Antibody-oligonucleotide conjugate: Difference between revisions
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'''Antibody-oligonucleotide conjugates''' or '''AOCs''' belong to a class of chimeric molecules combining in their structure two important families of biomolecules: monoclonal [[antibodies]] and [[oligonucleotides]].<ref name=":0">{{cite journal |last1=Dovgan |first1=Igor |last2=Koniev |first2=Oleksandr |last3=Kolodych |first3=Sergii |last4=Wagner |first4=Alain |title=Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents |journal=Bioconjugate Chemistry |volume=30 |issue=10 |pages=2483–2501 |year=2019 |doi=10.1021/acs.bioconjchem.9b00306 |pmid=31339691 |issn=1043-1802}}</ref> |
'''Antibody-oligonucleotide conjugates''' or '''AOCs''' belong to a class of chimeric molecules combining in their structure two important families of biomolecules: monoclonal [[antibodies]] and [[oligonucleotides]].<ref name=":0">{{cite journal |last1=Dovgan |first1=Igor |last2=Koniev |first2=Oleksandr |last3=Kolodych |first3=Sergii |last4=Wagner |first4=Alain |title=Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents |journal=Bioconjugate Chemistry |volume=30 |issue=10 |pages=2483–2501 |year=2019 |doi=10.1021/acs.bioconjchem.9b00306 |pmid=31339691 |issn=1043-1802}}</ref> |
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Combination of exceptional targeting capabilities of [[Monoclonal antibody|monoclonal antibodies]] with numerous functional modalities of [[oligonucleotide|oligonucleotides]] has been fruitful for a variety of applications with AOC including imaging, detection and targeted therapeutics.<ref name=":0" /><ref name="Levin pp. 86–88">{{cite journal | last=Levin | first=Arthur A. | title=Targeting Therapeutic Oligonucleotides | journal=New England Journal of Medicine | publisher=Massachusetts Medical Society | volume=376 | issue=1 | year=2017 | issn=0028-4793 | doi=10.1056/nejmcibr1613559 | pmid=28052219 | pages=86–88}}</ref><ref name="Winkler 2013 pp. 791–809">{{cite journal | last=Winkler | first=Johannes | title=Oligonucleotide conjugates for therapeutic applications | journal=Therapeutic Delivery | publisher=Future Science Ltd | volume=4 | issue=7 | year=2013 | issn=2041-5990 | doi=10.4155/tde.13.47 | pages=791–809}}</ref> |
Combination of exceptional targeting capabilities of [[Monoclonal antibody|monoclonal antibodies]] with numerous functional modalities of [[oligonucleotide|oligonucleotides]] has been fruitful for a variety of applications with AOC including imaging, detection and targeted therapeutics.<ref name=":0" /><ref name="Levin pp. 86–88">{{cite journal | last=Levin | first=Arthur A. | title=Targeting Therapeutic Oligonucleotides | journal=New England Journal of Medicine | publisher=Massachusetts Medical Society | volume=376 | issue=1 | year=2017 | issn=0028-4793 | doi=10.1056/nejmcibr1613559 | pmid=28052219 | pages=86–88}}</ref><ref name="Winkler 2013 pp. 791–809">{{cite journal | last=Winkler | first=Johannes | title=Oligonucleotide conjugates for therapeutic applications | journal=Therapeutic Delivery | publisher=Future Science Ltd | volume=4 | issue=7 | year=2013 | issn=2041-5990 | doi=10.4155/tde.13.47 | pages=791–809| doi-access=free }}</ref> |
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== See also == |
== See also == |
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Revision as of 14:55, 14 April 2020
Antibody-oligonucleotide conjugates or AOCs belong to a class of chimeric molecules combining in their structure two important families of biomolecules: monoclonal antibodies and oligonucleotides.[1]
Combination of exceptional targeting capabilities of monoclonal antibodies with numerous functional modalities of oligonucleotides has been fruitful for a variety of applications with AOC including imaging, detection and targeted therapeutics.[1][2][3]
See also
References
- ^ a b Dovgan, Igor; Koniev, Oleksandr; Kolodych, Sergii; Wagner, Alain (2019). "Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents". Bioconjugate Chemistry. 30 (10): 2483–2501. doi:10.1021/acs.bioconjchem.9b00306. ISSN 1043-1802. PMID 31339691.
- ^ Levin, Arthur A. (2017). "Targeting Therapeutic Oligonucleotides". New England Journal of Medicine. 376 (1). Massachusetts Medical Society: 86–88. doi:10.1056/nejmcibr1613559. ISSN 0028-4793. PMID 28052219.
- ^ Winkler, Johannes (2013). "Oligonucleotide conjugates for therapeutic applications". Therapeutic Delivery. 4 (7). Future Science Ltd: 791–809. doi:10.4155/tde.13.47. ISSN 2041-5990.