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{{Infobox_gene}}
{{Infobox_gene}}


'''Condensin-2 complex subunit G2''' (CAP-G2) also known as '''chromosome-associated protein G2''' (CAP-G2) or '''leucine zipper protein 5''' (LUZP5) is a [[protein]] that in humans is encoded by the ''NCAPG2'' [[gene]].<ref name="pmid14532007">{{cite journal | vauthors = Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T | title = Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells | journal = Cell | volume = 115 | issue = 1 | pages = 109–21 | date = October 2003 | pmid = 14532007 | pmc = | doi = 10.1016/S0092-8674(03)00724-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54892| access-date = }}</ref> CAP-G2 is a subunit of [[condensin]] II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis<ref>{{cite journal | vauthors = Kim JH, Shim J, Ji MJ, Jung Y, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee C, Lee BI, Kim KT | title = The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores | journal = Nature Communications | volume = 5 | pages = 4588 | date = August 2014 | pmid = 25109385 | doi = 10.1038/ncomms5588 }}</ref>
'''Condensin-2 complex subunit G2''' (CAP-G2) also known as '''chromosome-associated protein G2''' (CAP-G2) or '''leucine zipper protein 5''' (LUZP5) is a [[protein]] that in humans is encoded by the ''NCAPG2'' [[gene]].<ref name="pmid14532007">{{cite journal | vauthors = Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T | title = Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells | journal = Cell | volume = 115 | issue = 1 | pages = 109–21 | date = October 2003 | pmid = 14532007 | pmc = | doi = 10.1016/S0092-8674(03)00724-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54892| access-date = }}</ref> CAP-G2 is a subunit of [[condensin]] II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis<ref>{{cite journal | vauthors = Kim JH, Shim J, Ji MJ, Jung Y, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee C, Lee BI, Kim KT | title = The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores | journal = Nature Communications | volume = 5 | pages = 4588 | date = August 2014 | pmid = 25109385 | doi = 10.1038/ncomms5588 | bibcode = 2014NatCo...5.4588K }}</ref>


==Clinical importance==
==Clinical importance==
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{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD | title = More than blood, a novel gene required for mammalian postimplantation development | journal = Molecular and Cellular Biology | volume = 24 | issue = 3 | pages = 1168–73 | date = February 2004 | pmid = 14729962 | pmc = 321451 | doi = 10.1128/MCB.24.3.1168-1173.2004 }}
* {{cite journal | vauthors = Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD | title = More than blood, a novel gene required for mammalian postimplantation development | journal = Molecular and Cellular Biology | volume = 24 | issue = 3 | pages = 1168–73 | date = February 2004 | pmid = 14729962 | pmc = 321451 | doi = 10.1128/MCB.24.3.1168-1173.2004 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = April 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = April 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N }}
{{refend}}
{{refend}}


Revision as of 00:11, 20 March 2020

NCAPG2
Identifiers
AliasesNCAPG2, CAP-G2, CAPG2, LUZP5, MTB, hCAP-G2, non-SMC condensin II complex subunit G2, 3KS
External IDsOMIM: 608532; MGI: 1923294; HomoloGene: 9820; GeneCards: NCAPG2; OMA:NCAPG2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

54892

76044

Ensembl

ENSG00000146918

ENSMUSG00000042029

UniProt

Q86XI2

Q6DFV1

RefSeq (mRNA)

NM_001281932
NM_001281933
NM_017760

NM_133762

RefSeq (protein)

NP_001268861
NP_001268862
NP_060230

NP_598523

Location (UCSC)Chr 7: 158.63 – 158.7 MbChr 12: 116.37 – 116.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Condensin-2 complex subunit G2 (CAP-G2) also known as chromosome-associated protein G2 (CAP-G2) or leucine zipper protein 5 (LUZP5) is a protein that in humans is encoded by the NCAPG2 gene.[5][6] CAP-G2 is a subunit of condensin II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis[7]

Clinical importance

Mutations in this gene in humans have been associated with severe neurodevelopmental defects, failure to thrive, ocular abnormalities, and defects in urogenital and limb morphogenesis.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146918 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042029 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T (October 2003). "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells". Cell. 115 (1): 109–21. doi:10.1016/S0092-8674(03)00724-4. PMID 14532007.
  6. ^ "Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2".
  7. ^ Kim JH, Shim J, Ji MJ, Jung Y, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee C, Lee BI, Kim KT (August 2014). "The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores". Nature Communications. 5: 4588. Bibcode:2014NatCo...5.4588K. doi:10.1038/ncomms5588. PMID 25109385.
  8. ^ Khan TN, Khan K, Sadeghpour A, Reynolds H, Perilla Y, McDonald MT, Gallentine WB, Baig SM, Davis EE, Katsanis N, et al. (Task Force for Neonatal Genomics) (January 2019). "Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies". American Journal of Human Genetics. 104 (1): 94–111. doi:10.1016/j.ajhg.2018.11.017. PMC 6323578. PMID 30609410.

Further reading

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