Angiosarcoma: Difference between revisions
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Angiosarcomas show signs of [[hemorrhage]] and [[necrosis]]. Pathologically, tumor cells show increased nuclear to cytoplasm ratio, nuclear hyperchromasia, nuclear pleomorphism and high mitotic activity.<ref>{{cite book |editor1-first=Vinay |editor1-last=Kumar |editor2-first=Abul K. |editor2-last=Abbas |editor3-first=Jon C. |editor3-last=Aster |title=Robbins Basic Pathology |date=2013|publisher=Elsevier/Saunders|location=Philadelphia |isbn=9781437717815|edition=9th}}</ref> |
Angiosarcomas show signs of [[hemorrhage]] and [[necrosis]]. Pathologically, tumor cells show increased nuclear to cytoplasm ratio, nuclear hyperchromasia, nuclear pleomorphism and high mitotic activity.<ref>{{cite book |editor1-first=Vinay |editor1-last=Kumar |editor2-first=Abul K. |editor2-last=Abbas |editor3-first=Jon C. |editor3-last=Aster |title=Robbins Basic Pathology |date=2013|publisher=Elsevier/Saunders|location=Philadelphia |isbn=9781437717815|edition=9th}}</ref> |
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In humans, angiosarcomas and lymphangiosarcomas of the skin are uncommon. |
In humans, angiosarcomas and lymphangiosarcomas of the skin are uncommon. However, recent study has identified ultraviolet light from the sun as being linked to the onset of cutaneous angiosarcoma. <ref>https://www.nature.com/articles/s41591-019-0749-z</ref>. {{Citation needed|date=March 2011}} Angiosarcoma of the liver, a rare fatal tumor, has been seen in workers intensively exposed to the gas [[Vinyl chloride|vinyl chloride monomer]] (VCM) for prolonged periods while working in [[polyvinyl chloride]] (PVC) polymerization plants. It has also been associated with individuals exposed to [[arsenic]]-containing insecticides and [[Thorotrast]].{{citation needed|date=May 2017}} In dogs, hemangiosarcoma is relatively common, with the [[golden retriever]] and [[Labrador retriever]] at higher risk of the disease than other breeds.<ref name="Gustafson 2018">{{cite journal |last1=Gustafson |first1=Daniel L. |last2=Duval |first2=Dawn L. |last3=Regan |first3=Daniel P. |last4=Thamm |first4=Douglas H. |title=Canine sarcomas as a surrogate for the human disease |journal=Pharmacology & Therapeutics |date=August 2018 |volume=188 |pages=80–96 |doi=10.1016/j.pharmthera.2018.01.012 |pmid=29378221 |pmc=6432917}}</ref> |
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==See also== |
==See also== |
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Revision as of 14:20, 10 March 2020
| Angiosarcoma | |
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| Micrograph of an angiosarcoma. H&E stain. | |
| Specialty | Oncology  |
Angiosarcoma is a cancer of the endothelial cells that line the walls of blood vessels or lymphatic vessels. Most tumors of visceral blood and lymphatic vessel walls are cancerous (malignant).[citation needed] Because these cancers are carried by the blood flow or lymphatic flow, they can more easily metastasize to distant sites, particularly the liver and lungs.
Angiosarcomas show signs of hemorrhage and necrosis. Pathologically, tumor cells show increased nuclear to cytoplasm ratio, nuclear hyperchromasia, nuclear pleomorphism and high mitotic activity.[1]
In humans, angiosarcomas and lymphangiosarcomas of the skin are uncommon. However, recent study has identified ultraviolet light from the sun as being linked to the onset of cutaneous angiosarcoma. [2]. [citation needed] Angiosarcoma of the liver, a rare fatal tumor, has been seen in workers intensively exposed to the gas vinyl chloride monomer (VCM) for prolonged periods while working in polyvinyl chloride (PVC) polymerization plants. It has also been associated with individuals exposed to arsenic-containing insecticides and Thorotrast.[citation needed] In dogs, hemangiosarcoma is relatively common, with the golden retriever and Labrador retriever at higher risk of the disease than other breeds.[3]
See also
- Glomangiosarcoma
- Kaposi's sarcoma, a different type of cancer that also involves endothelial-type cells
- List of cutaneous conditions
- Stewart–Treves syndrome
References
- ^ Kumar, Vinay; Abbas, Abul K.; Aster, Jon C., eds. (2013). Robbins Basic Pathology (9th ed.). Philadelphia: Elsevier/Saunders. ISBN 9781437717815.
- ^ https://www.nature.com/articles/s41591-019-0749-z
- ^ Gustafson, Daniel L.; Duval, Dawn L.; Regan, Daniel P.; Thamm, Douglas H. (August 2018). "Canine sarcomas as a surrogate for the human disease". Pharmacology & Therapeutics. 188: 80–96. doi:10.1016/j.pharmthera.2018.01.012. PMC 6432917. PMID 29378221.