com/books?id=Z7Pb3lJuRksC&pg=PA381|date=July 2007|publisher=Pragati Books Pvt. Ltd.|isbn=978-81-85790-03-9|pages=381–}}</ref><ref name="pmid12290848">{{cite journal | vauthors = Newton JR, D'arcangues C, Hall PE | title = A review of "once-a-month" combined injectable contraceptives | journal = J Obstet Gynaecol (Lahore) | volume = 4 Suppl 1 | issue = | pages = S1–34 | year = 1994 | pmid = 12290848 | doi = 10.3109/01443619409027641| url = }}</ref> It contained 5 to 10&nbsp;mg EU and 50 to 70&nbsp;mg NETE in [[oil solution]] and was intended for use by [[intramuscular injection]] at regular intervals.<ref name="pmid5563241" /><ref name="pmid8013216" /><ref name="GoldsmithToppozada1983" /><ref name="pmid865726" /><ref name="Kadam2007" /><ref name="pmid12290848" /> Although never commercialized, EU/NETE was found to be effective and well-tolerated.<ref name="pmid5563241" /><ref name="pmid8013216" /><ref name="GoldsmithToppozada1983" /><ref name="pmid865726" /><ref name="Kadam2007" /><ref name="pmid12290848" />
'''Estradiol undecylate/norethisterone enanthate''' ('''EU/NETE''') is a [[combination drug|combination medication]] of [[estradiol undecylate]] (EU), an [[estrogen (medication)|estrogen]], and [[norethisterone enanthate]] (NETE), a [[progestin]], which was developed by [[Schering AG|Schering]] for potential use as a [[combined injectable contraceptive]] in women but was ultimately never marketed.<ref name="pmid5563241">{{cite journal | vauthors = Karim M, el-Mahgoub S | title = Conception control by cyclic injections of norethisterone enanthate and estradiol unducelate | journal = Am. J. Obstet. Gynecol. | volume = 110 | issue = 5 | pages = 740–2 | date = July 1971 | pmid = 5563241 | doi = 10.1016/0002-9378(71)90268-7 | url = }}</ref><ref name="pmid8013216">{{cite journal | vauthors = Toppozada MK | title = Existing once-a-month combined injectable contraceptives | journal = Contraception | volume = 49 | issue = 4 | pages = 293–301 | year = 1994 | pmid = 8013216 | doi = 10.1016/0010-7824(94)90029-9 | url = }}</ref><ref name="GoldsmithToppozada1983">Goldsmith, A., & Toppozada, M. (1983). Long-acting contraception. pp. 94-95 https://www.popline.org/node/423289 {{Webarchive|url=https://web.archive.org/web/20190324131844/https://www.popline.org/node/423289 |date=2019-03-24 }}</ref><ref name="pmid865726">{{cite journal | vauthors = Toppozada M | title = The clinical use of monthly injectable contraceptive preparations | journal = Obstet Gynecol Surv | volume = 32 | issue = 6 | pages = 335–47 | date = June 1977 | pmid = 865726 | doi = 10.1097/00006254-197706000-00001 | url = }}</ref><ref name="Kadam2007">{{cite book|author=Dr. S. S. Kadam|title=Principles of Medicinal Chemistry Volume 2|url=https://books.google.com/books?id=Z7Pb3lJuRksC&pg=PA381|date=July 2007|publisher=Pragati Books Pvt. Ltd.|isbn=978-81-85790-03-9|pages=381–}}</ref><ref name="pmid12290848">{{cite journal | vauthors = Newton JR, D'arcangues C, Hall PE | title = A review of "once-a-month" combined injectable contraceptives | journal = J Obstet Gynaecol (Lahore) | volume = 4 Suppl 1 | issue = | pages = S1–34 | year = 1994 | pmid = 12290848 | doi = 10.3109/01443619409027641| url = }}</ref> It contained 5 to 10&nbsp;mg EU and 50 to 70&nbsp;mg NETE in [[oil solution]] and was intended for use by [[intramuscular injection]] at regular intervals.<ref name="pmid5563241" /><ref name="pmid8013216" /><ref name="GoldsmithToppozada1983" /><ref name="pmid865726" /><ref name="Kadam2007" /><ref name="pmid12290848" /> Although never commercialized, EU/NETE was found to be effective and well-tolerated.<ref name="pmid5563241" /><ref name="pmid8013216" /><ref name="GoldsmithToppozada1983" /><ref name="pmid865726" /><ref name="Kadam2007" /><ref name="pmid12290848" />


==See also==
==See also==

Revision as of 23:50, 10 December 2019

Estradiol undecylate /
norethisterone enanthate
Estradiol undecylate (top) and
norethisterone enanthate (bottom)
Combination of
Estradiol undecylateEstrogen
Norethisterone enanthateProgestogen
Clinical data
Other namesEU/NETE
Routes of
administration		Intramuscular injection

Estradiol undecylate/norethisterone enanthate (EU/NETE) is a combination medication of estradiol undecylate (EU), an estrogen, and norethisterone enanthate (NETE), a progestin, which was developed by Schering for potential use as a combined injectable contraceptive in women but was ultimately never marketed.[1][2][3][4][5][6] It contained 5 to 10 mg EU and 50 to 70 mg NETE in oil solution and was intended for use by intramuscular injection at regular intervals.[1][2][3][4][5][6] Although never commercialized, EU/NETE was found to be effective and well-tolerated.[1][2][3][4][5][6]

See also

References

  1. ^ a b c Karim M, el-Mahgoub S (July 1971). "Conception control by cyclic injections of norethisterone enanthate and estradiol unducelate". Am. J. Obstet. Gynecol. 110 (5): 740–2. doi:10.1016/0002-9378(71)90268-7. PMID 5563241.
  2. ^ a b c Toppozada MK (1994). "Existing once-a-month combined injectable contraceptives". Contraception. 49 (4): 293–301. doi:10.1016/0010-7824(94)90029-9. PMID 8013216.
  3. ^ a b c Goldsmith, A., & Toppozada, M. (1983). Long-acting contraception. pp. 94-95 https://www.popline.org/node/423289 Archived 2019-03-24 at the Wayback Machine
  4. ^ a b c Toppozada M (June 1977). "The clinical use of monthly injectable contraceptive preparations". Obstet Gynecol Surv. 32 (6): 335–47. doi:10.1097/00006254-197706000-00001. PMID 865726.
  5. ^ a b c Dr. S. S. Kadam (July 2007). Principles of Medicinal Chemistry Volume 2. Pragati Books Pvt. Ltd. pp. 381–. ISBN 978-81-85790-03-9.
  6. ^ a b c Newton JR, D'arcangues C, Hall PE (1994). "A review of "once-a-month" combined injectable contraceptives". J Obstet Gynaecol (Lahore). 4 Suppl 1: S1–34. doi:10.3109/01443619409027641. PMID 12290848.



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