TRA (gene): Difference between revisions

TRA
Identifiers
Aliases	TRA, IMD7, TCRA, TRA@, TRAC, T-cell receptor alpha locus, TCRD, T cell receptor alpha locus
External IDs	GeneCards: TRA; OMA:TRA - orthologs
Orthologs
	6955
	n/a
	n/a
	n/a
	P0DSE1
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
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Revision as of 14:32, 18 April 2020

T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or TRA@.^[2]^[3]^[4] It contributes the alpha chain to the larger TCR protein (T-cell receptor).

References

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Erikson J, Williams DL, Finan J, Nowell PC, Croce CM (Sep 1985). "Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias". Science. 229 (4715): 784–6. doi:10.1126/science.3875152. PMID 3875152.
^ Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN (Oct 1985). "The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia". EMBO J. 4 (6): 1461–5. PMC 554368. PMID 3875483.
^ "Entrez Gene: TRA@ T cell receptor alpha locus".

Kenwrick S; Levinson B; Taylor S; et al. (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID 1303175. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Suzuki CK; Bonifacino JS; Lin AY; et al. (1991). "Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP". J. Cell Biol. 114 (2): 189–205. doi:10.1083/jcb.114.2.189. PMC 2289081. PMID 1649196. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Travis A, Amsterdam A, Belanger C, Grosschedl R (1991). "LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]". Genes Dev. 5 (5): 880–94. doi:10.1101/gad.5.5.880. PMID 1827423.
Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299–305. doi:10.1002/eji.1830200211. PMID 2138083.
Dyer MJ (1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms". Blood. 74 (3): 1073–83. PMID 2546634.
Chilson OP, Kelly-Chilson AE (1989). "Mitogenic lectins bind to the antigen receptor on human lymphocytes". Eur. J. Immunol. 19 (2): 389–96. doi:10.1002/eji.1830190225. PMID 2703017.
Yanagi Y; Chan A; Chin B; et al. (1985). "Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line". Proc. Natl. Acad. Sci. U.S.A. 82 (10): 3430–4. doi:10.1073/pnas.82.10.3430. PMC 397789. PMID 3873654. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Sim GK; Yagüe J; Nelson J; et al. (1985). "Primary structure of human T-cell receptor alpha-chain". Nature. 312 (5996): 771–5. doi:10.1038/312771a0. PMID 6440030. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Kearse KP, Roberts JL, Singer A (1995). "TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes". Immunity. 2 (4): 391–9. doi:10.1016/1074-7613(95)90147-7. PMID 7719941.
Manolios N, Kemp O, Li ZG (1994). "The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains". Eur. J. Immunol. 24 (1): 84–92. doi:10.1002/eji.1830240114. PMID 8020575.
Bagga R, Emerson BM (1997). "An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro". Genes Dev. 11 (5): 629–39. doi:10.1101/gad.11.5.629. PMID 9119227.
San José E, Sahuquillo AG, Bragado R, Alarcón B (1998). "Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model". Eur. J. Immunol. 28 (1): 12–21. doi:10.1002/(SICI)1521-4141(199801)28:01<12::AID-IMMU12>3.0.CO;2-9. PMID 9485181.
Ding YH; Smith KJ; Garboczi DN; et al. (1998). "Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids". Immunity. 8 (4): 403–11. doi:10.1016/S1074-7613(00)80546-4. PMID 9586631. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Kirchgessner H; Dietrich J; Scherer J; et al. (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Shelton JG; Gülland S; Nicolson K; et al. (2001). "Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits". Mol. Immunol. 38 (4): 259–65. doi:10.1016/S0161-5890(01)00062-1. PMID 11566319. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Pietra G; Romagnani C; Falco M; et al. (2002). "The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition". Eur. J. Immunol. 31 (12): 3687–93. doi:10.1002/1521-4141(200112)31:12<3687::AID-IMMU3687>3.0.CO;2-C. PMID 11745389. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Hennecke J, Wiley DC (2002). "Structure of a Complex of the Human α/β T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401): Insight into TCR Cross-Restriction and Alloreactivity". J. Exp. Med. 195 (5): 571–81. doi:10.1084/jem.20011194. PMC 2193773. PMID 11877480.
García P; Llano M; de Heredia AB; et al. (2002). "Human T cell receptor-mediated recognition of HLA-E". Eur. J. Immunol. 32 (4): 936–44. doi:10.1002/1521-4141(200204)32:4<936::AID-IMMU936>3.0.CO;2-M. PMID 11920559. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

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[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3875152-2] Erikson J, Williams DL, Finan J, Nowell PC, Croce CM (Sep 1985). "Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias". Science. 229 (4715): 784–6. doi:10.1126/science.3875152. PMID 3875152.

[pmid3875483-3] Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN (Oct 1985). "The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia". EMBO J. 4 (6): 1461–5. PMC 554368. PMID 3875483.

[entrez-4] "Entrez Gene: TRA@ T cell receptor alpha locus".

[1]

[2]

[3]

[4]

@@ Line 12: / Line 12: @@
 *{{cite journal  | author=Kenwrick S |title=Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene |journal=Hum. Mol. Genet. |volume=1 |issue= 3 |pages= 179–86 |year= 1993 |pmid= 1303175 |doi=10.1093/hmg/1.3.179  |name-list-format=vanc| author2=Levinson B  | author3=Taylor S  | display-authors=3  | last4=Shapiro  | first4=Amy  | last5=Gitschier  | first5=Jane  }}
 *{{cite journal  | author=Suzuki CK |title=Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP |journal=J. Cell Biol. |volume=114 |issue= 2 |pages= 189–205 |year= 1991 |pmid= 1649196 |doi=10.1083/jcb.114.2.189  | pmc=2289081  |name-list-format=vanc| author2=Bonifacino JS  | author3=Lin AY  | display-authors=3  | last4=Davis  | first4=MM  | last5=Klausner  | first5=RD  }}
-*{{cite journal  |vauthors=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880–94 |year= 1991 |pmid= 1827423 |doi=10.1101/gad.5.5.880  }}
+*{{cite journal  |vauthors=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880–94 |year= 1991 |pmid= 1827423 |doi=10.1101/gad.5.5.880  |doi-access=free }}
 *{{cite journal  |vauthors=Koning F, Maloy WL, Coligan JE |title=The implications of subunit interactions for the structure of the T cell receptor-CD3 complex |journal=Eur. J. Immunol. |volume=20 |issue= 2 |pages= 299–305 |year= 1990 |pmid= 2138083 |doi=10.1002/eji.1830200211  }}
 *{{cite journal  | author=Dyer MJ |title=T-cell receptor delta/alpha rearrangements in lymphoid neoplasms |journal=Blood |volume=74 |issue= 3 |pages= 1073–83 |year= 1989 |pmid= 2546634 |doi=  }}
@@ Line 20: / Line 20: @@
 *{{cite journal  |vauthors=Kearse KP, Roberts JL, Singer A |title=TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes |journal=Immunity |volume=2 |issue= 4 |pages= 391–9 |year= 1995 |pmid= 7719941 |doi= 10.1016/1074-7613(95)90147-7 }}
 *{{cite journal  |vauthors=Manolios N, Kemp O, Li ZG |title=The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains |journal=Eur. J. Immunol. |volume=24 |issue= 1 |pages= 84–92 |year= 1994 |pmid= 8020575 |doi=10.1002/eji.1830240114  }}
-*{{cite journal  |vauthors=Bagga R, Emerson BM |title=An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro |journal=Genes Dev. |volume=11 |issue= 5 |pages= 629–39 |year= 1997 |pmid= 9119227 |doi=10.1101/gad.11.5.629  }}
+*{{cite journal  |vauthors=Bagga R, Emerson BM |title=An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro |journal=Genes Dev. |volume=11 |issue= 5 |pages= 629–39 |year= 1997 |pmid= 9119227 |doi=10.1101/gad.11.5.629  |doi-access=free }}
 *{{cite journal  |vauthors=San José E, Sahuquillo AG, Bragado R, Alarcón B |title=Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model |journal=Eur. J. Immunol. |volume=28 |issue= 1 |pages= 12–21 |year= 1998 |pmid= 9485181 |doi=10.1002/(SICI)1521-4141(199801)28:01<12::AID-IMMU12>3.0.CO;2-9  }}
 *{{cite journal  | author=Ding YH |title=Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids |journal=Immunity |volume=8 |issue= 4 |pages= 403–11 |year= 1998 |pmid= 9586631 |doi=10.1016/S1074-7613(00)80546-4  |name-list-format=vanc| author2=Smith KJ  | author3=Garboczi DN  | display-authors=3  | last4=Utz  | first4=Ursula  | last5=Biddison  | first5=William E.  | last6=Wiley  | first6=Don C.  }}

Revision as of 14:32, 18 April 2020

References

Further reading