Small nucleolar RNA SNORD111: Difference between revisions
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'''Small Nucleolar RNA SNORD111''' (also known as HBII-82) is a [[non-coding RNA]] (ncRNA) molecule which functions in the biogenesis (modification) of other [[small nuclear RNA]]s (snRNAs). This type of modifying RNA is located in the [[nucleolus]] of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a [[snoRNA|small nucleolar RNA]] (snoRNA) and also often referred to as a guide RNA. |
'''Small Nucleolar RNA SNORD111''' (also known as HBII-82) is a [[non-coding RNA]] (ncRNA) molecule which functions in the biogenesis (modification) of other [[small nuclear RNA]]s (snRNAs). This type of modifying RNA is located in the [[nucleolus]] of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a [[snoRNA|small nucleolar RNA]] (snoRNA) and also often referred to as a guide RNA. |
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SNORD111 belongs to the [[SnoRNA#C |
SNORD111 belongs to the [[SnoRNA#C/D box|C/D box]] class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2′-O-[[methylation]] of substrate RNAs.<ref>{{cite journal | vauthors = Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | title = Purified box C/D snoRNPs are able to reproduce site-specific 2′-O-methylation of target RNA in vitro | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = 6663–6668 | date = October 2002 | pmid = 12215523 | pmc = 134041 | doi = 10.1128/MCB.22.19.6663-6668.2002 }}</ref> |
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SNORD111 is predicted to guide the |
SNORD111 is predicted to guide the 2′O-ribose methylation of 28S [[ribosomal RNA]] (rRNA) at residue G3923.<ref>{{cite journal | vauthors = Lestrade L, Weber MJ | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D158–162 | date = January 2006 | pmid = 16381836 | pmc = 1347365 | doi = 10.1093/nar/gkj002 | citeseerx = 10.1.1.105.7552 }}</ref><ref name="pmid11387227">{{cite journal | vauthors = Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J | title = RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse | journal = The EMBO Journal | volume = 20 | issue = 11 | pages = 2943–2953 | date = June 2001 | pmid = 11387227 | pmc = 125495 | doi = 10.1093/emboj/20.11.2943 }}</ref> |
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The exact role of these molecules, however, is not currently known. |
The exact role of these molecules, however, is not currently known. |
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Revision as of 21:05, 22 February 2020
| Small Nucleolar RNA SNORD111 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORD111 | |
| Identifiers | |
| Symbol | SNORD111 |
| Rfam | RF00611 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; C/D-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000593 |
| PDB structures | PDBe |
Small Nucleolar RNA SNORD111 (also known as HBII-82) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
SNORD111 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2′-O-methylation of substrate RNAs.[1]
SNORD111 is predicted to guide the 2′O-ribose methylation of 28S ribosomal RNA (rRNA) at residue G3923.[2][3]
The exact role of these molecules, however, is not currently known.
References
- ^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2′-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
- ^ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158–162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
- ^ Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
External links
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