SIN3B: Difference between revisions

SIN3B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E91, 1PD7, 2CR7, 2CZY, 2F05
Identifiers
Aliases	SIN3B, Paired amphipathic helix protein Sin3b, SIN3 transcription regulator family member B
External IDs	OMIM: 607777; MGI: 107158; HomoloGene: 81810; GeneCards: SIN3B; OMA:SIN3B - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	16,880,353 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	73,484,829 bp
RNA expression pattern
	Top expressed in
	body of uterus; ; right uterine tube; ; right ovary; ; left ovary; ; canal of the cervix; ; right lung; ; gastric mucosa; ; left uterine tube; ; left testis; ; sural nerve;
	Top expressed in
	Gonadal ridge; ; Paneth cell; ; internal carotid artery; ; external carotid artery; ; fossa; ; renal corpuscle; ; epithelium of lens; ; condyle; ; endocardial cushion; ; medullary collecting duct;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity; histone deacetylase activity; chromatin binding; protein binding;
Cellular component	cytoplasm; X chromosome; Y chromosome; autosome; Sin3 complex; nucleoplasm; XY body; nucleus; chromatin;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of transcription, DNA-templated; histone deacetylation; regulation of lipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	23309
	20467
	ENSG00000127511
	ENSMUSG00000031622
	O75182
	Q62141
	NM_001297595; NM_001297597; NM_015260
	NM_001113248; NM_009188
	NP_001284524; NP_001284526; NP_056075
	NP_001106719; NP_033214
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 13:11, 15 April 2020

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.^[5]^[6]

Interactions

SIN3B has been shown to interact with HDAC1,^[7]^[8] Zinc finger and BTB domain-containing protein 16,^[9] SUDS3^[10] and IKZF1.^[8]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127511 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031622 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ "Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)".
^ Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development. 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591.
^ ^a ^b Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820.
^ David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120.
^ Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (Apr 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.
^ Koipally J, Georgopoulos K (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.

External links

SIN3B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127511 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031622 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[entrez-6] "Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)".

[pmid10444591-7] Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development. 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591.

[pmid10357820-8] Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820.

[pmid9627120-9] David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120.

[pmid11909966-10] Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (Apr 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.

[pmid12015313-11] Koipally J, Georgopoulos K (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.

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@@ Line 1: / Line 1: @@
 {{Infobox_gene}}
-'''Paired amphipathic helix protein Sin3b''' is a [[protein]] that in humans is encoded by the ''SIN3B'' [[gene]].<ref name="pmid9734811">{{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 3 | pages = 169–76 | date = Jun 1998 | pmid = 9734811 | pmc =  | doi = 10.1093/dnares/5.3.169 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23309| accessdate = }}</ref>
+'''Paired amphipathic helix protein Sin3b''' is a [[protein]] that in humans is encoded by the ''SIN3B'' [[gene]].<ref name="pmid9734811">{{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 3 | pages = 169–76 | date = Jun 1998 | pmid = 9734811 | pmc =  | doi = 10.1093/dnares/5.3.169 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23309| accessdate = }}</ref>
 == Interactions ==
-SIN3B has been shown to [[Protein-protein interaction|interact]] with [[HDAC1]],<ref name=pmid10444591>{{cite journal | vauthors = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | journal = Genes & Development | volume = 13 | issue = 15 | pages = 1924–35 | date = Aug 1999 | pmid = 10444591 | pmc = 316920 | doi = 10.1101/gad.13.15.1924 }}</ref><ref name=pmid10357820>{{cite journal | vauthors = Koipally J, Renold A, Kim J, Georgopoulos K | title = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | journal = The EMBO Journal | volume = 18 | issue = 11 | pages = 3090–100 | date = Jun 1999 | pmid = 10357820 | pmc = 1171390 | doi = 10.1093/emboj/18.11.3090 }}</ref> [[Zinc finger and BTB domain-containing protein 16]],<ref name=pmid9627120>{{cite journal | vauthors = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–56 | date = May 1998 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043 }}</ref> [[SUDS3]]<ref name=pmid11909966>{{cite journal | vauthors = Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA | title = Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2743–50 | date = Apr 2002 | pmid = 11909966 | pmc = 133736 | doi = 10.1128/MCB.22.8.2743-2750.2002 }}</ref> and [[IKZF1]].<ref name=pmid10357820/><ref name=pmid12015313>{{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–705 | date = Aug 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 }}</ref>
+SIN3B has been shown to [[Protein-protein interaction|interact]] with [[HDAC1]],<ref name=pmid10444591>{{cite journal | vauthors = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | journal = Genes & Development | volume = 13 | issue = 15 | pages = 1924–35 | date = Aug 1999 | pmid = 10444591 | pmc = 316920 | doi = 10.1101/gad.13.15.1924 }}</ref><ref name=pmid10357820>{{cite journal | vauthors = Koipally J, Renold A, Kim J, Georgopoulos K | title = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | journal = The EMBO Journal | volume = 18 | issue = 11 | pages = 3090–100 | date = Jun 1999 | pmid = 10357820 | pmc = 1171390 | doi = 10.1093/emboj/18.11.3090 }}</ref> [[Zinc finger and BTB domain-containing protein 16]],<ref name=pmid9627120>{{cite journal | vauthors = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–56 | date = May 1998 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043 | doi-access = free }}</ref> [[SUDS3]]<ref name=pmid11909966>{{cite journal | vauthors = Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA | title = Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2743–50 | date = Apr 2002 | pmid = 11909966 | pmc = 133736 | doi = 10.1128/MCB.22.8.2743-2750.2002 }}</ref> and [[IKZF1]].<ref name=pmid10357820/><ref name=pmid12015313>{{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–705 | date = Aug 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 | doi-access = free }}</ref>
 == See also ==
@@ Line 15: / Line 15: @@
 {{refbegin | 2}}
 * {{cite journal | vauthors = Ayer DE, Lawrence QA, Eisenman RN | title = Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3 | journal = Cell | volume = 80 | issue = 5 | pages = 767–76 | date = Mar 1995 | pmid = 7889570 | doi = 10.1016/0092-8674(95)90355-0 }}
-* {{cite journal | vauthors = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–56 | date = May 1998 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043 }}
+* {{cite journal | vauthors = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–56 | date = May 1998 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043 | doi-access = free }}
 * {{cite journal | vauthors = Koipally J, Renold A, Kim J, Georgopoulos K | title = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | journal = The EMBO Journal | volume = 18 | issue = 11 | pages = 3090–100 | date = Jun 1999 | pmid = 10357820 | pmc = 1171390 | doi = 10.1093/emboj/18.11.3090 }}
 * {{cite journal | vauthors = Naruse Y, Aoki T, Kojima T, Mori N | title = Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 24 | pages = 13691–6 | date = Nov 1999 | pmid = 10570134 | pmc = 24126 | doi = 10.1073/pnas.96.24.13691 }}
@@ Line 22: / Line 22: @@
 * {{cite journal | vauthors = Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA | title = Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2743–50 | date = Apr 2002 | pmid = 11909966 | pmc = 133736 | doi = 10.1128/MCB.22.8.2743-2750.2002 }}
 * {{cite journal | vauthors = Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD | title = E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex | journal = Genes & Development | volume = 16 | issue = 8 | pages = 933–47 | date = Apr 2002 | pmid = 11959842 | pmc = 152357 | doi = 10.1101/gad.969202 }}
-* {{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–705 | date = Aug 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 }}
+* {{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–705 | date = Aug 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 | doi-access = free }}
 * {{cite journal | vauthors = Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA | title = An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B | journal = The Biochemical Journal | volume = 369 | issue = Pt 3 | pages = 651–7 | date = Feb 2003 | pmid = 12398767 | pmc = 1223118 | doi = 10.1042/BJ20020854 }}
-* {{cite journal | vauthors = Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A | title = The histone deacetylase 9 gene encodes multiple protein isoforms | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16059–72 | date = May 2003 | pmid = 12590135 | doi = 10.1074/jbc.M212935200 }}
+* {{cite journal | vauthors = Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A | title = The histone deacetylase 9 gene encodes multiple protein isoforms | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16059–72 | date = May 2003 | pmid = 12590135 | doi = 10.1074/jbc.M212935200 | doi-access = free }}
 * {{cite journal | vauthors = Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W | title = Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 | journal = Genes & Development | volume = 17 | issue = 7 | pages = 896–911 | date = Apr 2003 | pmid = 12670868 | pmc = 196026 | doi = 10.1101/gad.252103 }}
-* {{cite journal | vauthors = Dugast-Darzacq C, Pirity M, Blanck JK, Scherl A, Schreiber-Agus N | title = Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential | journal = Oncogene | volume = 23 | issue = 55 | pages = 8887–99 | date = Nov 2004 | pmid = 15467743 | doi = 10.1038/sj.onc.1208107 }}
+* {{cite journal | vauthors = Dugast-Darzacq C, Pirity M, Blanck JK, Scherl A, Schreiber-Agus N | title = Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential | journal = Oncogene | volume = 23 | issue = 55 | pages = 8887–99 | date = Nov 2004 | pmid = 15467743 | doi = 10.1038/sj.onc.1208107 | doi-access = free }}
 * {{cite journal | vauthors = Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S | title = Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex | journal = Molecular and Cellular Biology | volume = 25 | issue = 19 | pages = 8415–29 | date = Oct 2005 | pmid = 16166625 | pmc = 1265755 | doi = 10.1128/MCB.25.19.8415-8429.2005 }}
 * {{cite journal | vauthors = Xu Y, Sengupta PK, Seto E, Smith BD | title = Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression | journal = The Journal of Biological Chemistry | volume = 281 | issue = 14 | pages = 9260–70 | date = Apr 2006 | pmid = 16464847 | pmc = 1434794 | doi = 10.1074/jbc.M511724200 }}

v t e Transcription coregulators
Coactivators	ARA (54, 55, 70) BCAS3 CARM1 p300-CBP (EP300, CREBBP) CRTC (1, 2, 3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1, 2) PPARGC (1A, 1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140)
Corepressors	CTBP (1, 2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 RCOR1 Rb SIN3A SIN3B Tripartite motif family TRIM (24, 28, 33) NCOR1 NCOR2 (SMRT)
ATP-dependent remodeling factors	Chromatin Structure Remodeling (RSC) Complex SWI/SNF

Revision as of 13:11, 15 April 2020

Interactions

See also

References

Further reading

External links