User:Immcarle103/sandbox: Difference between revisions
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Immcarle103 (talk | contribs) Bibliography and reference |
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reference for IL-24 |
reference for IL-24 |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926403/ |
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https://www.sciencedirect.com/topics/neuroscience/interleukin-24 |
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https://www.nature.com/articles/ni.2664 |
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IL-24 functions as a cytokine (at low concentrations). Its normal physiological role is connected with wound healing (In normal skin cells, it suppress keratinocyte proliferation during wound healing[13]), protection against diseases caused by bacteria (for example Mycobacterim tuberculosis, Salmonella typhimurium, Pseudomonas aeruginosa). It is also important in autoimmune diseases such as psoriasis, rheumatoid arthritis or spondyloarthropathy. |
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IL-24 carries its functions through two types of membrane receptors (IL-22R1/IL-20R2 and IL-20R1/IL-20R2) with simultaneous activation of the JAK/signal transducer and activator of transcription (STAT) pathway within their cytoplasmic domains.<ref>{{Cite journal|last=Wang|first=Mai|last2=Tan|first2=Zhongjia|last3=Zhang|first3=Rong|last4=Kotenko|first4=Sergei V.|last5=Liang|first5=Peng|date=2002-03-01|title=Interleukin 24 (MDA-7/MOB-5) Signals through Two Heterodimeric Receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2|url=http://www.jbc.org/content/277/9/7341|journal=Journal of Biological Chemistry|language=en|volume=277|issue=9|pages=7341–7347|doi=10.1074/jbc.M106043200|issn=0021-9258|pmid=11706020}}</ref> |
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Although it belongs to the same group of cytokines as IL-10, it has different effect on the immune system. IL-10 is suppressive cytokine and suppresses inflammation but IL-24 has immunomodulatory function. |
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Beside the normal physiological roles, at supra-physiological levels, IL-24 inhibits tumor growth, invasion, metastasis and angiogenesis.[14] |
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Revision as of 04:22, 3 February 2020
<User: Immcarle103
reference for IL-24
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926403/
https://www.sciencedirect.com/topics/neuroscience/interleukin-24
https://www.nature.com/articles/ni.2664
IL-24 functions as a cytokine (at low concentrations). Its normal physiological role is connected with wound healing (In normal skin cells, it suppress keratinocyte proliferation during wound healing[13]), protection against diseases caused by bacteria (for example Mycobacterim tuberculosis, Salmonella typhimurium, Pseudomonas aeruginosa). It is also important in autoimmune diseases such as psoriasis, rheumatoid arthritis or spondyloarthropathy.
IL-24 carries its functions through two types of membrane receptors (IL-22R1/IL-20R2 and IL-20R1/IL-20R2) with simultaneous activation of the JAK/signal transducer and activator of transcription (STAT) pathway within their cytoplasmic domains.[1]
Although it belongs to the same group of cytokines as IL-10, it has different effect on the immune system. IL-10 is suppressive cytokine and suppresses inflammation but IL-24 has immunomodulatory function.
Beside the normal physiological roles, at supra-physiological levels, IL-24 inhibits tumor growth, invasion, metastasis and angiogenesis.[14]
- ^ Wang, Mai; Tan, Zhongjia; Zhang, Rong; Kotenko, Sergei V.; Liang, Peng (2002-03-01). "Interleukin 24 (MDA-7/MOB-5) Signals through Two Heterodimeric Receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2". Journal of Biological Chemistry. 277 (9): 7341–7347. doi:10.1074/jbc.M106043200. ISSN 0021-9258. PMID 11706020.
{{cite journal}}: CS1 maint: unflagged free DOI (link)