Pleomorphism (cytology): Difference between revisions
Content deleted Content added
No edit summary Tags: Mobile edit Mobile web edit |
No edit summary Tags: Mobile edit Mobile web edit |
||
| Line 2: | Line 2: | ||
[[Image:Serous carcinoma 2a - cytology.jpg|right|thumb|200px|A [[micrograph]] showing cells with marked nuclear shape and size variation, a component of nuclear ''pleomorphism''.]] |
[[Image:Serous carcinoma 2a - cytology.jpg|right|thumb|200px|A [[micrograph]] showing cells with marked nuclear shape and size variation, a component of nuclear ''pleomorphism''.]] |
||
'''Pleomorphism''' is a term used in hu hu hu [[histology]] and [[cytopathology]] to describe variability in the size, shape and [[staining]] of [[cell (biology)|cell]]s and/or their [[cell nucleus|nuclei]]. Several key determinants of cell and nuclear size, like [[ploidy]] and the regulation of cellular [[metabolism]], are commonly disrupted in [[tumors]].<ref name=Schmoller2015>{{cite journal |last1=Schmoller |first1=Kurt M. |last2=Skotheim |first2=Jan M.|title=The Biosynthetic Basis of Cell Size Control |journal=Trends Cell Biol.|date=December 2015 |volume=25 |issue=12 |pages=793-802|doi=10.1016/j.tcb.2015.10.006|pmid=26573465}}</ref> Therefore, cellular and nuclear pleomorphism is one of the earliest hallmarks of [[cancer]] progression and a feature characteristic of [[malignant neoplasms]] and dysplasia.<ref name=Travis2015>{{cite book|last1=Travis|first1=W.D.|last2=Brambilla|first2=B.|last3=Burke|first3=A.P|last4=Marx |first4=A.|last5=Nicholson|first5=A.G.|title=WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart|url=https://apps.who.int/bookorders/anglais/detart1.jsp?codlan=1&codcol=70&codcch=4007|location= Lyon|publisher=International Agency for Research on Cancer|isbn=978-92-832-2436-5}}</ref><ref name=El-Naggar2017>{{cite book|last1=El-Naggar|first1=A.K.|last2=Chan|first2=J.C.K.|last3=Grandis|first3=J.R.|last4=Takata |first4=T.|last5=Slootweg|first5=P.J.|title=WHO Classification of Head and Neck Tumours|url=http://publications.iarc.fr/Book-And-Report-Series/Who-Iarc-Classification-Of-Tumours/Who-Classification-Of-Head-And-Neck-Tumours-2017|location= Lyon|publisher=International Agency for Research on Cancer|isbn=978-92-832-2438-9}}</ref> Certain [[benign]] cell types may also exhibit pleomorphism, e.g. [[neuroendocrine cell]]s, [[Arias-Stella reaction]]. |
'''Pleomorphism''' is a term used in hu hu hu [[histology]] and [[cytopathology]] হাকুড় পাকুড় শিকিলাকা to describe variability in the size, shape and [[staining]] of [[cell (biology)|cell]]s and/or their [[cell nucleus|nuclei]]. Several key determinants of cell and nuclear size, like [[ploidy]] and the regulation of cellular [[metabolism]], are commonly disrupted in [[tumors]].<ref name=Schmoller2015>{{cite journal |last1=Schmoller |first1=Kurt M. |last2=Skotheim |first2=Jan M.|title=The Biosynthetic Basis of Cell Size Control |journal=Trends Cell Biol.|date=December 2015 |volume=25 |issue=12 |pages=793-802|doi=10.1016/j.tcb.2015.10.006|pmid=26573465}}</ref> Therefore, cellular and nuclear pleomorphism is one of the earliest hallmarks of [[cancer]] progression and a feature characteristic of [[malignant neoplasms]] and dysplasia.<ref name=Travis2015>{{cite book|last1=Travis|first1=W.D.|last2=Brambilla|first2=B.|last3=Burke|first3=A.P|last4=Marx |first4=A.|last5=Nicholson|first5=A.G.|title=WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart|url=https://apps.who.int/bookorders/anglais/detart1.jsp?codlan=1&codcol=70&codcch=4007|location= Lyon|publisher=International Agency for Research on Cancer|isbn=978-92-832-2436-5}}</ref><ref name=El-Naggar2017>{{cite book|last1=El-Naggar|first1=A.K.|last2=Chan|first2=J.C.K.|last3=Grandis|first3=J.R.|last4=Takata |first4=T.|last5=Slootweg|first5=P.J.|title=WHO Classification of Head and Neck Tumours|url=http://publications.iarc.fr/Book-And-Report-Series/Who-Iarc-Classification-Of-Tumours/Who-Classification-Of-Head-And-Neck-Tumours-2017|location= Lyon|publisher=International Agency for Research on Cancer|isbn=978-92-832-2438-9}}</ref> Certain [[benign]] cell types may also exhibit pleomorphism, e.g. [[neuroendocrine cell]]s, [[Arias-Stella reaction]]. |
||
Despite the prevalence of pleomorphism in human pathology, its role in disease progression is unclear. In [[epithelial]] [[Tissue (biology)|tissue]], pleomorphism in cellular size can induce packing defects and disperse aberrant cells.<ref name=Ramanathan2019>{{cite journal |last1=Ramanathan |first1=Subramanian P. |last2=Krajnc |first2=Matej |last3=Gibson |first3=Matthew C. |title=Cell-Size Pleomorphism Drives Aberrant Clone Dispersal in Proliferating Epithelia |journal=Developmental Cell |date=October 2019 |volume=51 |issue=1 |pages=49–61.e4 |doi=10.1016/j.devcel.2019.08.005 |pmid=31495693 }}</ref> But the consequence of atypical cell and nuclear morphology in other tissues is unknown. |
Despite the prevalence of pleomorphism in human pathology, its role in disease progression is unclear. In [[epithelial]] [[Tissue (biology)|tissue]], pleomorphism in cellular size can induce packing defects and disperse aberrant cells.<ref name=Ramanathan2019>{{cite journal |last1=Ramanathan |first1=Subramanian P. |last2=Krajnc |first2=Matej |last3=Gibson |first3=Matthew C. |title=Cell-Size Pleomorphism Drives Aberrant Clone Dispersal in Proliferating Epithelia |journal=Developmental Cell |date=October 2019 |volume=51 |issue=1 |pages=49–61.e4 |doi=10.1016/j.devcel.2019.08.005 |pmid=31495693 }}</ref> But the consequence of atypical cell and nuclear morphology in other tissues is unknown. |
||
Revision as of 02:43, 14 March 2020
Pleomorphism is a term used in hu hu hu histology and cytopathology হাকুড় পাকুড় শিকিলাকা to describe variability in the size, shape and staining of cells and/or their nuclei. Several key determinants of cell and nuclear size, like ploidy and the regulation of cellular metabolism, are commonly disrupted in tumors.[1] Therefore, cellular and nuclear pleomorphism is one of the earliest hallmarks of cancer progression and a feature characteristic of malignant neoplasms and dysplasia.[2][3] Certain benign cell types may also exhibit pleomorphism, e.g. neuroendocrine cells, Arias-Stella reaction.
Despite the prevalence of pleomorphism in human pathology, its role in disease progression is unclear. In epithelial tissue, pleomorphism in cellular size can induce packing defects and disperse aberrant cells.[4] But the consequence of atypical cell and nuclear morphology in other tissues is unknown.
See also
References
- ^ Schmoller, Kurt M.; Skotheim, Jan M. (December 2015). "The Biosynthetic Basis of Cell Size Control". Trends Cell Biol. 25 (12): 793–802. doi:10.1016/j.tcb.2015.10.006. PMID 26573465.
- ^ Travis, W.D.; Brambilla, B.; Burke, A.P; Marx, A.; Nicholson, A.G. WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart. Lyon: International Agency for Research on Cancer. ISBN 978-92-832-2436-5.
- ^ El-Naggar, A.K.; Chan, J.C.K.; Grandis, J.R.; Takata, T.; Slootweg, P.J. WHO Classification of Head and Neck Tumours. Lyon: International Agency for Research on Cancer. ISBN 978-92-832-2438-9.
- ^ Ramanathan, Subramanian P.; Krajnc, Matej; Gibson, Matthew C. (October 2019). "Cell-Size Pleomorphism Drives Aberrant Clone Dispersal in Proliferating Epithelia". Developmental Cell. 51 (1): 49–61.e4. doi:10.1016/j.devcel.2019.08.005. PMID 31495693.
_histopatholgy.jpg){kind=small} | This article related to pathology is a stub. You can help Wikipedia by expanding it. |